How self-assembly of amphiphilic molecules can generate complexity in the nanoscale

Calandra, Pietro; Caschera, Daniela; Liveri, Vincenzo Turco; Lombardo, Domenico

doi:10.1016/j.colsurfa.2015.07.058

Cited by 68 publications

(42 citation statements)

References 123 publications

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“…Recent developments in nanoscience stimulated the combination of the simple approaches of liposome technology with the advanced concept of supramolecular self-assembly for the development of more complex, hierarchical nanostructures [108,112,113]. The introduction of multi-functional, multi-component formulations that perform (within the same liposome theranostic platform) different functions, such as the delivery of combinations of therapeutic drugs, site-specific targeting/imaging capabilities, and/or stimuli responsive assembly/disassembly processes to control drug release, allows for the development of a large variety of theranostic systems capable of performing a defined set of bio-medical tasks (Figure 11).…”

Section: Future Perspectives: the Theranostic Approach For Cancermentioning

confidence: 99%

Soft Interaction in Liposome Nanocarriers for Therapeutic Drug Delivery

et al. 2016

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The development of smart nanocarriers for the delivery of therapeutic drugs has experienced considerable expansion in recent decades, with the development of new medicines devoted to cancer treatment. In this respect a wide range of strategies can be developed by employing liposome nanocarriers with desired physico-chemical properties that, by exploiting a combination of a number of suitable soft interactions, can facilitate the transit through the biological barriers from the point of administration up to the site of drug action. As a result, the materials engineer has generated through the bottom up approach a variety of supramolecular nanocarriers for the encapsulation and controlled delivery of therapeutics which have revealed beneficial developments for stabilizing drug compounds, overcoming impediments to cellular and tissue uptake, and improving biodistribution of therapeutic compounds to target sites. Herein we present recent advances in liposome drug delivery by analyzing the main structural features of liposome nanocarriers which strongly influence their interaction in solution. More specifically, we will focus on the analysis of the relevant soft interactions involved in drug delivery processes which are responsible of main behaviour of soft nanocarriers in complex physiological fluids. Investigation of the interaction between liposomes at the molecular level can be considered an important platform for the modeling of the molecular recognition processes occurring between cells. Some relevant strategies to overcome the biological barriers during the drug delivery of the nanocarriers are presented which outline the main structure-properties relationships as well as their advantages (and drawbacks) in therapeutic and biomedical applications.

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Section: Future Perspectives: the Theranostic Approach For Cancermentioning

confidence: 99%

Soft Interaction in Liposome Nanocarriers for Therapeutic Drug Delivery

et al. 2016

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“…Despite good sensitivity and selectivity, their drawbacks related to low reproducibility, complexity of enzyme immobilization process, activity vulnerability, and high cost have been limited their large-scale practical applications [3,4]. Much effort has been devoted to the design and exploitation of non-enzymatic sensors based on direct electrocatalysis of electrode materials through noble metals, metal alloys, transition metal oxides/hydroxides, or conductive polymers [1,5] assembled through both bottom-up and top-down, as well as mixed strategies, to avoid such issues [6]. Copper-based materials have been widely used both bottom-up and top-down, as well as mixed strategies, to avoid such issues [6].…”

Section: Introductionmentioning

confidence: 99%

Cu(I) Coordination Complex Precursor for Randomized CuOx Microarray Loaded on Carbon Nanofiber with Excellent Electrocatalytic Performance for Electrochemical Glucose Detection

Motoc

Cretu

Costişor

et al. 2019

Sensors

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A homoleptic ionic Cu(I) coordination complex that was based on 2,2′-biquinoline ligand functionalized with long alkyl chains (Cu(I)–C18) was used as a precursor to modify a carbon nanofiber paste electrode (Cu–C18/CNF). Randomized copper oxide microelectrode arrays dispersed within carbon nanofiber paste (CuOx/CNF) were obtained by electrochemical treatment of Cu–C18/CNF while using cyclic voltammetry (CV). The CuOx/CNF exhibited high electrocatalytic activity towards glucose oxidation at +0.6 V and +1.2 V vs. Ag/AgCl. Infrared Spectroscopy (FTIR) and scanning electron microscopy (SEM) characterized the electrodes composition. Cyclic voltammetry (CV), square wave-voltammetry (SWV), and multiple-pulsed amperometry (MPA) techniques provided optimized conditions for glucose oxidation and detection. A preconcentration step that involved 10 minutes accumulation at open circuit potential before SWV running led to the lowest limit of detection and the highest sensitivity for glucose detection (5419.77 µA·mM−1·cm−2 at + 1.1 V vs. Ag/AgCl) vs. Cu-based electrodes reported to date in literature.

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“…A review can be found where Calandra et al . discussed the complexity in polymer properties at nanoscale after introducing the particles in the polymer network …”

Section: Introductionmentioning

confidence: 99%

High oxygen permeable Zeolite‐4A poly(dimethylsiloxane) membrane for air separation

Prajapati

Kansara

Aswal

et al. 2019

J of Applied Polymer Sci

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High oxygen permeability with optimal selectivity of the membrane is required for advancement in air separation membrane technology. Zeolite 4A-PDMS composite membranes were prepared by incorporation of Zeolite 4A nanoscale crystals during the polymerization process of PDMS membrane using toluene and n-heptane solvents, and their oxygen gas permeability and selectivity were explored. Small angle neutron scattering (SANS) technique was further used to study the polymer chain conformation and structure of membranes influenced by Zeolite 4A loading. The intersegmental distance between polymer chains and polymer chain aggregation or clustering were found to be increased on increasing the Zeolite 4A content in the membranes. Increment in the O 2 permeability and O 2 /N 2 selectivity were observed for both type of membranes (toluene and n-heptane) with 1 wt% Zeolite 4A loading. The best performance result with O 2 /N 2 selectivity of 2.6, and O 2 permeability of 1052 Barrer was exhibited by PDMS/toluene membrane loaded with 1 wt% Zeolite 4A. The PDMS/toluene membranes with 10 wt% Zeolite 4A loading exhibited increased O 2 permeability of 1245 Barrer with a fair O 2 /N 2 selectivity of~1.7, while the PDMS/n-heptane membrane with the same loading exhibited excellent O 2 permeability of 6773 Barrer but lesser O 2 /N 2 selectivity of~1.2.

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How self-assembly of amphiphilic molecules can generate complexity in the nanoscale

Cited by 68 publications

References 123 publications

Soft Interaction in Liposome Nanocarriers for Therapeutic Drug Delivery

Soft Interaction in Liposome Nanocarriers for Therapeutic Drug Delivery

Cu(I) Coordination Complex Precursor for Randomized CuOx Microarray Loaded on Carbon Nanofiber with Excellent Electrocatalytic Performance for Electrochemical Glucose Detection

High oxygen permeable Zeolite‐4A poly(dimethylsiloxane) membrane for air separation

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