How many people with heart failure are appropriate for biventricular resynchronization?

Farwell, David; Patel, Nik; Hall, Alistair S.; Ralph, Sue; Sulke, A. N.

doi:10.1053/euhj.1999.1985

Cited by 198 publications

(109 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These data are comparable to multiple similar studies [1,3,5,6]. Results show that out of the two parameters, SPWMD is the more accurate and more reliable parameter to assess mechanical dyssynchrony.…”

Section: Discussionsupporting

confidence: 79%

See 1 more Smart Citation

Echocardiographic evaluation of mechanical dyssynchrony in heart failure patients with reduced ejection fraction

Gyalai

Jeremiás

Baricz

et al. 2016

THC

View full text Add to dashboard Cite

Abstract. The aim of this study is to observe the differences between mechanical and electrical dyssynchrony in patients with impaired systolic ventricular function and symptomatic heart failure and to highlight the importance of mechanical dyssynchrony besides electrical dyssynchrony in clinical guidelines and clinical practice. Fifty-eight patients with heart failure, who are with the New York Heart Association (NYHA) functional class II-IV and left ventricular ejection fraction (LVEF) under 35%, were enrolled. Patients were divided into two groups, according to the duration of QRS complex (> 120 ms and 120 ms respectively). Echocardiographic parameters of interventricular (interventricular mechanical delay -IMD) and intraventricular (septal-to-posterior wall motion delay -SPWMD) dyssynchrony were measured in both groups. Results indicate that the duration of the QRS complex (i.e. electrical dyssynchrony) is not a fully reliable indicator of ventricular dyssynchrony; therefore ecocardiographic evaluation of mechanical dyssynchrony should also be recommended for better selection of candidates for cardiac resynchronization therapy (CRT).

show abstract

Section: Discussionsupporting

confidence: 79%

“…Multiple studies have proven the existence of statistically significant correlation between the presence of ventricular (mechanical) dyssynchrony and the prolonged duration of QRS complex (electrical dyssynchrony) [1,3].…”

Section: Introductionmentioning

confidence: 99%

Echocardiographic evaluation of mechanical dyssynchrony in heart failure patients with reduced ejection fraction

Gyalai

Jeremiás

Baricz

et al. 2016

THC

View full text Add to dashboard Cite

show abstract

“…Treatment of HF in order to reduce its morbidity and mortality still remains one of the major challenges in health care practice. In approximately 30% of systolic HF patients, the disease affects the conduction system and leads to delayed electrical activation of the lateral part of the left ventricle (LV) [1]. Such intraventricular conduction delay, conventionally defined as electrocardiographic (ECG) QRS complex duration > 120 ms, is known to be associated with adverse LV remodeling, clinical worsening and increased mortality [2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of beta-blockers on left ventricular dyssynchrony and reverse remodeling in idiopathic dilated cardiomyopathy: A randomized trial of carvedilol and metoprolol

et al. 2014

View full text Add to dashboard Cite

(D interventricular delay at 6 months, 11 ± 8 ms to 6 ± 7 ms, p = 0.03). However, improvement in intraventricular dyssynchrony was similar in the two groups (D intraventricular delay, 9 ± 7 ms to 9 ± 6 ms, p = 0.91). Improvements in LV mechanical dyssynchrony and reverse remodeling achieved with both drugs were accompanied by reduction in NT-proBNP levels in both carvedilol and metoprolol groups (1614 ± 685 pg/mL to 654 ± ± 488 pg/mL and 1686 ± 730 pg/mL to 583 ± 396 pg/mL, respectively, p < 0.001 for both). Conclusions: Although reduction in LVEDV and increase in LVEF was higher with carvedilol, improvement in intraventricular dyssynchrony was similar in carvedilol and metoprolol groups. (Cardiol J 2014; 21, 4: 434-441)

show abstract

“…Objectives: Cardiac resynchronisation therapy (CRT) has proven its effectiveness in patients with symptomatic heart failure [1,2]. Although rewarding, the procedure of biventricular pacemaker implantation is challenging and subsequently fails in 8% -11% of patients.…”

Section: Introductionmentioning

confidence: 99%

Surgical Results of Left Ventricular Lead Implantation for Cardiac Resynchronization Therapy

Gür¹,

Gürkan²,

Gür³

et al. 2013

WJCS

View full text Add to dashboard Cite

Objectives: Cardiac resynchronisation therapy (CRT) has proven its effectiveness in patients with symptomatic heart failure [1,2]. Although rewarding, the procedure of biventricular pacemaker implantation is challenging and subsequently fails in 8% -11% of patients. In patients whose left ventricular (LV) electrode cannot be placed transvenously, surgical implantation of an epicardial electrode can be achieved. Methods: Seventeen patients (14 male, 3 female), among whom LV electrode was failed to be placed transvenously, were included into our study. The epicardial LV electrodes were implanted through anterior mini thoracotomy. The patients were followed up for approximate six months and complications, ejection fraction (EF), New York Heart Association (NYHA) class, QRS durations as well as pacing parameters were recorded. Results: Mean age of the patients was 64.4 ± 7.01 (54 -79) years. Preoperative mean EF of the patients was 26.1% ± 3.7%. The LV electrode was placed at the optimal place on the lateral LV wall through left sided mini thoracotomy. The mean duration of the operation was 26.76  8.12 minutes and the mean hospital stay was 2.05  0.42 days. There were no intraoperative or postoperative complications. Only 1 patient had LV electrode displaced on the 3rd postoperative month and the patient was reoperated successfully. The EF on the 6th postoperative month was 29.4% ± 3.81% and NYHA class was 2.58 ± 0.5. The etiology of heart failure had no influence on outcome. Conclusions: Surgical implantation of LV lead is associated with low complication rates and excellent follow-up results without exposure to radiation. Thus epicardial leads can be proposed as equal alternative to transvenous leads.

show abstract

How many people with heart failure are appropriate for biventricular resynchronization?

Abstract: Using our criteria, approximately 10% of an unselected group of heart failure admitted to a typical U.K. district general hospital over a calendar year would be appropriate for biventricular pacing. This represents a large number of patients who might derive benefit from this new therapy.

Cited by 198 publications

References 12 publications

Echocardiographic evaluation of mechanical dyssynchrony in heart failure patients with reduced ejection fraction

Echocardiographic evaluation of mechanical dyssynchrony in heart failure patients with reduced ejection fraction

Evaluation of beta-blockers on left ventricular dyssynchrony and reverse remodeling in idiopathic dilated cardiomyopathy: A randomized trial of carvedilol and metoprolol

Surgical Results of Left Ventricular Lead Implantation for Cardiac Resynchronization Therapy

Contact Info

Product

Resources

About