How moving visual stimuli modulate the activity of the substantia nigra pars reticulata

Berényi, Antal; Gombkötő, Péter; Farkas, Anita; Paróczy, Zsuzsanna; Márkus, Zita; Averkin, Robert G.; Benedek, György; Nagy, Attila

doi:10.1016/j.neuroscience.2009.07.031

Cited by 3 publications

(2 citation statements)

References 73 publications

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“…Sensory and motor information from the cerebral cortex are elaborated by the basal ganglia network and converge on the SNpr, where they are integrated and re‐routed to associative and motor circuits [6,7]. The inhibitory SNpr neurons project to the thalamus in the forebrain, where they control voluntary movement trough the thalamo‐cortical circuits, but also tegmentum and the superior colliculus (SC) to control eye movement and reward‐dependent saccades [4,7–13].…”

Section: Subtypes Of Gabaergic and Glutamatergic Neurons Associated Wmentioning

confidence: 99%

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Diversity and development of local inhibitory and excitatory neurons associated with dopaminergic nuclei

Morello

Partanen

2015

FEBS Letters

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Edited by Wilhelm JustKeywords: Dopamine GABA Glutamate Substantia nigra Ventral tegmental area Rostromedial tegmental nucleus a b s t r a c t For regulation of voluntary movement and motivation the midbrain dopaminergic system receives input from a variety of brain regions. Often this input is mediated by local non-dopaminergic neurons within or closely associated with the dopaminergic nuclei. In addition to the dopaminergic neurons, some of these non-dopaminergic neurons also send functionally important output from the ventral midbrain to forebrain targets. The aim of this review is to introduce subtypes of GABAergic and glutamatergic neurons, which are located in the dopaminergic nuclei or the adjacent brainstem and are important for the regulation of the dopaminergic pathways. In addition, we discuss recent studies beginning to reveal mechanisms for their development, which may hold the key to understanding the diversity of these neurons.

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Section: Subtypes Of Gabaergic and Glutamatergic Neurons Associated Wmentioning

confidence: 99%

“…The inhibitory SNpr neurons project to the thalamus in the forebrain, where they control voluntary movement trough the thalamo-cortical circuits, but also tegmentum and the superior colliculus (SC) to control eye movement and reward-dependent saccades [4,[7][8][9][10][11][12][13].…”

Section: Subtypes Of Gabaergic and Glutamatergic Neurons Associated Wmentioning

confidence: 99%

Diversity and development of local inhibitory and excitatory neurons associated with dopaminergic nuclei

Morello

Partanen

2015

FEBS Letters

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Pathways for Naturalistic Looking Behavior in Primate II. Superior Colliculus Integrates Parallel Top-down and Bottom-up Inputs

Veale,

Takahashi

2024

Neuroscience

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The Substantia Nigra Conveys Target-Dependent Excitatory and Inhibitory Outputs from the Basal Ganglia to the Thalamus

Antal

Beneduce

Regehr

2014

Journal of Neuroscience

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The basal ganglia (BG), which influence cortical activity via the thalamus, play a major role in motor activity, learning and memory, sensory processing, and many aspects of behavior. The substantia nigra (SN) consists of GABAergic neurons of the pars reticulata that inhibit thalamic neurons and provide the primary output of the BG, and dopaminergic neurons of the pars compacta that modulate thalamic excitability. Little is known about the functional properties of the SN3thalamus synapses, and anatomical characterization has been controversial. Here we use a combination of anatomical, electrophysiological, genetic, and optogenetic approaches to re-examine these synaptic connections in mice. We find that neurons in the SN inhibit neurons in the ventroposterolateral nucleus of the thalamus via GABAergic synapses, excite neurons in the thalamic nucleus reticularis, and both excite and inhibit neurons within the posterior nucleus group. Glutamatergic SN neurons express the vesicular glutamate receptor transporter vGluT2 and receive inhibitory synapses from striatal neurons, and many also express tyrosine hydroxylase, a marker of dopaminergic neurons. Thus, in addition to providing inhibitory outputs, which is consistent with the canonical circuit, the SN provides glutamatergic outputs that differentially target thalamic nuclei. This suggests that an increase in the activity of glutamatergic neurons in the SN allows the BG to directly excite neurons in specific thalamic nuclei. Elucidating an excitatory connection between the BG and the thalamus provides new insights into how the BG regulate thalamic activity, and has important implications for understanding BG function in health and disease.

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How moving visual stimuli modulate the activity of the substantia nigra pars reticulata

Cited by 3 publications

References 73 publications

Diversity and development of local inhibitory and excitatory neurons associated with dopaminergic nuclei

Diversity and development of local inhibitory and excitatory neurons associated with dopaminergic nuclei

Pathways for Naturalistic Looking Behavior in Primate II. Superior Colliculus Integrates Parallel Top-down and Bottom-up Inputs

The Substantia Nigra Conveys Target-Dependent Excitatory and Inhibitory Outputs from the Basal Ganglia to the Thalamus

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