How might the longer-than-expected lifetimes of hip and knee replacements affect clinical practice?

Fowler, Timothy; Blom, Ashley W; Sayers, Adrian; Whitehouse, Michael R; Evans, Jonathan

doi:10.1080/17434440.2019.1654857

Cited by 1 publication

(1 citation statement)

References 15 publications

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“…In addition, a metallic implant is usually installed in the body for a long period of time. Depending on the age of the patient at initial implantation, re-implantation of an endoprosthesis may be required after 10–15 years (knee), 15–20 years (hip), or 10 years (shoulder), depending on the site of implantation [ 7 , 8 ]. Such reoperations pose enormous risks to the health of patients, especially at advanced ages.…”

Section: Introductionmentioning

confidence: 99%

The Mineralization of Various 3D-Printed PCL Composites

Egorov

Riedel

Vinke

et al. 2022

JFB

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In this project, different calcification methods for collagen and collagen coatings were compared in terms of their applicability for 3D printing and production of collagen-coated scaffolds. For this purpose, scaffolds were printed from polycaprolactone PCL using the EnvisionTec 3D Bioplotter and then coated with collagen. Four different coating methods were then applied: hydroxyapatite (HA) powder directly in the collagen coating, incubation in 10× SBF, coating with alkaline phosphatase (ALP), and coating with poly-L-aspartic acid. The results were compared by ESEM, µCT, TEM, and EDX. HA directly in the collagen solution resulted in a pH change and thus an increase in viscosity, leading to clumping on the scaffolds. As a function of incubation time in 10× SBF as well as in ALP, HA layer thickness increased, while no coating on the collagen layer was apparently observed with poly-L-aspartic acid. Only ultrathin sections and TEM with SuperEDX detected nano crystalline HA in the collagen layer. Exclusively the incubation in poly-L-aspartic acid led to HA crystals within the collagen coating compared to all other methods where the HA layers formed in different forms only at the collagen layer.

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Section: Introductionmentioning

confidence: 99%