How much epigenetics and quantitative trait loci (QTL) mapping tell us about parasitism maintenance and resistance/susceptibility to hosts

Prado, Aline Marrara; Maia, Bárbara Maria Cerqueira; Ueta, Marlene Tiduko; Cabral, Fernanda Janku

doi:10.1016/j.bbadis.2021.166214

Cited by 3 publications

(2 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This further supports that rDNA appears to be a critical but rare methylomic target during prenatal development 107 . Given that neonatal badger cubs suffer impaired nutrition and growth due to coccidia infection 55 , leading to > 60% mortality in cohorts during dry years 56 , future research should investigate whether maternal malnutrition triggers rDNA methylation promoting genes linked to greater coccidiosis resistance or lower coccidiosis morbidity 108,109 .…”

Section: S Rdna Can Translate Environmental Stress Into Phenotypic St...mentioning

confidence: 99%

Pre-implantation genome-wide methylation enables environmental adaptation in a social meso-carnivore

Hung,

Tsai,

Newman

et al. 2024

Preprint

View full text Add to dashboard Cite

Many wild populations are increasingly stressed by rapid climatic change. While behavioural plasticity can enable limited tactical adaptive responses, standing genetic variation limits the species’ capacity to respond to climate change velocity. Epigenetic modification may provide a more rapid and plastic adaptive mechanism, but has been little studied in wild-living animals. Here we investigated CpG methylation during the pre-natal and early-life development of 95 European badger cubs between 2003 and 2011). During 10-months of delayed pre-implantation variability in precipitation between previous year’s February and April was the top determinant of methylation patterns among neonates, followed by mean temperature and temperature variability. Among the 4,641 significant weather-associated CpG sites, most occurred in the 47S rDNA region. Methylation of 47S rDNA was also associated with early-life weight, implying a mechanism that relays environmental stress to phenotypic stress. We also detected evidence for predictive adaptive response. Among the 1,641 CpG sites associated with early-life weight, pathways were associated with early-life growth, immune regulation, and to the development of aggression for competitive access to weather-limited food resources were over-represented. We conclude that a species’ epigenetics can have an important role in adaptive plasticity to environmental changes with important implications for biodiversity conservation and management.

show abstract

Section: S Rdna Can Translate Environmental Stress Into Phenotypic St...mentioning

confidence: 99%

Pre-implantation genome-wide methylation enables environmental adaptation in a social meso-carnivore

Hung,

Tsai,

Newman

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Biotic factors, including predators, competitors, and parasites (e.g., Forsman and Martin, 2009 ) can also be stressful to organisms. In the case of parasites, both the internal and external environments of a parasitic host dictate the outcome of their infection, resistance, susceptibility, and transmission ( Prado et al, 2021 ). Moreover, the internal conditions of parasitic hosts may constitute a greater constraint upon survival than external conditions ( Tinsley, 1999 ).…”

Section: Introductionmentioning

confidence: 99%

Redox-Sensitive VDAC: A Possible Function as an Environmental Stress Sensor Revealed by Bioinformatic Analysis

et al. 2021

View full text Add to dashboard Cite

Voltage-dependent anion-selective channel (VDAC) allows the exchange of small metabolites and inorganic ions across the mitochondrial outer membrane. It is involved in complex interactions that regulate mitochondrial and cellular functioning. Many organisms have several VDAC paralogs that play distinct but poorly understood roles in the life and death of cells. It is assumed that such a large diversity of VDAC-encoding genes might cause physiological plasticity to cope with abiotic and biotic stresses known to impact mitochondrial function. Moreover, cysteine residues in mammalian VDAC paralogs may contribute to the reduction–oxidation (redox) sensor function based on disulfide bond formation and elimination, resulting in redox-sensitive VDAC (rsVDAC). Therefore, we analyzed whether rsVDAC is possible when only one VDAC variant is present in mitochondria and whether all VDAC paralogs present in mitochondria could be rsVDAC, using representatives of currently available VDAC amino acid sequences. The obtained results indicate that rsVDAC can occur when only one VDAC variant is present in mitochondria; however, the possibility of all VDAC paralogs in mitochondria being rsVDAC is very low. Moreover, the presence of rsVDAC may correlate with habitat conditions as rsVDAC appears to be prevalent in parasites. Thus, the channel may mediate detection and adaptation to environmental conditions.

show abstract

Probiotics as a strategy for addressing helminth infections in low-income countries: Working smarter rather than richer

Schemczssen-Graeff,

Silva,

de Freitas

et al. 2024

Biochemical Pharmacology

View full text Add to dashboard Cite

How much epigenetics and quantitative trait loci (QTL) mapping tell us about parasitism maintenance and resistance/susceptibility to hosts

Cited by 3 publications

References 116 publications

Pre-implantation genome-wide methylation enables environmental adaptation in a social meso-carnivore

Pre-implantation genome-wide methylation enables environmental adaptation in a social meso-carnivore

Redox-Sensitive VDAC: A Possible Function as an Environmental Stress Sensor Revealed by Bioinformatic Analysis

Probiotics as a strategy for addressing helminth infections in low-income countries: Working smarter rather than richer

Contact Info

Product

Resources

About