How patients fare after anaesthesia for elective surgery: a survey of postoperative nausea and vomiting, pain and confusion

Lee, Yun Zhi; Lee, Ruth Qianyi; Thinn, Kyu Kyu; Poon, Keah How; Liu, Eugene Hern Choon

doi:10.11622/smedj.2015008

Cited by 12 publications

(10 citation statements)

References 16 publications

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“…Multiple previous studies on adults have shown that a preoperative history of motion sickness increases the risk of PONV . As such, we hypothesized that postdischarge motion during transportation may increase the risk of PDNV in children.…”

Section: Discussionmentioning

confidence: 99%

“…Multiple previous studies on adults have shown that a preoperative history of motion sickness increases the risk of PONV. 2,11,19,22,23 As such, we hypothesized that postdischarge motion during transportation may increase the risk of PDNV in children. To our knowledge, this was the first study to examine the length of the car ride home following discharge from the hospital in relation to PDNV.…”

Section: Postdischarge Transportationmentioning

confidence: 99%

See 1 more Smart Citation

Incidence and factors contributing to postdischarge nausea and vomiting in pediatric ambulatory surgical cases

Efune

Minhajuddin

Szmuk

2018

Pediatric Anesthesia

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Section: Discussionmentioning

confidence: 99%

Section: Postdischarge Transportationmentioning

confidence: 99%

Incidence and factors contributing to postdischarge nausea and vomiting in pediatric ambulatory surgical cases

Efune

Minhajuddin

Szmuk

2018

Pediatric Anesthesia

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“…It was consistent with rarity of opioids-related adverse effects. This could be attributed to generally low pain scores and the high threshold to prescribe opioid-based analgesia in our culture [13] . Subjectively, patient verbalized less IDC-related discomfort in the recovery room.…”

Section: Discussionmentioning

confidence: 86%

The effect of adjunct caudal block on postoperative analgesia in robot-assisted laparoscopic radical prostatectomy: A prospective randomized controlled, single blinded pilot study in a tertiary centre

Chen

Sim

Kan

2018

Asian Journal of Urology

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ObjectiveCaudal block provides satisfactory postoperative pain relief in lower abdominal operations. This pilot study explores its safety and effect on postoperative pain control in patients who underwent robot-assisted laparoscopic radical prostatectomy (RARP).MethodsFrom 2013 to 2014, 40 consecutive patients were randomized into two groups — one received caudal block using ropivacaine immediately after operation, the other received standard analgesia. Primary outcome measure was pain score based on 11-point Likert scale (0–10) recorded at recovery room, and at 6, 12, 24, 48, and 72 h after operation. All analgesic requirements, opioid-related adverse events and time to passage of flatus were examined.ResultsMean age of the two groups was similar (60.4 vs. 62.3 years, p = 0.33), as was American Society of Anaesthesiologists (ASA) class, body mass index (BMI) and operation times. No significant difference in median pain scores was reported in recovery room (2 vs. 3, p = 0.34), and at 6 h (2 vs. 2, p = 0.94), 12 h (0 vs. 0, p = 0.62), 24 h (1 vs. 0, p = 0.58), 48 h (1 vs. 0, p = 0.36) and 72 h (0 vs. 0, p = 0.78) postoperatively between control and caudal block groups, respectively. There was a higher mean opioid usage in the caudal block group which was not statistically significant. Although this was statistically insignificant while no significant difference in mean paracetamol usage was observed postoperatively. Median time to passage of flatus was similar (2.0 vs. 2.0 days, p = 0.97). There was one case of superficial wound infection and no opioid-related adverse events observed. Hospital stay was similar in both groups (2.5 vs. 2.5 days, p = 0.96).ConclusionAlthough a safe modality, caudal block in post RARP patients does not seem to improve pain control nor reduce analgesia requirements.

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“…10 But as the understanding deepens, more and more doctors and patients have realized that opioids were not safe. Related studies showed that there were several adverse reactions (respiratory depression, 11 addiction, 12 nausea and confusion 13 ) and the risk of hyperalgesia after opioid administration, which were positively correlated with dose. 14 In addition to analgesic effect, opioids could also activate the injury promoting mechanism in the body, leading to increased sensitivity of the body to pain, thus inducing opioid induced hyperalgesia (OIH) and chronic post-surgical pain (CPSP).…”

Section: Introductionmentioning

confidence: 99%

<p>Simultaneous Determination of Parecoxib and Its Metabolite Valdecoxib Concentrations in Beagle Plasma by UPLC-MS/MS and Application for Pharmacokinetics Study</p>

Li¹,

Zhu²,

Zhu³

et al. 2020

DDDT

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A method for the simultaneous determination of parecoxib and its metabolite valdecoxib in beagle plasma by UPLC-MS/MS was developed and validated. After the plasma was extracted by acetonitrile precipitation, the analytes were separated on an Acquity UPLC BEH C18 column (2.1 mm × 50 mm, 1.7 μm) using acetonitrile-formic acid as the mobile phase in gradient mode. The analytes were monitored by multiple reaction monitoring (MRM) in electrospray negative ion mode. The mass transfer pairs were m/z 368.97→119.01 for parecoxib, m/z 312.89→118.02 for valdecoxib, and m/z 379.98→316.02 for celecoxib (internal standard, IS). The correlation coefficients of parecoxib and valdecoxib ranged from 5 to 4000 ng/mL were greater than 0.9998. The recovery of parecoxib and valdecoxib was greater than 82.54%. The inter-and intra-day precision RSD values were 1.36~3.65% and 2.28~5.91%, respectively. The accuracy of RE values were −1.38%~1.96%. Finally, the matrix effect (ME) and stability were also within acceptable criteria. This method had been successfully applied to the pharmacokinetics of parecoxib and valdecoxib in beagle plasma after injection of parecoxib (1.33 mg/kg, intramuscular injection).

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How patients fare after anaesthesia for elective surgery: a survey of postoperative nausea and vomiting, pain and confusion

Cited by 12 publications

References 16 publications

Incidence and factors contributing to postdischarge nausea and vomiting in pediatric ambulatory surgical cases

Incidence and factors contributing to postdischarge nausea and vomiting in pediatric ambulatory surgical cases

The effect of adjunct caudal block on postoperative analgesia in robot-assisted laparoscopic radical prostatectomy: A prospective randomized controlled, single blinded pilot study in a tertiary centre

<p>Simultaneous Determination of Parecoxib and Its Metabolite Valdecoxib Concentrations in Beagle Plasma by UPLC-MS/MS and Application for Pharmacokinetics Study</p>

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