How Iran responded to expanding need for laboratory services for COVID-19?

Salehi‐Vaziri, Mostafa; Arashkia, Arash; Mostafavi, Ehsan; Jalali, Tahmineh; Pouriayevali, Mohammad Hassan; Fazlalipour, Mehdi; Shoja, Zabihollah; Rohani, Mahdi; Esmaeili, Saber; Fotouhi-Chahooki, F; Baesi, Kazem; Maleki, Ali; Nasab, Seyed Dawood Mousavi; Ahmadi, Zahra; Mohammadi, Tahereh; Azad-nManjiri, Sanam; Nosrati, Mohammad Sadegh Shams; Tavakoli, Mahsa; Fereydouni, Zahra; Khakifirouz, Sahar; Samiee, Siamak Mirab; Biglari, Alireza; Azadmanesh, Kayhan

doi:10.1016/j.hlpt.2021.100506

Cited by 7 publications

(9 citation statements)

References 7 publications

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“…In February 2020, the rst COVID-19 laboratory was established at the Pasteur Institute of Iran when the commercial kits had not been imported to Iran yet. Thus, this institute was authorized to form the COVID-19 laboratory diagnostic committee and direct the national laboratory diagnostic network with the support of the Ministry of Health (15). Thousands of suspected COVID-19 samples were sent daily to the Pasteur Institute of Iran post the rst case recognition in the country on 18th February 2020.…”

Section: Resultsmentioning

confidence: 99%

“…Hence, Pasture Institute of Iran provided the rst diagnostic laboratory for SARS-CoV-2 infection. All the collected COVID-19 suspected samples were sent to this institute and the educated staff and experts put all their effort day and night to handle the tests immediately and thus prevented from any probable crisis (15,16).…”

Section: Covid-19 By Vaccination and Effective Interventions (6-8)mentioning

confidence: 99%

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The Significant Contribution of Pasteur Institute of Iran to COVID-19 Pandemic Control: A Successful Map over the Obstacles

Larijani

Biglari

Sorouri

et al. 2022

Preprint

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Background The present study aims to show the comprehensive effort of Pasteur Institute of Iran and its scientists regarding COVID-19 chaos management, related studies, achievements and vaccine production though there were many imposed challenges. Methods The relevant literature review was done through the associated data from national and international databases, published and under review research articles and also through reports obtained from official meetings with the heads of the related departments. Results The taken strategy adopted by Pasteur Institute of Iran was based on six arms including COVID-19 laboratory network establishment, vaccine research and production, monitoring of SARS-CoV-2 variants, diagnostic tests production, conduction of applied and basic research, and community management and support which eventually utilized appropriate technology for facilitating vaccination as well as the pandemic control at the right time. Conclusion The COVID-19 pandemic which was going to be a real crisis, led to a precise and great performance of Pasteur Institute of Iran owing to the unity of the scientists and the staff. COVID-19 pandemic has been managed by COVID-19 laboratory network set up, approved vaccines in collaboration with Cuba, evaluation and validation system of diagnostic and immunological COVID-19 kits, community Support and careful SARS-CoV-2 Variants Screening. COVID-19 is not over yet and the role of Pasteur Institute of Iran in dealing with this pandemic is still pivotal. There are some other challenges to overcome such as preparation for any COVID-19 probable trend, data management and update, long-term safety and efficacy of the vaccines and providing supplies.

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Section: Resultsmentioning

confidence: 99%

Section: Covid-19 By Vaccination and Effective Interventions (6-8)mentioning

confidence: 99%

The Significant Contribution of Pasteur Institute of Iran to COVID-19 Pandemic Control: A Successful Map over the Obstacles

Larijani

Biglari

Sorouri

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

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“…This action was taken in response to the need to create an agile structure for identifying, monitoring and detecting emerging infectious diseases (Table 1). 5 From its establishment until the COVID-19 pandemic, the team…”

Section: Establishment Of the Covid-19 National Laboratory Network In...mentioning

confidence: 99%

“…Shortly after the news of the detection of a novel coronavirus in China on 31 December 2019, the rapid response team decided on January 18, 2020, to use all available capacities to launch diagnostic tests for the emerging virus (named 2019 novel coronavirus [2019‐nCoV] at that time) as soon as possible. In this regard, the following several actions were taken: (1) optimizing the pan‐coronavirus RT‐PCR test that had been designed in 2015 6 ; (2) designing diagnostic tests based on the published protocols of Corman et al 7 and Hong Kong University 8 ; (3) sending a request for clinical kits and positive control to WHO, Pasteur Institute networks, and EVAg; and (4) ordering available commercial kits in the market including PrimerDesign Ltd., UK (COVID‐19 genesig® Real‐Time PCR assay, detecting RdRp gene) 5 . Subsequently, the first COVID‐19 laboratory started working as the national reference laboratory on January 25, 2020, at the IPI, and the readiness to receive suspected samples was formally announced to the Ministry of Health.…”

Section: Establishment Of the Covid‐19 National Laboratory Network In...mentioning

confidence: 99%

Role of Laboratory in Emerging Infectious Disease Control in Iran, Pasteur Institute of Iran, and national laboratory network

Maleki,

Mostafavi,

Fazlalipour

et al. 2023

Influenza Resp Viruses

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Strengthening surveillance systems is a key aspect of outbreak response and was particularly important during the COVID‐19 pandemic. Respiratory pathogens spread rapidly, and laboratory capacity is key to monitoring the spread. Prior to the pandemic, Iran had established a rapid response team and laboratory network to provide identification, monitoring, and detection of emerging infectious diseases, but did not have the laboratory capacity to respond to COVID‐19. Following the announcement of the COVID‐19 pandemic, the rapid response team diverted all attention to supporting COVID‐19 surveillance. Iran built on the existing national laboratory infrastructure to incorporate SARS‐CoV‐2 surveillance into the response network. Based on existing international protocols, in‐house molecular diagnosis capacity was operationalized, and commercial controls and assays were acquired and validated to national standards. The first COVID‐19 laboratory was operational by January 25, less than 4 weeks before the initial detection of SARS‐CoV‐2 was announced. Assays and support were expanded and rolled out to form the COVID‐19 National Laboratory Network, which consists of 560 multi‐sectoral laboratories covering all provinces of Iran. The national laboratory network supports a wide range of operational capacities, including assay validation and protocol development, quality assurance, respiratory pathogen diagnosis and surveillance, and variant identification and assessment using multiple sequencing platforms. This network has supported the testing of over 55 million samples over the past 36 months using RT‐qPCR and has sequenced approximately 2200 samples across the country, contributing the data to international databases, including GISAID.

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“…Interestingly, the multiplex assay showed that the first, second, and third samples (obtained on September 13, 14, and 15, 2021) were positive for HCoV HKU1/ HCoV OC43. To confirm HKU1/ HCoV OC43 infection, a pan coronavirus RT-PCR assay was employed to amplify about 600 bp of the genome [9]. The PCR products were subsequently sequenced with the amplification primers via the Sanger assay by a 3130 Genetic Analyzer (Thermo Fisher Scientific, USA).…”

Section: Case Reportmentioning

confidence: 99%

Sequential HCoV-HKU1 and SARS-CoV-2 Infections, a Case Report

Maleki

Pouriayevali

Tavakoli

et al. 2022

JoMMID

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In the SARS-CoV-2 pandemic, the seasonal viral respiratory infections had a minimum prevalence due to public health precautions to reduce the risk of getting Coronavirus Disease 19 (COVID-19). There have been reports of COVID-19 coinfection with influenza, respiratory syncytial virus (RSV), and seasonal coronaviruses during the pandemic. Here, we report a case in which the patient had sequential respiratory infections of human coronavirus HKU1 (HCoV-HKU1) and SARS-CoV-2 in a fully vaccinated, healthy person. It should be noted that other seasonal coronaviruses that could cause symptomatic RTIs might be misdiagnosed clinically with COVID-19. Hence, we highly recommend monitoring and follow-up of symptomatic patients with negative SARS-COV-2 RT-PCR results.

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How Iran responded to expanding need for laboratory services for COVID-19?

Cited by 7 publications

References 7 publications

The Significant Contribution of Pasteur Institute of Iran to COVID-19 Pandemic Control: A Successful Map over the Obstacles

The Significant Contribution of Pasteur Institute of Iran to COVID-19 Pandemic Control: A Successful Map over the Obstacles

Role of Laboratory in Emerging Infectious Disease Control in Iran, Pasteur Institute of Iran, and national laboratory network

Sequential HCoV-HKU1 and SARS-CoV-2 Infections, a Case Report

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