A 65-year-old woman with dialytic chronic kidney disease was admitted to our unit for treatment of a sepsis of urinary focus. Her medical history included hypertension, type 2 diabetes mellitus and dyslipidemia. Her home medications were furosemide, amlodipine, atenolol, hydralazine, omeprazole, aspirin, losartan, simvastatin and NPH insulin. Electrocardiogram (ECG) at admission showed a sinus rhythm with left bundle branch block. A real-time ultrasound-guided central venous catheter cannulation was attempted through the right internal jugular vein with the patient connected to a monitor that recorded her ECG and blood oxygen saturation. Before performing the cannulation, her heart rate was averaging 70-80 beats per minute. During the process of guidewire insertion, her heart rate suddenly dropped to 35 beats per minute, and the ECG on the monitor displayed a pattern compatible with a complete heart block. A stat ECG was obtained (Fig.