How is delayed ejaculation defined and treated in North America?

Butcher, Michael; Welliver, Robert C.; Sadowski, Daniel; Botchway, Albert; Köhler, Tobias

doi:10.1111/andr.12041

Cited by 16 publications

(16 citation statements)

References 27 publications

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“…Unfortunately, there is currently no single gold standard for diagnosing DE/AE, as operationalized criteria do not exist [ 3 7 22 ]. Because many organic and psychological factors may be involved in the pathogenesis of DE/AE, a careful clinical history and appropriate physical examination should focus on all related symptoms and signs.…”

Section: Diagnosismentioning

confidence: 99%

“…While some women enjoy the prolonged IELT, others may experience pain, question their own attractiveness, or suspect the partner's infidelity [ 21 ]. Although clinical advances have been made in the diagnosis and treatment of erectile dysfunction, there is a consensus that DE/AE is still a poorly understood disorder, with inconsistent practice patterns seen among practicing physicians [ 22 ]. This article aims to review the pathophysiology of DE/AE, to explore our current understanding of the diagnosis, and to present the treatment options for this condition.…”

Section: Introductionmentioning

confidence: 99%

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Delayed Ejaculation: Pathophysiology, Diagnosis, and Treatment

Abdel‐Hamid

Ali

2018

World J Mens Health

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Delayed ejaculation (DE) is a poorly defined and uncommon form of male sexual dysfunction, characterized by a marked delay in ejaculation or an inability to achieve ejaculation. It is often quite concerning to patients and their partners, and sometimes frustrates couples' attempts to conceive. This article aims to review the pathophysiology of DE and anejaculation (AE), to explore our current understanding of the diagnosis, and to present the treatment options for this condition. Electronic databases were searched from 1966 to October 2017, including PubMed (MEDLINE) and Embase. We combined “delayed ejaculation,” “retarded ejaculation,” “inhibited ejaculation,” or “anejaculation” as Medical Subject Headings (MeSH) terms or keywords with “epidemiology,” “etiology,” “pathophysiology,” “clinical assessment,” “diagnosis,” or “treatment.” Relevant sexual medicine textbooks were searched as well. The literature suggests that the pathophysiology of DE/AE is multifactorial, including both organic and psychosocial factors. Despite the many publications on this condition, the exact pathogenesis is not yet known. There is currently no single gold standard for diagnosing DE/AE, as operationalized criteria do not exist. The history is the key to the diagnosis. Treatment should be cause-specific. There are many approaches to treatment planning, including various psychological interventions, pharmacotherapy, and specific treatments for infertile men. An approved form of drug therapy does not exist. A number of approaches can be employed for infertile men, including the collection of nocturnal emissions, prostatic massage, prostatic urethra catheterization, penile vibratory stimulation, probe electroejaculation, sperm retrieval by aspiration from either the vas deferens or the epididymis, and testicular sperm extraction.

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Section: Diagnosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Delayed Ejaculation: Pathophysiology, Diagnosis, and Treatment

Abdel‐Hamid

Ali

2018

World J Mens Health

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“…A sample of sexual health providers in a recent survey self-reported a 40 % success rate in treatment of DE with medications [30]. The two most common choices for first-line treatment were cabergoline and bupropion.…”

Section: Pharmacologic Agentsmentioning

confidence: 99%

Delayed Ejaculation: Medical and Psychological Treatments and Algorithm

Sadowski

Butcher

Köhler

2015

Curr Sex Health Rep

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Delayed ejaculation (DE) is a challenging disorder to treat. Many clinicians are not comfortable dealing with DE due to a lack of treatment approaches supported by evidence-based medicine. In this review, we discuss the most common treatments and the latest studies that support each DE treatment. The goal of our review is to help clinicians identify and treat patients who present with this disorder. An integrative approach using medications, penile vibratory stimulation, and sexual counseling is important for successful treatment of DE. We propose an algorithm for DE treatment to help guide clinicians. However, an individualized treatment plan should be developed for each unique case due to the multifactorial etiology of DE.

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“…Proposed etiological factors include many medical, psychological and lifestyle factors (2-4). DE is not easy to treat because it is poorly understood (2,5). Treatment should be etiology specific, and may include patient and their partner psychosexual therapy, drug therapy or integrated treatment.…”

Section: Introductionmentioning

confidence: 99%

“…However, no drugs have been approved by regulatory agencies for this indication. In a recent survey to evaluate the current opinion and clinical management of DE by members of the Sexual Medicine Society of North America (SMSNA), cabergoline and bupropion were the most commonly selected first line treatments for DE (5). There is a consensus that DE is still a poorly understood disorder with inconsistent practice patterns seen among members of the SMSNA.…”

Section: Introductionmentioning

confidence: 99%

The drug treatment of delayed ejaculation

Abdel‐Hamid¹,

Elsaied²,

Mostafa³

2016

Transl. Androl. Urol.

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Delayed ejaculation (DE) is an uncommon and a challenging disorder to treat. It is often quite concerning to patients and it can affect psychosocial well-being. Here we reviewed how DE is treated pharmacologically .We also highlighted specific settings where drugs could be introduced to medical practice. Electronic databases were searched from 1966 to February 2016, including PubMed MEDLINE, EMBASE, EBCSO Academic Search Complete, Cochrane Systematic Reviews Database, and Google Scholar using key words; delayed ejaculation, retarded ejaculation, inhibited ejaculation, drugs, treatment, or pharmacology. To achieve the maximum sensitivity of the search strategy and to identify all studies, we combined “delayed ejaculation” as Medical Subject Headings (MeSH) terms or keywords with each of “testosterone” or “cabergoline” or “bupropion” or “amantadine” or “cyproheptadine” or “midodrine” or “imipramine” or “ephedrine” or “pseudoephedrine” or “yohimbine” or “buspirone” or “oxytocin” or “bethanechol” as MeSH terms or keywords. There are a number of drugs to treat patients with DE including: testosterone, cabergoline, bupropion, amantadine, cyproheptadine, midodrine, imipramine, ephedrine, pseudoephedrine, yohimbine, buspirone, oxytocin, and bethanechol. Although there are many pharmacological treatment options, the evidence is still limited to small trials, case series or case reports. Review of literature showed that evidence level 1 (Double blind randomized clinical trial) studies were performed with testosterone, oxytocin, buspirone or bethanechol treatment. It is concluded that successful drug treatment of DE is still in its infancy. The clinicians need to be aware of the pathogenesis of DE and the pharmacological basis underlying the use of different drugs to extend better care for these patients. Various drugs are available to address such problem, however their evidence of efficacy is still limited and their choice needs to be individualized to each specific case.

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How is delayed ejaculation defined and treated in North America?

Cited by 16 publications

References 27 publications

Delayed Ejaculation: Pathophysiology, Diagnosis, and Treatment

Delayed Ejaculation: Pathophysiology, Diagnosis, and Treatment

Delayed Ejaculation: Medical and Psychological Treatments and Algorithm

The drug treatment of delayed ejaculation

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