How Microneedles Can Change Cutaneous Drug Delivery—Small Needles Make a Big Difference

Lev‐Tov, Hadar

doi:10.1001/jamadermatol.2017.1039

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…“Sweating” microneedles are structurally similar to soluble ones and contain the active ingredient at a higher concentration. The active pharmaceutical ingredient (API) is released after a hydrogel is formed by liquid from the intercellular space permeating into the needle [ 8 ].…”

Section: Resultsmentioning

confidence: 99%

Prospects of a Transdermal Dosage Form (Microneedles) and Justification of the Active Substance Selection for Development of a New Medicine

et al. 2022

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Prospects for the development of a transdermal dosage form (DF) based on microneedles were considered. Methods for obtaining such systems, the application areas, and data from the pharmaceutical market were examined. A wide sample of INNs that are used to reduce pain in osteoarthritis patients was formed based on clinical guidelines. The market capacity, sales by Anatomical Therapeutic Chemical (ATC-2) groups, and sales depending on the DF were discussed. Criteria for the choice of active ingredients with market potential were defined. An analysis of a short list revealed that meloxicam has sufficient market potential to create a microneedle DF. A forecast of meloxicam consumption based on time series models indicated stable sales-growth dynamics and a potential market size of 4.6 billion Russian rubles by 2030. Results of the study indicated good market prospects and justification of pharmaceutical development of a new transdermal DF including meloxicam microneedles as the active ingredient.

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Section: Resultsmentioning

confidence: 99%

Prospects of a Transdermal Dosage Form (Microneedles) and Justification of the Active Substance Selection for Development of a New Medicine

et al. 2022

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“…However, the rigid design and stiffness mismatch may induce negative effects such as tissue damage, inflammation, and rejection. Flexible, stretchable, and biodegradable polymeric materials, such as synthetic polymers, hydrogels, and bioderived materials, have been explored in both in vitro and in vivo studies to overcome these challenges (12)(13)(14)(15)(16)(17)(18). Polymer microneedles (MNs) made from biocompatible and biodegradable materials like hyaluronic acid (HA) and polyvinyl alcohol (PVA) provide a minimally invasive means of transdermal drug delivery and light transmission to the deeper layers of the skin (19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds

Xue,

Chou,

et al. 2023

Preprint

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Light therapy is an effective approach for the treatment of a variety of challenging dermatological conditions. In contrast to existing methods involving high doses and large areas of illumination, alternative strategies based on wearable designs that utilize a low light dose over an extended period provide a precise and convenient treatment. In this study, we present a battery-free, skin-integrated optoelectronic patch that incorporates a coil-powered circuit, an array of microscale violet and red light emitting diodes (LEDs), and polymer microneedles (MNs) loaded with 5-aminolevulinic acid (5-ALA). This polymer MNs, based on the biodegradable composite materials of polyvinyl alcohol (PVA) and hyaluronic acid (HA), serves as light waveguides for optical access and a medium for drug release into deeper skin layers. Unlike conventional clinical photomedical appliances with a rigid and fixed light source, this flexible design allows for a conformable light source that can be applied directly to the skin. In animal models with bacterial-infected wounds, the experimental group with the combination treatment of metronomic photodynamic and light therapies reduced 2.48 log10CFU mL−1in bactericidal level compared to the control group, indicating an effective anti-infective response. Furthermore, post-treatment analysis revealed the activation of proregenerative genes in monocyte and macrophage cell populations, suggesting enhanced tissue regeneration, neovascularization, and dermal recovery. Overall, this optoelectronic patch design broadens the scope for targeting deep skin lesions, and provides an alternative with the functionality of standard clinical light therapy methods.

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5‐Aminolevulinic Acid‐Loaded Hyaluronic Acid Dissolving Microneedles for Effective Photodynamic Therapy of Superficial Tumors with Enhanced Long‐Term Stability

Zhu

Dong

et al. 2019

Adv Healthcare Materials

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Abstract5‐Aminolevulinic acid (5‐ALA) is one of the most widely used prodrug in clinical photodynamic therapy of dermatological diseases and cancers; yet, its clinical application is still limited by the shallow skin penetration and unsatisfied stability in any existed formulations. Here, 5‐ALA‐loaded hyaluronic acid dissolving microneedles (5‐ALA@HAMNs) are prepared for photodynamic therapy of superficial tumors. The HAMNs can not only assist the loaded 5‐ALA to effectively penetrate the stratum corneum but also provide 5‐ALA with an acidic and oxygen‐free environment to reduce the dimerization of 5‐ALA molecules via Schiff‐base bonds and formation of inactive pyrazine derivatives, thus maintaining its chemical structure and biological activity. The chemical stability of 5‐ALA in HAMNs is confirmed by UV–vis spectra and mass spectra measurements. The 5‐ALA@HAMNs display remarkable tumor elimination both in vitro and in vivo, even after storage at room temperature for nine months, making it a highly potential device for effective delivery of 5‐ALA in cancer photodynamic therapy.

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How Microneedles Can Change Cutaneous Drug Delivery—Small Needles Make a Big Difference

Cited by 7 publications

References 12 publications

Prospects of a Transdermal Dosage Form (Microneedles) and Justification of the Active Substance Selection for Development of a New Medicine

Prospects of a Transdermal Dosage Form (Microneedles) and Justification of the Active Substance Selection for Development of a New Medicine

Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds

5‐Aminolevulinic Acid‐Loaded Hyaluronic Acid Dissolving Microneedles for Effective Photodynamic Therapy of Superficial Tumors with Enhanced Long‐Term Stability

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