How large pharma impacts biotechnology startup success

Dydiowa, Gina Melchner von; Deventer, Sander van; Couto, Daniela S.

doi:10.1038/s41587-021-00821-x

Cited by 12 publications

(2 citation statements)

References 4 publications

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“…Another reason is the unprecedented penetration of new technologies (AI, cloud computing, gene editing tools) in agricultural and health sectors (Savin et al, 2022 ), which attract new investors. An additional reason for increasing attractiveness of startups in pharmaceutics is the shift of biopharmaceutical drug development from in-house production of large pharma companies to small and mid-sized companies to diversify risky internal R&D programs (Melchner von Dydiowa et al, 2021 ; Murphey, 2019 ). With the rapid advances of new technologies in this sector, large pharma companies appear as investors for initial drug development that boosted funding of biopharmaceutical startups over the past decade.…”

Section: Resultsmentioning

confidence: 99%

Topic-based classification and identification of global trends for startup companies

2022

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To foresee global economic trends, one needs to understand the present startup companies that soon may become new market leaders. In this paper, we explore textual descriptions of more than 250 thousand startups in the Crunchbase database. We analyze the 2009–2019 period by using topic modeling. We propose a novel classification of startup companies free from expert bias that contains 38 topics and quantifies the weight of each of these topics for all the startups. Taking the year of establishment and geographical location of the startups into account, we measure which topics were increasing or decreasing their share over time, and which of them were predominantly present in Europe, North America, or other regions. We find that the share of startups focused on data analytics, social platforms, and financial transfers, and time management has risen, while an opposite trend is observed for mobile gaming, online news, and online social networks as well as legal and professional services. We also identify strong regional differences in topic distribution, suggesting certain concentration of the startups. For example, sustainable agriculture is presented stronger in South America and Africa, while pharmaceutics, in North America and Europe. Furthermore, we explore which pairs of topics tend to co-occur more often together, quantify how multisectoral the startups are, and which startup classes attract more investments. Finally, we compare our classification to the one existing in the Crunchbase database, demonstrating how we improve it.

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Section: Resultsmentioning

confidence: 99%

Topic-based classification and identification of global trends for startup companies

2022

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“…This will also lay the groundwork for collaboration and discourse between the developers of these technologies and the end users. Biotechnology start-up companies are much more likely to succeed when they benefit from strong interactions with the pharmaceutical industry [59] and a similar effect will most likely be found for emerging companies based on microfluidic technologies. It is also worth considering that, although microfluidic technologies are used as a tool in a wide range of fields, it is rare to find as much innovation and enthusiasm either in academic laboratories or in emerging companies as is found in the research and development of organ-on-a-chip technologies.…”

Section: Box 1 the Regulatory Pathway For Microfluidic Technologiesmentioning

confidence: 87%