How many cadherins do human endothelial cells express?

Colás-Algora, Natalia; Millán, Jaime

doi:10.1007/s00018-018-2991-9

Cited by 34 publications

(33 citation statements)

References 141 publications

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“…Cadherins are transmembrane glycoproteins responsible for cell-cell adhesion and maintenance of normal tissue architecture. In addition, cadherins have been found not only between the tumor cells but also in body fluids (mainly in blood) [ 1 , 2 , 3 ]. The classical cadherins, among which there are many subgroups, are a class of adhesion molecules that interact with catenins through the cytoplasmic domain [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, cadherins have been found not only between the tumor cells but also in body fluids (mainly in blood) [ 1 , 2 , 3 ]. The classical cadherins, among which there are many subgroups, are a class of adhesion molecules that interact with catenins through the cytoplasmic domain [ 1 ]. The classical cadherins are epithelial-cadherin, placental-cadherin and neural-cadherin (E-, P- and N-cadherin, respectively).…”

Section: Introductionmentioning

confidence: 99%

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Role of Cadherins in Cancer—A Review

Kaszak

Witkowska-Piłaszewicz

Niewiadomska

et al. 2020

IJMS

231

132

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Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis. Cadherins are inseparably connected with catenins, forming cadherin-catenin complexes, which are crucial for cell-to-cell adherence. Any dysfunction or destabilization of cadherin-catenin complex may result in tumor progression. Epithelial mesenchymal transition (EMT) is a mechanism in which epithelial cadherin (E-cadherin) expression is lost during tumor progression. However, during tumorigenesis, many processes take place, and downregulation of E-cadherin, nuclear β-catenin and p120 catenin (p120) signaling are among the most critical. Additional signaling pathways, such as Receptor tyrosine kinase (RTK), Rho GTPases, phosphoinositide 3-kinase (PI3K) and Hippo affect cadherin cell-cell adhesion and also contribute to tumor progression and metastasis. Many signaling pathways may be activated during tumorigenesis; thus, cadherin-targeting drugs seem to limit the progression of malignant tumor. This review discusses the role of cadherins in selected signaling mechanisms involved in tumor growth. The clinical importance of cadherin will be discussed in cases of human and animal cancers.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of Cadherins in Cancer—A Review

Kaszak

Witkowska-Piłaszewicz

Niewiadomska

et al. 2020

IJMS

231

132

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“…This effect may be needed because increased force associated with cell-to-cell contact would otherwise over-activate Piezo1 channels and cause too much local cytoplasmic Ca 2+ elevation. Appropriate Ca 2+ elevation is important for numerous proteins, including CD31 because of its suggested calpain-dependent cleavage 30 and VE-cadherin because of its inherent Ca 2+ sensitivity 14, 15 . The importance of calpain, a Ca 2+ -activated protease, as a downstream mediator of Piezo1 effects, regulator of cytoskeletal anchorage complexes and component of the endothelial flow sensing machinery has been proposed 17,[31][32][33] .…”

Section: Discussionmentioning

confidence: 99%

“…It is often used as an endothelial cell marker but is expressed and functional also in leukocytes and platelets 12 . VE-cadherin belongs to a large family of transmembrane Ca 2+ -dependent adhesion molecules 14,15 . It also has an extracellular domain that mediates homotypic interactions and an intracellular regulatory domain, which in this case binds -or -catenin to promote cytoskeletal interaction 14 .…”

Section: Introductionmentioning

confidence: 99%

Cell adhesion molecule interaction with Piezo1 channels is a mechanism for sub cellular regulation of mechanical sensitivity

Chuntharpursat‐Bon

Povstyan

Ludlow

et al. 2019

Preprint

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The discovery of Piezo1 channels as force sensors with roles in the endothelial response to fluid flow has appeared contradictory to earlier work suggesting mediation by a triad of cell adhesion molecules (CD31 and VE-cadherin) and vascular endothelial growth factor receptor 2 (VEGFR2). Here we propose an explanation. Stimulated emission depletion microscopy revealed physical proximity between Piezo1 and CD31 primarily at cell junctions. Förster resonance energy transfer measured by fluorescence lifetime imaging showed that the proteins approached to less than 10 nm. Substitution of a tyrosine residue at the distal Cterminus of CD31 prevented the interaction, suggesting intracellular association. The extracellular N-terminus also interacted, but exclusively at cell junctions. There was proximity between Piezo1 and VE-cadherin but not VEGFR2. Interaction with VE-cadherin was flowdependent, consistent with additional recruitment after flow-sensing. CD31 suppressed mechanical sensitivity of Piezo1 channels and interacted with N-terminal Piezo1 propeller arms implicated in force sensing. The data suggest partnership between Piezo1 and adhesion molecules for sub cellular tuning of force response.

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“…Destabilization of this barrier leads to leakage of plasma constituents from the vessels which may result in the development of inflammation and tissue edema [ 1 ]. Normal functioning of the endothelium is highly reliant on calcium-dependent adhesion membrane proteins called cadherins [ 2 ]. Endothelial cells generally express two types of these proteins: neural cadherin (N-cadherin), which is scattered around the cell surface and forms junctions between the basal membrane of the endothelium and underlying pericytes [ 2 ], and vascular endothelial cadherin (VE-cadherin), which is mostly responsible for the mediation of complex cell-cell interactions [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

How Does Endothelial Permeability Affect the Development of Juvenile Idiopathic Arthritis? Vascular Endothelial Cadherin as a Promising New Tool Helpful in the Diagnostic Process

Orczyk

Smolewska

2020

Disease Markers

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Introduction. Vascular endothelial cadherin (VE-cadherin) is a calcium-dependent protein essential for stabilization of the adherens junctions of the endothelial cells. Through vasculogenic mimicry, VE-cadherin may influence angiogenesis in synovial fibroblast-like cells. The soluble extracellular domain of VE-cadherin may be considered an indicator of endothelial dysfunction. Its potential as a diagnostic biomarker in rheumatic diseases, including juvenile idiopathic arthritis (JIA), needs to be investigated. Materials and Methods. The study group included 80 patients diagnosed with JIA. In 53 individuals, blood samples were obtained twice with an average interval of 102.4 ± 4.6 days. Results from the study group were compared to 29 age- and sex-matched healthy children. Results. Serum levels of VE-cadherin were significantly higher in JIA patients than in healthy controls. In such comparison, VE-cadherin had 87.5% sensitivity and 69.0% specificity for the cutoff level 4.36 ng/ml (Youden index 0.56, area under the curve 0.724). VE-cadherin concentrations negatively correlated with the disease activity score. However, such finding may be a false result because of the downregulation of VE-cadherin induced by glucocorticosteroids. Conclusions. VE-cadherin may become a promising diagnostic biomarker of early stages of JIA. Its predictive significance may be decreased by utilization of glucocorticosteroids. A multicentre study including patients with other arthritides is recommended for further evaluation of this protein.

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How many cadherins do human endothelial cells express?

Cited by 34 publications

References 141 publications

Role of Cadherins in Cancer—A Review

Role of Cadherins in Cancer—A Review

Cell adhesion molecule interaction with Piezo1 channels is a mechanism for sub cellular regulation of mechanical sensitivity

How Does Endothelial Permeability Affect the Development of Juvenile Idiopathic Arthritis? Vascular Endothelial Cadherin as a Promising New Tool Helpful in the Diagnostic Process

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