How Should Lumped Constant Be Estimated for Hepatic <sup>18</sup>F-FDG Glucose in Humans?

Keiding, Susanne

doi:10.2967/jnumed.115.161422

Cited by 2 publications

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“…Among them, 18 F-FDG PET/CT is a non-invasive method to study biochemical and metabolic changes in tumor tissues, which provides useful functional information for identifying surviving tumor tissues [11]. 18 F-FDG metabolic imaging expresses the metabolic level of glucose molecules in the cell [12][13][14]. Tumor cells have increased nucleus division, active cell proliferation, and increased glucose metabolism, which is manifested by increased FDG metabolism and an increased SUV at the lesion.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of 18F-FDG PET/CT imaging in 32 cases of gastrointestinal stromal tumors

et al. 2022

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Objectives To explore the clinical significance of 18F-FDG metabolic imaging in the diagnosis and biological risk assessment of gastrointestinal stromal tumors (GIST). Methods This study is a clinical retrospective study. The research subjects were patients with GIST who were admitted to our hospital from January 2014 to December 2019 and underwent 18F-FDG metabolic imaging, and the relationship between biological risk and FDG metabolism was analyzed retrospectively. Results A total of 32 patients with GIST were included in this study, of which 17 patients had very low and low-risk lesions, and the FDG metabolism level did not increase; five patients had moderate-risk gastric lesions, and the FDG metabolism level was abnormally increased; 10 patients had high-risk lesions, and except for one patient with multiple lesions, the FDG metabolism level of these patients was increased. Conclusions The level of glucose metabolism is abnormally increased in tumor cells with vigorous mitosis and has higher biological risk. The 18F-FDG metabolism level can determine the biological risk of GIST and whether high-risk lesions involve other tissues and organs, as it more comprehensively reflects the distribution of lesions, the activity of tumor cells and the stage of the disease.

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Section: Discussionmentioning

confidence: 99%

Clinical significance of 18F-FDG PET/CT imaging in 32 cases of gastrointestinal stromal tumors

et al. 2022

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Hepatic Positron Emission Tomography: Applications in Metabolism, Haemodynamics and Cancer

et al. 2022

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Evaluating in vivo the metabolic rates of the human liver has been a challenge due to its unique perfusion system. Positron emission tomography (PET) represents the current gold standard for assessing non-invasively tissue metabolic rates in vivo. Here, we review the existing literature on the assessment of hepatic metabolism, haemodynamics and cancer with PET. The tracer mainly used in metabolic studies has been [18F]2-fluoro-2-deoxy-D-glucose (18F-FDG). Its application not only enables the evaluation of hepatic glucose uptake in a variety of metabolic conditions and interventions, but based on the kinetics of 18F-FDG, endogenous glucose production can also be assessed. 14(R,S)-[18F]fluoro-6-thia-Heptadecanoic acid (18F-FTHA), 11C-Palmitate and 11C-Acetate have also been applied for the assessment of hepatic fatty acid uptake rates (18F-FTHA and 11C-Palmitate) and blood flow and oxidation (11C-Acetate). Oxygen-15 labelled water (15O-H2O) has been used for the quantification of hepatic perfusion. 18F-FDG is also the most common tracer used for hepatic cancer diagnostics, whereas 11C-Acetate has also shown some promising applications in imaging liver malignancies. The modelling approaches used to analyse PET data and also the challenges in utilizing PET in the assessment of hepatic metabolism are presented.

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How Should Lumped Constant Be Estimated for Hepatic ¹⁸F-FDG Glucose in Humans?

Cited by 2 publications

References 13 publications

Clinical significance of 18F-FDG PET/CT imaging in 32 cases of gastrointestinal stromal tumors

Clinical significance of 18F-FDG PET/CT imaging in 32 cases of gastrointestinal stromal tumors

Hepatic Positron Emission Tomography: Applications in Metabolism, Haemodynamics and Cancer

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How Should Lumped Constant Be Estimated for Hepatic 18F-FDG Glucose in Humans?

Cited by 2 publications

References 13 publications

Clinical significance of 18F-FDG PET/CT imaging in 32 cases of gastrointestinal stromal tumors

Clinical significance of 18F-FDG PET/CT imaging in 32 cases of gastrointestinal stromal tumors

Hepatic Positron Emission Tomography: Applications in Metabolism, Haemodynamics and Cancer

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How Should Lumped Constant Be Estimated for Hepatic ¹⁸F-FDG Glucose in Humans?