How Plants Avoid the Toxicity of Self‐Produced Defense Bioactive Compounds

Sirikantaramas, Supaart; Yamazaki, Mami; Saito, Kazuki

doi:10.1002/9781118794623.ch4

Cited by 5 publications

(2 citation statements)

References 63 publications

(67 reference statements)

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“…These mechanisms involve biosynthesis in the extracellular space or vacuolar lumen, conversion to non-toxic forms via glycosylation, and mutation of the target proteins of the metabolites, as summarized previously. 4,133) For example, some metabolites are biosynthesized at the apoplast or vacuolar lumen to avoid production in the cytosol, as reported for cannabinoids and anthocyanins. 134,135) Toxic compounds are often converted to less-toxic forms via glycosylation, and most glycosylated compounds are stored in the vacuole.…”

Section: Other Tolerance Mechanisms For Secondary Metabolitesmentioning

confidence: 99%

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Secondary metabolites in plants: transport and self-tolerance mechanisms

Shitan

2016

Bioscience, Biotechnology, and Biochemistry

175

100

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Plants produce a host of secondary metabolites with a wide range of biological activities, including potential toxicity to eukaryotic cells. Plants generally manage these compounds by transport to the apoplast or specific organelles such as the vacuole, or other self-tolerance mechanisms. For efficient production of such bioactive compounds in plants or microbes, transport and self-tolerance mechanisms should function cooperatively with the corresponding biosynthetic enzymes. Intensive studies have identified and characterized the proteins responsible for transport and self-tolerance. In particular, many transporters have been isolated and their physiological functions have been proposed. This review describes recent progress in studies of transport and self-tolerance and provides an updated inventory of transporters according to their substrates. Application of such knowledge to synthetic biology might enable efficient production of valuable secondary metabolites in the future.

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Section: Other Tolerance Mechanisms For Secondary Metabolitesmentioning

confidence: 99%

“…136) Detailed descriptions of self-tolerance mechanisms are available in recent reviews. 4,133) Other proteins involved in self-tolerance were identified from functional screening using yeast cells. For example, C. japonica produces the anti-bacterial alkaloid berberine to defend against pathogens.…”

Section: Other Tolerance Mechanisms For Secondary Metabolitesmentioning

confidence: 99%