How should prostate specific antigen be interpreted?

Atan, Ali; Güzel, Özer

doi:10.5152/tud.2013.038

Cited by 17 publications

(15 citation statements)

References 51 publications

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“…The normal level of tPSA level is <4ng/mL, FPSA level is <0.01ng/mL whereas percentage PSA is >25% [8]. In case of carcinoma there is up to 10 folds increase in tPSA level [8]. In our study the mean tPSA level was 100.08 ng/mL (range 4.87 to 1564 ng/mL) with standard deviation of 287.89.…”

Section: Discussionsupporting

confidence: 38%

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Perineural Invasion in Prostatic Carcinoma as Detected by S100 and its Implication in Prognosis

Sneha¹

2019

SJPM

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Background and objectives: Carcinoma prostate is becoming an increasingly significant international health problem. Perineural tumour growth is associated with adverse prognostic features and a poor outcome; hence is a necessary component in histopathological reporting of malignancy. For accurate detection of perineural cancer spread, immunohistochemistry (IHC) with S100 was performed along with haematoxylin and eosin (H&E) stain. This study attempts to correlate the clinic-pathological prognostic factors with PNI, in a regional scenario. Methods: A retrospective study was conducted at a tertiary care hospital over a period of one year. Specimens were trurcut biopsy, TURP chips and prostatectomy specimen, sent in 10% formalin. Paraffin embedded blocks was stained with H&E and representative sections with S100. Relationship of tumor with nerve was established and graded accordingly as: Category 0: nerves without immediate tumor-cell-contact. All nerves being fully surrounded by tumor (classical perineural invasion) were categorized group 3. Two further categories discriminated between nerves that were touched either by carcinoma cells below 50% of the circumference (category 1) or above 50% as category 2. Results: Out of 30 cases of prostatic adenocarcinoma, majority of specimens were needle biopsies (47%). The age of presentation were 55-84years with mean age being 68.93 years. Pretreatment and posttreatment PSA levels were assessed. Most common presentation was bladder outlet obstruction (57%) and treatment given was radical Prostatectomy (44%). Perineural invasion (PNI) was seen in 66.7% of cases and correlated positively with Gleason's score, pT categories, %PSA. Perineural spread noted in 73.3% cases and negatively correlated with Grade group.

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Section: Discussionsupporting

confidence: 38%

“…The most common affected males in our study belonged to the age group of 55-84yrs. The normal level of tPSA level is <4ng/mL, FPSA level is <0.01ng/mL whereas percentage PSA is >25% [8]. In case of carcinoma there is up to 10 folds increase in tPSA level [8].…”

Section: Discussionmentioning

confidence: 89%

Perineural Invasion in Prostatic Carcinoma as Detected by S100 and its Implication in Prognosis

Sneha¹

2019

SJPM

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“…We analyzed the relationships between polymorphisms of the EGF and EGFR genes and BPH. The BPH patients were dichotomized according to prostate volume, IPSS score, and PSA level [19,20]. The genotype and allele distributions of the tested SNPs are shown in Tables 3 and 4 for each group.…”

Section: Resultsmentioning

confidence: 99%

Association Study of Polymorphisms of Epidermal Growth Factor and Epidermal Growth Factor Receptor With Benign Prostatic Hyperplasia in a Korean Population

et al. 2016

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PurposeRecent studies have suggested that specific single-nucleotide polymorphisms (SNPs) contribute to the clinical features of benign prostatic hyperplasia (BPH). In this study, we investigated the relationships of genetic polymorphisms of the epidermal growth factor (EGF) gene and the epidermal growth factor receptor (EGFR) gene with BPH.MethodsA total of 218 patients with BPH were enrolled in this study. We evaluated the relationship between eight SNPs in the EGF and EGFR genes and prostate volume, prostate-specific antigen (PSA), and International Prostate Symptom Score of BPH patients. Each SNP was genotyped by direct sequencing. Statistical analysis applying codominant, dominant, recessive, and log-additive models was performed via logistic regression.ResultsThe rs11568943 and rs11569017 SNPs in the EGF gene showed significant associations with prostate volume (rs11568943: P=0.038 in the log-additive model, P=0.024 in the allele distribution; rs11569017, P=0.031 in the dominant model, P=0.028 in the log-additive model, P=0.020 in the allele distribution). Additionally, the rs3756261, rs11568943, and rs11569017 SNPs of the EGF gene and the rs2293347 SNP of the EGFR gene were associated with PSA levels (P<0.05 in each model, respectively).ConclusionsThese results suggest that the EGF gene may affect prostate volume. In addition, the EGF and EGFR genes may be associated with PSA levels in patients with BPH.

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“…First, there are multiple sources of TEa for total PSA. Second, total PSA has more than one intended use – it may be used for screening subjects for prostate cancer or for monitoring patients ( 11 ). Lastly, total PSA has generally accepted medical decision concentrations ( 11 , 12 ).…”

Section: Methodsmentioning

confidence: 99%

Using Sigma metrics to establish analytical product performance requirements and optimize analytical performance of an in vitro diagnostic assay using a theoretical total PSA assay as an example

Petrides

Schneider

2018

Biochemia Medica

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IntroductionEstablishing analytical performance requirements for in vitro diagnostic (IVD) assays is a challenging process. Manufacturers try to optimize analytical performance by choosing amongst many combinations of different product performance characteristics. Sigma metrics and method decision charts can be helpful aids in choosing appropriate analytical performance requirements. The objective of this research was to demonstrate the use of Sigma metrics and method decision charts to help establish analytical performance requirements and to optimize analytical performance at medical decision concentrations for an IVD assay.Materials and methodsA range of possible Sigma metrics were determined using three sources for total allowable error (TEa) and hypothetical total PSA assay results. Method decision charts were created for each TEa source and used to identify the maximum precision and bias that the assay could have to maintain sigma level performance of at least 3.ResultsTo achieve a sigma performance level of at least 3 for a hypothetical total PSA assay, the maximum allowable coefficient of variation ranged from 5.0% to 11.2% depending on the TEa source. To achieve a sigma performance level of at least 6, the maximum allowable coefficient of variation ranged from 2.5% to 5.6% depending on the TEa source.ConclusionsUsing Sigma metrics and method decision charts when establishing analytical performance requirements can help manufacturers choose product requirements that will optimize IVD assay product performance.

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How should prostate specific antigen be interpreted?

Cited by 17 publications

References 51 publications

Perineural Invasion in Prostatic Carcinoma as Detected by S100 and its Implication in Prognosis

Perineural Invasion in Prostatic Carcinoma as Detected by S100 and its Implication in Prognosis

Association Study of Polymorphisms of Epidermal Growth Factor and Epidermal Growth Factor Receptor With Benign Prostatic Hyperplasia in a Korean Population

Using Sigma metrics to establish analytical product performance requirements and optimize analytical performance of an in vitro diagnostic assay using a theoretical total PSA assay as an example

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