How Many Visual Fields Are Required to Precisely Predict Future Test Results in Glaucoma Patients When Using Different Trend Analyses?

Taketani, Yuji; Murata, Hiroshi; Fujino, Yuri; Mayama, Chihiro; Asaoka, Ryo

doi:10.1167/iovs.14-16341

Cited by 47 publications

(66 citation statements)

References 32 publications

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“…Reliable VFs were identified and eyes with at least eight reliable VFs were investigated, excluding the first VF measurement. We chose a minimum of eight VFs because it has recently been reported that this number is needed to precisely analyze VF progression2930313233. Eyes that experienced any surgical procedure, including trabeculectomy and cataract surgery, during or prior to this VF series period were excluded.…”

Section: Methodsmentioning

confidence: 99%

The usefulness of CorvisST Tonometry and the Ocular Response Analyzer to assess the progression of glaucoma

Hirasawa

Murata

Nakakura³

et al. 2017

Sci Rep

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Glaucoma is the second leading cause of blindness worldwide, affecting approximately 60 million peoples 1 . The disease causes irreversible visual field (VF) damage so it is very important to predict its progression and make appropriate interventions as soon as possible. The principal target of glaucoma treatments is to reduce and control intraocular pressure (IOP), which has been shown to reduce VF progression by numerous clinical trials and research studies 2-10 . Tonometry measurements of IOP can be greatly influenced by structural properties of the eye; in particular, IOP measured with Goldmann applanation tonometry (GAT) has been shown to be affected by central corneal thickness (CCT) [11][12][13][14][15][16][17][18][19][20][21][22][23] . Thus, CCT should be considered when interpreting GAT-measured IOP and making clinical decisions. Furthermore, studies have suggested that CCT is associated with the progression of glaucoma 4,24 . Other biomechanical properties of the cornea have also been shown to affect the progression of glaucoma. In particular, corneal hysteresis (CH) and corneal resistance factor (CRF), measured with the Ocular Response Analyzer (ORA, Reichert Ophthalmic Instruments, Depew, NY, USA), have been reported to impinge on progression 25,26 .The Corneal Visualization Scheimpflug Technology instrument (Corvis ST tonometry: CST; Oculus, Wetzlar, Germany) is a new device, integrated with an ultra-high-speed Scheimpflug camera, to quantitatively measure biomechanical properties of the cornea during the application of a rapid air-puff 27 . As a result, very detailed corneal movement during the air puff application can be observed, such as velocity of corneal deformation at the first and second applanations and the maximum depth of corneal deformation (Fig. 1). Although CST and ORA both measure the biomechanical properties of the cornea, their mechanisms are completely different, and the relationship between CST-measured corneal parameters and the progression of glaucomatous VF damage

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Section: Methodsmentioning

confidence: 99%

The usefulness of CorvisST Tonometry and the Ocular Response Analyzer to assess the progression of glaucoma

Hirasawa

Murata

Nakakura³

et al. 2017

Sci Rep

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“…Thirteen eyes of 10 patients who had undergone cataract surgery before the baseline VF were included. We chose a minimum of 10 VFs because it has recently been reported that this volume is needed to precisely analyse VF progression 8. Systemic complications of hypertension (HT), migraine, family history of glaucoma (FH; second-degree blood relative) and smoking status were collected from medical records; all patients who had a note (positive or negative) on all these variables were included in the study.…”

Section: Methodsmentioning

confidence: 99%

Effects of ocular and systemic factors on the progression of glaucomatous visual field damage in various sectors

et al. 2016

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“…Furthermore, the method appears not to be significantly affected by the level of IOP or progression rate. However, despite a significant reduction in prediction error, the magnitude of this improvement is small relative to previous novel regression models that use only VF data345678910. One of the possible reasons for such a small improvement is that IOP fluctuates in the short and long term21 and measuring IOP at the clinic in approximately three month intervals is too infrequent to observe the true trend in IOP.…”

Section: Discussionmentioning

confidence: 92%

“…This is likely because VF progression is related to IOP level as suggested by numerous previous studies34. Various methods have been proposed to measure VF progression in glaucoma patients3479111213143536, however, simple time trend analysis remains the standard in clinical settings. Hence we compared the prediction performance of the IOP integrated trend analysis against the standard approach.…”

Section: Discussionmentioning

confidence: 99%

“…Future VF deterioration is usually predicted by applying ordinary least squares linear regression (OLSLR) to global VF indices such as mean deviation (MD), as in the Guided Progression Analysis™ (GPA) software on the Humphrey Field Analyzer (HFA, Carl Zeiss Meditec AG, Dublin, CA, USA). We have reported several alternative approaches to improve the prediction accuracy of VF progression, such as robust regression3, least absolute shrinkage and selection operator (Lasso) regression4, cluster-wise regression56, and also variational Bayesian linear regression7. In addition, many other successful efforts have been reported from other researchers891011121314, nonetheless ordinary OLSLR is still very frequently used at the clinical setting.…”

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A novel method to predict visual field progression more accurately, using intraocular pressure measurements in glaucoma patients

Asaoka¹,

Fujino²,

Murata³

et al. 2016

Sci Rep

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Visual field (VF) data were retrospectively obtained from 491 eyes in 317 patients with open angle glaucoma who had undergone ten VF tests (Humphrey Field Analyzer, 24-2, SITA standard). First, mean of total deviation values (mTD) in the tenth VF was predicted using standard linear regression of the first five VFs (VF1-5) through to using all nine preceding VFs (VF1-9). Then an ‘intraocular pressure (IOP)-integrated VF trend analysis’ was carried out by simply using time multiplied by IOP as the independent term in the linear regression model. Prediction errors (absolute prediction error or root mean squared error: RMSE) for predicting mTD and also point wise TD values of the tenth VF were obtained from both approaches. The mTD absolute prediction errors associated with the IOP-integrated VF trend analysis were significantly smaller than those from the standard trend analysis when VF1-6 through to VF1-8 were used (p < 0.05). The point wise RMSEs from the IOP-integrated trend analysis were significantly smaller than those from the standard trend analysis when VF1-5 through to VF1-9 were used (p < 0.05). This was especially the case when IOP was measured more frequently. Thus a significantly more accurate prediction of VF progression is possible using a simple trend analysis that incorporates IOP measurements.

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How Many Visual Fields Are Required to Precisely Predict Future Test Results in Glaucoma Patients When Using Different Trend Analyses?

Abstract: Approximately 10 VFs, are needed to achieve an accurate prediction of PW VF sensitivity and mean sensitivity. Prediction error of PW VF sensitivity can be significantly minimized using the M-estimator robust regression model compared with conventional OLSLR.

Cited by 47 publications

References 32 publications

The usefulness of CorvisST Tonometry and the Ocular Response Analyzer to assess the progression of glaucoma

The usefulness of CorvisST Tonometry and the Ocular Response Analyzer to assess the progression of glaucoma

Effects of ocular and systemic factors on the progression of glaucomatous visual field damage in various sectors

A novel method to predict visual field progression more accurately, using intraocular pressure measurements in glaucoma patients

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