How much time in sedentary behavior is associated with probable sarcopenia in older adults?

Souza, Larissa Franciny de; Danielewicz, Ana Lúcia; Rech, Cassiano; d’Orsi, Eleonora; Mendonça, Vanessa Amaral; Lacerda, Ana Cristina Rodrigues; Avelar, Núbia Carelli Pereira de

doi:10.1016/j.gerinurse.2022.09.007

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…This is in line with the previous studies stating that low educational attainment [ 41 ], neuroticism [ 42 ], low testosterone levels [ 43 ], short stature [ 44 ], high alcohol [ 45 ], processed meat [ 46 ] and salt [ 47 ] intake, sedentary behavior (such as watching television) [ 48 ], smoking and physical inactivity [ 49 ] are associated with an increased risk of sarcopenia or low muscle strength, whereas coffee, magnesium, potassium, protein, vitamin D, water, oil fish, fruits and vegetables intake [ 46 , 50 , 51 , 52 , 53 , 54 ] have protective effects against sarcopenia.…”

Section: Discussionsupporting

confidence: 92%

Identification and Characterization of Genomic Predictors of Sarcopenia and Sarcopenic Obesity Using UK Biobank Data

et al. 2023

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The substantial decline in skeletal muscle mass, strength, and gait speed is a sign of severe sarcopenia, which may partly depend on genetic risk factors. So far, hundreds of genome-wide significant single nucleotide polymorphisms (SNPs) associated with handgrip strength, lean mass and walking pace have been identified in the UK Biobank cohort; however, their pleiotropic effects on all three phenotypes have not been investigated. By combining summary statistics of genome-wide association studies (GWAS) of handgrip strength, lean mass and walking pace, we have identified 78 independent SNPs (from 73 loci) associated with all three traits with consistent effect directions. Of the 78 SNPs, 55 polymorphisms were also associated with body fat percentage and 25 polymorphisms with type 2 diabetes (T2D), indicating that sarcopenia, obesity and T2D share many common risk alleles. Follow-up bioinformatic analysis revealed that sarcopenia risk alleles were associated with tiredness, falls in the last year, neuroticism, alcohol intake frequency, smoking, time spent watching television, higher salt, white bread, and processed meat intake; whereas protective alleles were positively associated with bone mineral density, serum testosterone, IGF1, and 25-hydroxyvitamin D levels, height, intelligence, cognitive performance, educational attainment, income, physical activity, ground coffee drinking and healthier diet (muesli, cereal, wholemeal or wholegrain bread, potassium, magnesium, cheese, oily fish, protein, water, fruit, and vegetable intake). Furthermore, the literature data suggest that single-bout resistance exercise may induce significant changes in the expression of 26 of the 73 implicated genes in m. vastus lateralis, which may partly explain beneficial effects of strength training in the prevention and treatment of sarcopenia. In conclusion, we have identified and characterized 78 SNPs associated with sarcopenia and 55 SNPs with sarcopenic obesity in European-ancestry individuals from the UK Biobank.

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Section: Discussionsupporting

confidence: 92%

Identification and Characterization of Genomic Predictors of Sarcopenia and Sarcopenic Obesity Using UK Biobank Data

et al. 2023

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“…For example, de Souza et al (2022) found a prevalence of probable sarcopenia of 64.1% for older women from the city of Balneário Arroio do Silva in the state of Santa Catarina, Brazil [31]. Another study conducted by de Souza et al (2022) observed a prevalence of probable sarcopenia of 42.0% in older Brazilian women using data from a study with probabilistic sampling carried out in Florianópolis in the state of Santa Catarina, Brazil [32]. Swan, Warters and O'Sullivan (2022) observed that 26.1% of participants aged 60 years and over from the English Longitudinal Study of Ageing (ELSA) met the criteria for probable sarcopenia based on poor performance in 5XSST [33].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of sarcopenia in older women and level of agreement between the diagnostic instruments proposed by the European Working Group on Sarcopenia in Older People 2 (EWGSOP2)

Sutil

Parentoni

Teixeira

et al. 2023

BMC Musculoskelet Disord

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Background The European Working Group on Sarcopenia in Older People 2 (EWGSOP2) proposed the use of different diagnostic tools to assess sarcopenia. This study aimed to determine prevalence rates of sarcopenia according to the diagnostic instruments proposed by EWGSOP2 and to assess their level of agreement in older Brazilian women. Methods A cross-sectional study with 161 community-dwelling older Brazilian women. Probable sarcopenia was assessed through Handgrip Strength (HGS) and the 5-times sit-to-stand test (5XSST). In addition to reduced strength, Appendicular Skeletal Muscle Mass (ASM) (obtained by Dual-energy X-ray absorptiometry) and ASM/height² were considered for diagnosis confirmation. Sarcopenia severity was determined by reduced muscle strength and mass and poor functional performance assessed by Gait Speed (GS), Short Physical Performance Battery (SPPB), and Timed Up and Go test (TUG). McNemar’s test and Cochran’s Q-test were used to compare sarcopenia prevalence. Cohen’s Kappa and Fleiss’s Kappa tests were used to assess the level of agreement. Results The prevalence of probable sarcopenia was significantly different (p < 0.05) when using HGS (12.8%) and 5XSST (40.6%). Regarding confirmed sarcopenia, the prevalence was lower when using ASM/height² than with ASM. Regarding severity, the use of SPPB resulted in a higher prevalence in relation to GS and TUG. Conclusion There were differences in the prevalence rates of sarcopenia and low agreement between the diagnostic instruments proposed by the EWGSOP2. The findings suggest that these issues must be considered in the discussion on the concept and assessment of sarcopenia, which could ultimately help to better identify patients with this disease in different populations.

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“…Participating in regular exercise, such as resistance training and aerobic activities, can stimulate muscle protein synthesis, increase insulin sensitivity, and trigger the release of growth factors that support muscle growth and repair [57]. By contrast, sedentary behavior limits muscle contractile stimulation, energy expenditure, and muscle metabolism, leading to an imbalance between protein synthesis and breakdown [31,59]. Therefore, limiting sedentary behavior can improve muscle synthesis and growth, contributing to a lower risk of sarcopenia [59].…”

Section: Discussionmentioning

confidence: 99%

“…By contrast, sedentary behavior limits muscle contractile stimulation, energy expenditure, and muscle metabolism, leading to an imbalance between protein synthesis and breakdown [31,59]. Therefore, limiting sedentary behavior can improve muscle synthesis and growth, contributing to a lower risk of sarcopenia [59]. Moreover, adequate fruit and vegetable intake can have a synergistic effect that promotes muscle and physical performance in older adults [57,58].…”

Section: Discussionmentioning

confidence: 99%

Physical Activity, Sedentary Behavior, Fruit and Vegetable Consumption, and Sarcopenia in Older Chinese Adults: A Cross-Sectional Study

Zhang

2023

Nutrients

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Purpose: The purpose of this study was to investigate the association between moderate to vigorous physical activity (MVPA), sedentary behavior, fruit and vegetable intake, and the risk of sarcopenia among older Chinese adults. Methods: This cross-sectional study enrolled 5418 older Chinese adults who participated in the Study on Global Aging and Adult Health (SAGE). Participants reported information about their physical activity, sedentary behavior, and dietary habits (fruit and vegetable intake). Sarcopenia was defined as the presence of low skeletal muscle mass and either a slow gait speed or weak handgrip strength. A multiple logistic regression model was employed to determine the relationship between MVPA, sedentary behavior, fruit and vegetable intake, and the risk of sarcopenia. Results: Only 32.63% of participants met all three recommendations (for MVPA, sedentary behavior, and fruit and vegetable intake). Compared with meeting none of the recommendations, meeting all three recommendations was associated with a lower risk of sarcopenia (OR = 0.63, 95% CI = 0.41–0.98). Moreover, meeting the recommendation for sufficient fruit and vegetable intake (OR = 0.69, 95% CI = 0.58–0.83), MVPA and fruit/vegetable intake (OR = 0.67, 95% CI = 0.52–0.86), and sedentary behavior and fruit/vegetable intake (OR = 0.69, 95% CI = 0.48–0.98) was associated with a lower risk of sarcopenia. Conclusion: Our findings indicate that in this large representative sample of older Chinese adults, meeting lifestyle recommendations for MVPA, sedentary behavior, and fruit and vegetable intake protected against sarcopenia.

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How much time in sedentary behavior is associated with probable sarcopenia in older adults?

Cited by 9 publications

References 26 publications

Identification and Characterization of Genomic Predictors of Sarcopenia and Sarcopenic Obesity Using UK Biobank Data

Identification and Characterization of Genomic Predictors of Sarcopenia and Sarcopenic Obesity Using UK Biobank Data

Prevalence of sarcopenia in older women and level of agreement between the diagnostic instruments proposed by the European Working Group on Sarcopenia in Older People 2 (EWGSOP2)

Physical Activity, Sedentary Behavior, Fruit and Vegetable Consumption, and Sarcopenia in Older Chinese Adults: A Cross-Sectional Study

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