How much blood is really lost in total knee arthroplasty?

Sehat, Khosrow; Evans, R.; Newman, John H.

doi:10.1016/s0968-0160(00)00047-8

Cited by 351 publications

(159 citation statements)

References 5 publications

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“…In these studies, however, the blood loss was measured as the loss during surgery plus the drainage volume. Since there may also have been hidden losses as a result of hemolysis and tissue extravasation, which would not have shown on drain output, the true effect of tranexamic acid on blood loss was not clear20). A true estimate of total blood loss can be more appropriately made using a hemoglobin balance method2021).…”

Section: Introductionmentioning

confidence: 99%

Effect of Tranexamic Acid on Blood Loss and Blood Transfusion Reduction after Total Knee Arthroplasty

Seol

Seon

Lee

et al. 2016

Knee Surg Relat Res

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PurposeTotal knee arthroplasty (TKA) accompanies the risk of bleeding and need for transfusion. There are several methods to reduce postoperative blood loss and blood transfusion. One such method is using tranexamic acid during TKA. The purpose of this study was to confirm whether tranexamic acid reduces postoperative blood loss and blood transfusion after TKA.Materials and MethodsA total of 100 TKA patients were included in the study. The tranexamic acid group consisted of 50 patients who received an intravenous injection of tranexamic acid. The control included 50 patients who received a placebo injection. The amounts of drainage, postoperative hemoglobin, and transfusion were compared between the groups.ResultsThe mean amount of drainage was lower in the tranexamic acid group (580.6±355.0 mL) than the control group (886.0±375.5 mL). There was a reduction in the transfusion rate in the tranexamic acid group (48%) compared with the control group (64%). The hemoglobin level was higher in the tranexamic acid group than in the control group at 24 hours postoperatively. The mean units of transfusion were smaller in the tranexamic acid group (0.76 units) than in the control group (1.28 units).ConclusionsOur data suggest that intravenous injection of tranexamic acid decreases the total blood loss and transfusion after TKA.

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Section: Introductionmentioning

confidence: 99%

Effect of Tranexamic Acid on Blood Loss and Blood Transfusion Reduction after Total Knee Arthroplasty

Seol

Seon

Lee

et al. 2016

Knee Surg Relat Res

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“…However, TKA is associated with significant blood loss because of extensive dissections through bony and fibrotic tissue [1,2]. Blood loss is a common problem during and after TKA, which can result in the need for transfusions, postoperative anemia, and increased costs for health care [3].…”

Section: Introductionmentioning

confidence: 99%

Is fibrin sealant effective and safe in total knee arthroplasty? A meta-analysis of randomized trials

et al. 2014

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The objective of this study was to evaluate the efficacy and safety of fibrin sealant in patients following total knee arthroplasty (TKA). A comprehensive literature search of the electronic databases PubMed, MEDLINE, Web of Science, and Cochrane Library for published randomized controlled trials (RCTs) was undertaken. The evidence base was critically appraised using a tool from the Cochrane Bone, Joint and Muscle Trauma Group. Eight RCTs involving 641 patients were included. The use of fibrin sealant significantly reduced postoperative drainage (weighted mean difference (WMD) −346, 95% confidence interval (CI) −496.29 to −197.54, P < 0.00001) and blood transfusions (risk ratio (RR) 0.47, 95% CI 0.35 to 0.63, P < 0.00001) and led to a significant improvement in the range of motion (WMD 16.59, 95% CI 6.92 to 26.25, P = 0.0008). However, using fibrin sealant did not significantly reduced total blood loss (WMD −305.25, 95% CI −679.44 to 68.95, P = 0.11). Regarding complications, there were no significant differences in any adverse events, fever, infection, or hematoma among the study groups. In conclusion, the present meta-analysis indicates that the use of fibrin sealant was effective and safe as a hemostatic therapy for patients with TKA.

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“…The authors saw little blood loss following surgery and therefore, any postoperative blood loss was ignored. The method of Sehat et al 10 was used to calculate the HBL.…”

Section: Orthopedic Gen Hosp Agios Andreas Patras Greecementioning

confidence: 99%

Hidden Blood Loss in Spine Surgery for A1-A3 thoracolumbar Fractures. Comparison Between Three Approaches

Korovessis

2018

Journal of Investigative Surgery

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How much blood is really lost in total knee arthroplasty?

Cited by 351 publications

References 5 publications

Effect of Tranexamic Acid on Blood Loss and Blood Transfusion Reduction after Total Knee Arthroplasty

Effect of Tranexamic Acid on Blood Loss and Blood Transfusion Reduction after Total Knee Arthroplasty

Is fibrin sealant effective and safe in total knee arthroplasty? A meta-analysis of randomized trials

Hidden Blood Loss in Spine Surgery for A1-A3 thoracolumbar Fractures. Comparison Between Three Approaches

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