How Low Should You Go? The Limbo of Glycemic Control in Intensive Care Units

Faust, Andrew C.; Attridge, Rebecca L.; Ryan, Laurajo

doi:10.4037/ccn2011188

Cited by 6 publications

(6 citation statements)

References 57 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The complete absence of glucose is not a physiologically relevant stress; however, hypoglycemia is a relatively common complication associated with management of diabetes as well as the treatment of acute hyperglycemia that occurs after surgery and in response to acute stress (49,50). Clinically, mild hypoglycemia, which may or may not be symptomatic, is defined as a plasma glucose concentration of Ͻ3.9 mM, whereas severe hypoglycemia is typically considered as Ͻ2.8 mM accompanied by dysfunction of the central nervous system (49).…”

Section: Discussionmentioning

confidence: 99%

Glucose Deprivation-induced Increase in Protein O-GlcNAcylation in Cardiomyocytes Is Calcium-dependent

Zou

Zhu-Mauldin

Marchase

et al. 2012

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: Levels of cellular protein O-GlcNAc modification increase in response to stress, but mechanism not understood. Results: Glucose deprivation and heat shock-induced increase in O-GlcNAcylation are attenuated by CaMKII inhibition. Conclusion: CaMKII activation plays a key role in regulating the stress-induced increase in O-GlcNAc. Significance: Understanding the regulation of O-GlcNAcylation is critical in determining its role in cellular stress responses.

show abstract

Section: Discussionmentioning

confidence: 99%

Glucose Deprivation-induced Increase in Protein O-GlcNAcylation in Cardiomyocytes Is Calcium-dependent

Zou

Zhu-Mauldin

Marchase

et al. 2012

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…The incidence of hyperglycemia in the critically ill population is much higher than in the general medical population. At least 50% of Intensive Care Unit (ICU) patients experience hyperglycemia (Faust, Attridge, & Ryan, 2011). These elevated blood glucose concentrations are known to be associated with adverse outcomes (Faust et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Another factor contributing to poor outcomes in the diabetic patient is wide shifts in blood glucose, as this results in a higher mortality rate than patients without these highly varied blood glucose levels (Faust et al, 2011). In 2017, both the ADA and the American Association of Clinical Endocrinologists (AACE) issued consensus guidelines for the blood glucose control of critically ill patients.…”

Section: Hyperglycemia In the Critical Care Environmentmentioning

confidence: 99%

Diabetes Knowledge of Critical Care Nurses: A Quality Improvement Project

Huley¹

2019

Preprint

View full text Add to dashboard Cite

Diabetes mellitus continues to become more prevalent in the United States, with approximately 1.5 million new cases diagnosed each year (ADA, 2018). Nurses play a key role in providing education to diabetic patients on the management of this disease. This encompasses a multitude of topics such as diabetic medications, treatments, and lifestyle choices that ultimately may aid in decreased morbidity and mortality otherwise associated with the disease and its co-morbidities. However, nurses’ own perceived diabetes knowledge has been found to be overestimated when compared to actual nursing knowledge (Alotaibi, Ghlizadeh, Al-Ganmi&Perry, 2017; Wakefield&Wilson, 2014). Research also illustrates that the actual knowledge of diabetes care is suboptimal, and educational programs specifically tailored to diabetes management knowledge result in an improvement from pre-test scores with subsequent retention of the materials presented (Moattari, Moosavinasab, Dabaghmanesh,&SarifSanaiey, 2014; Sweeney, Kenny and Schubert, 2013). The following literature review appraises current practice in diabetes management and evaluates literature regarding actual knowledge of nurses caring for inpatient diabetics. The purpose of this quality improvement project was to determine whether the implementation of a diabetic education program improves nurses’ knowledge in the medical management, treatment, and care of the adult critical care patient with hyperglycemia. Results demonstrated variability in baseline knowledge and overall significant improvement in scores which validated the need for this program and may indicate a need to focus future educational programs on the care of the patient with diabetes.

show abstract

“…Faust et al 6 enfatizaram as nuances dos escritos e pequisas sobre controle glicêmico na terapia intensiva e propuseram uma recomendação para tal controle. Relataram que a prática da insulina infundida por via subcutânea era inapropriada, pois os valores de glicose sanguínea ficavam acima de 180 mg/dL e isso estava associado a resultados negativos.…”

Section: Hipoglicemia Associada à Insulinoterapia Endovenosaunclassified

“…O alvo da glicemia ajustada para valores maiores poderia reduzir o número de episódios de hipoglicemia severa, com diminuição da mortalidade. Ao analisar a relação da hipoglicemia leve ou moderada sob a mortalidade de pacientes graves, relataram que dos 4.946 pacientes internados na UTI, 1.109 tinham pelo menos um episódio de hipoglicemia (<81 mg/dL) 6 . Verificou-se que em pacientes criticamentes enfermos existe uma associação entre a hipoglicemia e a mortalidade, e quanto maior grau de hipoglicemia maior o risco de morte 6 .…”

Section: Hipoglicemia Associada à Insulinoterapia Endovenosaunclassified

Fatores de risco para hipoglicemia em pacientes que usam infusão contínua de insulina endovenosa na unidade de terapia intensiva

Paixão

Silva

Doerzapff³

et al. 2014

ABCS Health Sci.

View full text Add to dashboard Cite

Trata-se de revisão descritiva dos fatores de risco para hipoglicemia em pacientes com infusão contínua de insulina na terapia intensiva. Buscaram-se publicações entre 2006 e 2012, em livros e artigos de bases indexadas em bibliotecas virtuais. Selecionadas oito publicações ordenadas em categorias que tratavam da hipoglicemia, terapia nutricional e protocolos glicêmicos associados à insulinoterapia venosa. Conclui-se que há fatores de risco comuns à equipe multiprofissional e o conhecimento desses fatores permitirá a segurança dos pacientes na utilização dessa terapêutica.

show abstract

How Low Should You Go? The Limbo of Glycemic Control in Intensive Care Units

Cited by 6 publications

References 57 publications

Glucose Deprivation-induced Increase in Protein O-GlcNAcylation in Cardiomyocytes Is Calcium-dependent

Glucose Deprivation-induced Increase in Protein O-GlcNAcylation in Cardiomyocytes Is Calcium-dependent

Diabetes Knowledge of Critical Care Nurses: A Quality Improvement Project

Fatores de risco para hipoglicemia em pacientes que usam infusão contínua de insulina endovenosa na unidade de terapia intensiva

Contact Info

Product

Resources

About