How microRNA172 affects fruit growth in different species is dependent on fruit type

Yao, Jia‐Long; Tomes, Sumathi; Xu, Juan; Gleave, Andrew P.

doi:10.1080/15592324.2016.1156833

Cited by 43 publications

(26 citation statements)

References 20 publications

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“…Its target gene AP2 is a negative regulator of fruit ripening with evidence that knock-down of SlAP2a leads to orange color, split open and bumpy surface of fruits in tomato 80 . Moreover, recent studies found that the miR172- AP2 pathway affects fruit size in different species depending on fruit type 57 (Fig. 5a ).…”

Section: Small Rna Research In Horticultural Plantsmentioning

confidence: 87%

Small RNAs, emerging regulators critical for the development of horticultural traits

et al. 2018

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Small RNAs (sRNAs) have been recently recognized as key genetic and epigenetic regulators in various organisms, ranging from the modification of DNA and histone methylations to the modulation of the abundance of coding or non-coding RNAs. In plants, major regulatory sRNAs are classified as respective microRNA (miRNA) and small interfering RNA (siRNA) species, with the former primarily engaging in posttranscriptional regulation while the latter in transcriptional one. Many of these characterized sRNAs are involved in regulation of diverse biological programs, processes, and pathways in response to developmental cues, environmental signals/stresses, pathogen infection, and pest attacks. Recently, sRNAs-mediated regulations have also been extensively investigated in horticultural plants, with many novel mechanisms unveiled, which display far more mechanistic complexity and unique regulatory features compared to those studied in model species. Here, we review the recent progress of sRNA research in horticultural plants, with emphasis on mechanistic aspects as well as their relevance to trait regulation. Given that major and pioneered sRNA research has been carried out in the model and other plants, we also discuss ongoing sRNA research on these plants. Because miRNAs and phased siRNAs (phasiRNAs) are the most studied sRNA regulators, this review focuses on their biogenesis, conservation, function, and targeted genes and traits as well as the mechanistic relation between them, aiming at providing readers comprehensive information instrumental for future sRNA research in horticulture crops.

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Section: Small Rna Research In Horticultural Plantsmentioning

confidence: 87%

Small RNAs, emerging regulators critical for the development of horticultural traits

et al. 2018

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“…Additionally, the miR-139 in bovine MDSCs and C2C12 cells had different target genes which had different seed sites of their miRNAs. Yao, Tomes, Xu, and Gleave (2016) reported that miR-172 has different effects on the development and growth of Arabidopsis and apple and tomato fruits, thus suggesting that the same miRNA can perform different functions in different species. SP1, BMP4, HMGA1-Id3, and MYF6 are proteins closely related to cell proliferation or differentiation (Brocher, Vogel, & Hock, 2010;Guo, Degnin, Fiddler, Stauffer, & Thayer, 2003;Ju, Yang, Sheng, & Qi, 2016) that also represent targets of miRNA regulation.…”

Section: Discussionmentioning

confidence: 99%

MiR‐139 promotes differentiation of bovine skeletal muscle‐derived satellite cells by regulating DHFR gene expression

Zhou

Zhang

et al. 2018

Journal Cellular Physiology

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MicroRNAs play an important regulatory role in the proliferation and differentiation of skeletal muscle-derived satellite cells (MDSCs). In particular, miR-139 can inhibit tumor cell proliferation and invasion, and its expression is down-regulated during C2C12 myoblast differentiation. The aim of this study was thus to examine the effect and potential mechanism of miR-139 in bovine MDSCs. The expression of miR-139 was found to be significantly increased during bovine MDSC differentiation by stem-loop reverse transcription-polymerase chain reaction amplification. Statistical analysis of the myotube fusion rate was done through immunofluorescence detection of desmin, and western blotting was used to measure the change in protein expression of the muscle differentiation marker genes MYOG and MYH3. The results showed that the miR-139 mimic could enhance the differentiation of bovine MDSCs, whereas the inhibitor had the opposite effect. By using the dual-luciferase reporter system, miR-139 was found to target the 3'-untranslated region of the dihydrofolate reductase (DHFR) gene and regulate its expression. In addition, the expression of miR-139 was found to be regulated by its host gene phosphodiesterase 2A (PDE2A) via inhibition of the latter by CRISPR interference (CRISPRi). Overall, our findings indicate that miR-139 plays an important role in regulating the differentiation of bovine MDSCs.

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“…The AP2 family belongs to class A genes of floral organ identities. Transgenic plants expressing A. thaliana wild type AP2 and miR172 resistant AP2 genes did not show any phenotype due to regulation by the endogenous miR172, rather the overexpression of a miR172-resistant form of AP2 cDNA showed floral patterning defects, indicating the loss of floral organ determinancy [79]. Other AP2-like genes, such as Target of Eat1 (TOE1), TOE2 and TOE3 in A. Thaliana, or Indeterminate Spikelet1 and Gloy15 in Z. Mays, are also under the regulation of miR172.…”

Section: Flowering Time Regulation and Organ Developmentmentioning

confidence: 95%

Salient Genetic Notes on Small-RNAs and their Applications in Agricultural Biotechnology

Amiteye

2020

JABB

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Small-RNAs are 20 to 27 nucleotides long non-protein-coding RNAs that act on either DNA or RNA to effect the regulation of gene expression. Small-RNAs are key in genetic and epigenetic regulation of diverse biological processes and pathways in response to biotic and abiotic environmental stresses. The gene regulatory functions of small-RNA molecules enhance healthy plant growth and normal development by controlling biological processes such as flowering programming, fruit development, disease and pests resistance. Small-RNAs comprise mainly microRNA and small interfering RNA species. MicroRNAs have been proven to primarily engage in posttranscriptional gene regulation while small interfering RNA have been implicated mainly in transcriptional gene regulation. This review covers the recent advancements in small-RNA research in plants, with emphasis on particularly microRNAs and small interfering RNA biogenesis, biological functions and their relevance in the regulation of traits of agronomic importance in plants. Also discussed extensively is the potential biotechnological applications of these small-RNAs for crop improvement.

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How microRNA172 affects fruit growth in different species is dependent on fruit type

Cited by 43 publications

References 20 publications

Small RNAs, emerging regulators critical for the development of horticultural traits

Small RNAs, emerging regulators critical for the development of horticultural traits

MiR‐139 promotes differentiation of bovine skeletal muscle‐derived satellite cells by regulating DHFR gene expression

Salient Genetic Notes on Small-RNAs and their Applications in Agricultural Biotechnology

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