How Not to Make the Joint Extended Kalman Filter Fail with Unstructured Mechanistic Models
Cristovão Freitas Iglesias,
Miodrag Bolic
Abstract:The unstructured mechanistic model (UMM) allows for modeling the macro-scale of a phenomenon without known mechanisms. This is extremely useful in biomanufacturing because using the UMM for the joint estimation of states and parameters with an extended Kalman filter (JEKF) can enable the real-time monitoring of bioprocesses with unknown mechanisms. However, the UMM commonly used in biomanufacturing contains ordinary differential equations (ODEs) with unshared parameters, weak variables, and weak terms. When su… Show more
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