How nonbacterial osteomyelitis could be discriminated from tuberculosis in the early stages: the simple algorithm

Kostik, Mikhail M.; Копчак, О. Л.; Малетин, А. С.; Зорин, В. И.; Mushkin, Aleksandr

doi:10.1007/s10067-020-05174-5

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…Musculoskeletal tuberculosis, on the other hand, is unfortunately still posing a serious problem and often causes diagnostic challenge especially in developing countries with low incomes and limited health resources. It should be noted that the TST and interferon gamma release assay tests are not highly sensitive and specific for the diagnosis of bone tuberculosis [29,30].…”

Section: Discussionmentioning

confidence: 99%

Tumor-mimicking musculoskeletal infectious lesions: Experience of a single referral center

et al. 2022

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Introduction/Objectives. Bone and soft tissue infections might mimic bone and soft tissue tumors. Therefore, differential diagnosis is important to prevent errors in treatment. This report aims to present the data of patients with indistinct clinical and radiological findings mimicking benign and malignant bone and soft tissue tumors, which were later diagnosed as inflammatory infections. Methods. A retrospective chart review of the clinical, microbiological, radiologic, and pathologic findings of patients presented with a presumed diagnosis of a possible malignant lesion was performed. Results. The study included 21 patients with a median age (IQR) of 37 (1 month ? 72 years) years, and 13 (61%) patients were men. In total, 16 (76%) patients were admitted to the hospital with complaints of pain. The diagnoses were hydatid cyst, tuberculous osteomyelitis, cat-scratch disease, chronic osteomyelitis, subacute osteomyelitis, and soft tissue abscess. All patients were treated depending on the diagnosis of the lesion. Conclusion. There are chances of misdiagnosis due to shared common characteristics of tumoral and infectious lesions which might be mildly increased inflammatory markers with deeply seated non-mobile soft tissue masses and aggressive periosteal reactions and/or bone destruction patterns. So, each pseudotumoral lesion due to possible infectious causes should be histopathologically examined and correlated with other clinical and laboratory data in order to achieve a final diagnosis

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Section: Discussionmentioning

confidence: 99%

Tumor-mimicking musculoskeletal infectious lesions: Experience of a single referral center

et al. 2022

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Chronic recurrent multifocal osteomyelitis: diagnosis and treatment

Moreno-Mateo¹,

Perea

Onel

2020

Current Opinion in Pediatrics

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Purpose of review The aim of this article is to review recent findings regarding the diagnosis and treatment of chronic recurrent multifocal osteomyelitis (CRMO). Recent findings An adequate understanding of pathophysiology along with the new advances in MRI imaging make it possible to determine the extent of disease and establish early treatment. TNF-α inhibitors and bisphosphonates have shown to be a well-tolerated and efficient treatment for CRMO providing both symptomatic relief and normalization of bone morphology. Summary The results of recent studies suggest that a better knowledge of the genetic and molecular factors will allow early diagnosis and the development of more effective individualized treatments in the future.

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How nonbacterial osteomyelitis could be discriminated from tuberculosis in the early stages: the simple algorithm

Cited by 2 publications

References 44 publications

Tumor-mimicking musculoskeletal infectious lesions: Experience of a single referral center

Tumor-mimicking musculoskeletal infectious lesions: Experience of a single referral center

Chronic recurrent multifocal osteomyelitis: diagnosis and treatment

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