How safe and effective is the use of colchicine for the treatment of gout flares? A Cochrane Review summary with commentary

A case report of colchicine toxicity progressing from diarrhea to rhabdomyolysis: The probable role of interaction with ciprofloxacin

“…Also, low-dose colchicine was less likely to cause side effects. 6 Therefore, using colchicine in low doses is generally more The patient in this case used 1 mg/day of colchicine for 6 weeks. However, after the acute attack is resolved, the dose could be reduced to 0.5 mg/day for prophylaxis.…”

Non‐loading versus loading low‐dose colchicine in acute crystal‐associated arthritis: A double‐blinded randomized controlled study

“…13 Notably, a recent Cochrane review and its commentary concluded that there might be little or no evidence of important differences in treatment response between a high-and low-dose regimen, but the high-dose regimen clearly had a higher frequency of adverse events. 14,15 It is interesting that although acute CPP arthritis is very common in clinical practice, studies on the use of colchicine for it have been very limited, and most of them used the intravenous route 16,17 ; with oral colchicine recommendations usually following gout treatment. [18][19][20] This study aimed to compare the clinical efficacy and side effects between non-loading and loading low-dose colchicine in patients with acute crystal-associated arthritis.…”

“…The Thai Rheumatism Association recommends that colchicine should be given at 0.6 mg twice to four times daily for acute gouty arthritis 13 . Notably, a recent Cochrane review and its commentary concluded that there might be little or no evidence of important differences in treatment response between a high‐ and low‐dose regimen, but the high‐dose regimen clearly had a higher frequency of adverse events 14,15 …”