How should we investigate CUO (C-Reactive Protein elevation of Unknown Origin)? A case-based discussion of infective endocarditis in an octogenarian

Ford, Joanna; Seymour, D. G.; Newnham, D M

doi:10.1007/bf03325256

Cited by 1 publication

(1 citation statement)

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“…The typical manifesta-tions of IE are not always clearly expressed, and the fi rst clinical signs may be nonspecifi c and may be distinct in variety. It is diffi cult to establish the diagnosis of prosthetic valve endocarditis in elderly patients, in the absence of positive data from bacteriological blood tests, and the presence of false positive or negative echocardiographic results (19)(20)(21). The frequency of detection of primary IE during surgery is still between 21 % and 30 %, reaching 38.2% at postmortem examination (22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Changing profile of infective endocarditis during a 20-year observation period

Tazina¹,

Fedorova²,

Semenenko³

et al. 2023

BLL

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BACKGROUND: Infective endocarditis (IE) is most often caused by bacteria. OBJECTIVES: The aim of this work is the research of the dynamics of the clinical laboratory and instrumental methods of the diagnostics during the period of two decades. METHODS: The data of 241 patients with infective endocarditis (IE) who were treated at the State Clinical Hospital named after Botkin S.P. was included in the research. 121 patients were observed from 2011 till 2020 (the fi rst group) and 120 patients -from 1997 to 2004 (the second test group). These data included age and social structure of pathology, peculiarities of clinical picture, laboratory, and instrumental methods of research, as well as the outcome of the disease. We studied the concentrations of procalcitonin and presepsin in patients hospitalized after 2011. We observed pathomorphism of the modern IE. RESULTS: To discover the bacteriological origin of the disease, we found the diagnostic evaluation of infl ammation, procalcitonin, and presepsin activities, using C-reactive protein, important. We observed decrease in the number of general and hospital deaths. CONCLUSIONS: The knowledge of the IE peculiarities during the IE progression is essential for timely diagnosis and more accurate pathology prediction (Fig. 5, Ref. 38).

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