How Much Do Clinical and Microperimetric Findings Affect Reading Speed in Low Vision Patients with Age-related Macular Degeneration?

Altınbay, Deniz; İdil, Aysun; Şahlı, Esra

doi:10.1080/02713683.2021.1896740

Cited by 8 publications

(7 citation statements)

References 38 publications

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“…Reading speed and comprehension are substantially reduced in AMD [ 21 ], and reading disabilities have a significant impact on quality of life in AMD [ 22 ]. Furthermore, microperimetry revealed correlations of reading speed with fixation stability, foveal absolute scotoma, reading acuity, and sociodemographic characteristics [ 23 ]. Similar findings are known from postoperative outcomes after the peeling of epiretinal membranes, where an increase in reading visual acuity and critical print-size was shown in patients despite unchanged BCVA [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Switching to Brolucizumab in Neovascular Age-Related Macular Degeneration Incompletely Responsive to Ranibizumab or Aflibercept: Real-Life 6 Month Outcomes

Haensli

Pfister

Garweg

2021

JCM

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Purpose: The aim of this study was to evaluate the effect of switching treatment in eyes with neovascular age-related macular degeneration (nAMD) and treatment intervals of ≤6 weeks to brolucizumab. Methods: In this prospective series, eyes with persisting retinal fluid under aflibercept or ranibizumab every 4–6 weeks were switched to brolucizumab. Visual acuity (BCVA), reading acuity (RA), treatment intervals, central subfield thickness (CST), and the presence of intra- and subretinal fluid were recorded over 6 months. Results: Seven of 12 eyes completed the 6 month follow-up and received 4.4 ± 0.5 brolucizumab injections within 28.0 ± 2.8 weeks. Treatment intervals increased from 5.3 ± 0.9 weeks to 9.0 ± 2.8 weeks (95% confidence interval of extension (CI): 1.6 to 5.9). BCVA improved from 67.8 ± 7.2 to 72.2 ± 7.5 (95% CI: −0.3 to 9.1) ETDRS letters, RA improved from 0.48 ± 0.15 to 0.31 ± 0.17 LogRAD (95% CI: 0.03 to 0.25), and CST improved from 422.1 ± 97.3 to 353.6 ± 100.9 µm (95% CI: −19.9 to 157.1). Treatment was terminated early in five eyes (two intraocular inflammations with vascular occlusion without vision loss, one stroke, and two changes in the treatment plan). Conclusions: Improvement in visual performance and longer treatment intervals in our series over 6 months indicate the potential of brolucizumab to reduce the treatment burden in nAMD, while two instances of intraocular inflammation were encountered.

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Section: Discussionmentioning

confidence: 99%

Switching to Brolucizumab in Neovascular Age-Related Macular Degeneration Incompletely Responsive to Ranibizumab or Aflibercept: Real-Life 6 Month Outcomes

Haensli

Pfister

Garweg

2021

JCM

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“…However, in some patients the retinal uid is detected in parafovea and as a result, neither CRT nor VA are severely affected. Microperimetry 34 and functional tests which consider the AMD patients' slow information transfer rate 25 , may provide complementary indices of macular visual function and progression of the disease. Finally, functional reading was not assessed using formally standardized passages, such as IReST, which are now available in Greek 35 .…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of anti-VEGF treatment in wet Age-related Macular Degeneration; an evaluation of silent reading performance with eye movement analysis

Ktistakis

Simos

Tsilimbaris

et al. 2022

Preprint

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Purpose: To evaluate silent reading performance by means of eye fixation analysis before and after anti-VEGF treatment in wet AMD (wAMD) patients.Methods: Twenty wAMD patients who underwent anti-VEGF treatment, in one eye, served as the AMD group. Twenty adults without ocular pathology, served as the control group. Central Retinal Thickness (CRT) and near visual acuity (VA) were assessed at baseline and after 3-4 months following their first visit. Reading performance was evaluated using short passages of 0.4 logMAR print size at 40 cm distance. Eye movements were recorded using a video eyetracker. Data analysis included computation of reading speed, fixation duration, number of fixations, and percentage of regressions.Results: In the AMD group, silent reading speed in the treated eye correlated well with CRT reduction and improved significantly by an average of 15.9±28.5 wpm (p=0.041). This improvement was accompanied by an average reduction of 0.24±0.38 in fixations per word (p=0.023). The corresponding improvement in monocular VA was not statistically significant, as was the case with other eye fixation parameters. Conclusion: VA tests may underestimate the potential therapeutic effects following anti-VEGF treatment. Evaluating silent reading performance and eye fixation parameters may better characterize the effectiveness of therapeutic approaches in wAMD patients.

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“…explored the relationship between scotoma size and reading speed in observers with subfoveal occult choroidal neovascularization in AMD and found there was a significant correlation between scotoma size and reading speed using a German‐language reading test, Radner Lesetest; similar to the relationship we found with RSVP but not with scrolling. Altinbay et al 18 . explored the relationship between MRS while reading MNRead standardised cards and PRL eccentricities.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that the PRL diameter, defined as the bivariate contour ellipse area (BCEA) used to describe 63%, 68% or 95% of the retinal loci used for fixation, ranges from 1° to 9°, 2 where the larger the BCEA the greater the fixation instability. Fixation stability has also been correlated with reading speed 18,19 and correct reading rate 20 …”

Section: Introductionmentioning

confidence: 99%

Exploration of dynamic text presentations in bilateral central vision loss

Bowman

Ross

Bex

et al. 2021

Ophthalmic Physiologic Optic

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Purpose Dynamic text presentation methods may improve reading ability in patients with central vision loss (CVL) by eliminating the need for accurate eye movements. We compared rapid serial visual presentation (RSVP) and horizontal scrolling text presentation (scrolling) on reading rate and reading acuity in CVL observers and normally‐sighted controls with simulated CVL (simCVL). Methods CVL observers’ (n = 11) central scotomas and preferred retinal loci (PRL) for each eye were determined with MAIA microperimetry and fixation analysis. SimCVL controls (n = 16) used 4° inferior eccentric viewing, enforced with an Eyelink eye‐tracker. Observers read aloud 4‐word phrases randomly drawn from the MNREAD sentences. Six font sizes (0.50–1.30 logMAR) were tested with the better near acuity eye and both eyes of CVL observers. Three font sizes (0.50–1.00 logMAR) were tested binocularly in simCVL controls. Text presentation duration of each word for RSVP or drift speed for scrolling was varied to determine reading rate, defined as 50% of words read correctly. In a subset of CVL observers (n = 7), relationships between PRL eccentricity, reading threshold and rate were explored. Results SimCVL controls demonstrated significantly faster reading rates for RSVP than scrolling text (p < 0.0001), and there was a significant main effect of font size (p < 0.0001). CVL patients demonstrated no significant differences in binocular reading rate between font sizes (p = 0.12) and text presentation (p = 0.25). Similar results were seen under monocular conditions. Reading acuity for RSVP and scrolling worsened with increasing PRL eccentricity (μ = 4.5°, p = 0.07). RSVP reading rate decreased significantly with increasing eccentricity (p = 0.02). Conclusions Consistent with previous work, reading acuity worsened with increasing PRL eccentricity. RSVP and scrolling text presentations significantly affected reading rate in simCVL, but not in CVL observers, suggesting that simCVL results may not generalise to pathological CVL.

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How Much Do Clinical and Microperimetric Findings Affect Reading Speed in Low Vision Patients with Age-related Macular Degeneration?

Cited by 8 publications

References 38 publications

Switching to Brolucizumab in Neovascular Age-Related Macular Degeneration Incompletely Responsive to Ranibizumab or Aflibercept: Real-Life 6 Month Outcomes

Switching to Brolucizumab in Neovascular Age-Related Macular Degeneration Incompletely Responsive to Ranibizumab or Aflibercept: Real-Life 6 Month Outcomes

Effectiveness of anti-VEGF treatment in wet Age-related Macular Degeneration; an evaluation of silent reading performance with eye movement analysis

Exploration of dynamic text presentations in bilateral central vision loss

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