How I investigate Eosinophilia

Larsen, Rebecca L.; Savage, Natasha M.

doi:10.1111/ijlh.12955

Cited by 25 publications

(26 citation statements)

References 27 publications

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“…However, at the end of ch14.18/ CHO LTI (d18), a strong increase of neutrophil counts occurred (2.7-, 1.6-, 1.6-, 1.9-and 2.3 fold increase vs. baseline, for cycle 1-5, respectively), indicating a ch14.18/CHOdependent effect on this cell population (Figure 2c and d). In contrast to neutrophils, we observed an increase of eosinophil counts following IL-2 on d8 (3.1-, 6.4-, 6.0-, 6.3-and 6.3 fold increase vs. baseline for cycle 1-5, respectively) that was further elevated during the combinatorial treatment in all cycles resulting on d15 in eosinophilia (threshold 350 cells/ µl) 27,28 in 90% of the treated patients (9.5-, 6.2-, 6.9-, 6.2-and 9.1-fold increases vs. baseline for cycle 1-5, respectively) ( Figure 2e). Trough levels on d1 in cycles 2-5 were about 3-fold increase compared to the baseline.…”

Section: Impact Of Il-2 and Ch1418/cho Treatment On Immune Cell Popumentioning

confidence: 62%

Low CD4⁺/CD25⁺/CD127⁻ regulatory T cell- and high INF-γ levels are associated with improved survival of neuroblastoma patients treated with long-term infusion of ch14.18/CHO combined with interleukin-2

et al. 2019

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Immunotherapy with the anti-GD2 antibody (Ab) ch14.18/CHO in combination with interleukin 2 (IL-2) has improved survival of high-risk neuroblastoma (NB) patients. Here, we report immunotherapy-related effects on circulating NK cells, regulatory T cells (Tregs), granulocytes as well as on Ab-dependent cell-mediated cytotoxicity (ADCC) and cytokines IFN-γ, IL-6, IL-10, IL-18 and CCL2 and their association with progression-free survival (PFS).In a closed single-center program, 53 patients received five cycles of 6 × 106 IU/m2 subcutaneous IL-2 (d1-5; 8–12) combined with long-term infusion (LTI) of 100 mg/m2 ch14.18/CHO (d8-18). Immune cells and cytokines were analyzed by flow cytometry and ADCC by calcein-AM-based cytotoxicity assay.IL-2 administration increased cytotoxic NK cell-, eosinophil- and Treg counts in cycle 1 (2.9-, 3.1- and 20.7-fold, respectively) followed by further increase in subsequent cycles, whereas neutrophil levels were elevated only after the ch14.18/CHO infusion (2.4-fold change). Serum concentrations of IFN-γ, IL-6, IL-10, IL-18 and CCL2 in cycle 1 were increased during the combinatorial therapy (peak levels of 3,656 ± 655 pg/ml, 162 ± 38 pg/ml, 20.91 ± 4.74 pg/ml, 1,584 ± 196 pg/ml and 2,159 ± 252 pg/ml, respectively). Surprisingly, we did not observe any correlation between NK-, eosinophil- or neutrophil levels and PFS. In contrast, patients with low Tregs showed significantly improved PFS compared to those who had high levels. Treg counts negatively correlated with INF-γ serum concentrations and patients with high INF-γ and IL-18 had significantly improved survival compared to those with low levels.In conclusion, LTI of ch14.18/CHO in combination with IL-2 resulted in Treg induction that inversely correlated with IFN-γ levels and PFS.

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Section: Impact Of Il-2 and Ch1418/cho Treatment On Immune Cell Popumentioning

confidence: 62%

Low CD4⁺/CD25⁺/CD127⁻ regulatory T cell- and high INF-γ levels are associated with improved survival of neuroblastoma patients treated with long-term infusion of ch14.18/CHO combined with interleukin-2

et al. 2019

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“…Paraneoplastic reactive eosinophilia has been reported in both hematologic and solid malignancies including ovarian [ 5 , 6 ], bronchial [ 3 , 7 ], gastrointestinal [ 2 , 8 ], hepatic [ 9 ], renal [ 10 ] and thyroid [ 11 ] cancers, in addition to sarcoma [ 12 ]. Although pulmonary involvement can be seen in up to 25% of patients with HE and hypereosinophilic syndrome, asthma symptoms are uncommon [ [13] , [14] , [15] , [16] ].…”

Section: Discussionmentioning

confidence: 99%

“…Bone marrow biopsy showed hypercellular bone marrow (80%) with marked bone marrow eosinophilia. Genetic studies including BCR/ABL1, KIT Asp816Val & JAK2 V617F gene mutation analysis, florescent in situ hybridization (FISH) for CHIC2 (4q12) deletion, FGFR1 (8p11.2) rearrangement and PDGFRB/TEL translocation [ 5 , 12 ] were all negative.…”

Section: Case Presentationmentioning

confidence: 99%

Marked hypereosinophilia secondary to endometrioid ovarian cancer presenting with asthma symptoms, a case report

Albitar

Egan

Alkhateeb

et al. 2020

Respiratory Medicine Case Reports

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Background Hypereosinophilia (HE) is defined by the presence of >1.5 × 10 9 /L eosinophils in the peripheral blood. Paraneoplastic HE has been reported in a number of solid and hematologic malignancies including ovarian cancer. We present a case with paraneoplastic HE in the setting of underlying endometrioid ovarian carcinoma. Case presentation An 88-year-old woman presented with cough, dyspnea and 20-pound unintentional weight loss of one month duration. Evaluation revealed peripheral hypereosinophilia (HE) with absolute eosinophil count of 15.38 × 10 9 /L (53.8%) and an elevated exhaled nitric oxide at 172 parts per billion (normal < 39 PPB). Given the HE and unintentional weight loss, computed tomography (CT) scan was obtained and showed a pelvic mass. The patient underwent bilateral salpingo-ophorectomy with pathology consistent with endometrioid ovarian carcinoma. The patient experienced complete resolution of her cough, dyspnea, and peripheral eosinophilia following surgical resection. Conclusion This case highlights that solid malignancy should be considered in patients with marked HE.

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“…Two of the outliers (H11 and H17) showed an elevated platelet count and eosinophilia, respectively. Eosinophilia has been linked to a wide variety of non-neoplastic disorders, as well as to neoplastic conditions [37] and an elevation in eosinophils may exert protumor effects [38,39]. On the other hand, inflammation and platelet activation at the site of tissue damage is known to contribute to initiate a cascade of events, which promote tumorigenesis [40].…”

Section: Discussionmentioning

confidence: 99%

Predictive Value and Clinical Significance of Increased SSAT-1 Activity in Healthy Adults

et al. 2019

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Aim: Spermidine/spermine N1-acetyltransferase (SSAT-1) regulates cell growth, proliferation and death. Amantadine is converted by SSAT-1 to acetylamantadine (AA). In our earlier studies, although SSAT-1 was activated in patients with cancer, a number of ostensibly healthy adult volunteers had higher than expected AA concentration. This study was therefore undertaken to examine the outlier group. Materials & methods: A follow up of urine analysis for AA by liquid chromatography-tandem mass spectrometry as well as clinical assessments and additional blood analyses were conducted. Results: In some of the outlier controls, higher than expected AA concentration was linked to increased serum carcinoembryonic antigen. Clinical and radiographic assessments revealed underlying abnormalities in other cases that could represent premalignant conditions. Hematology tests revealed elevations in white blood cells and platelets, which are markers of inflammation. Conclusion: High urine concentration of AA could be used as a simple and useful test for screening of cancer in high-risk populations.

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How I investigate Eosinophilia

Cited by 25 publications

References 27 publications

Low CD4⁺/CD25⁺/CD127⁻ regulatory T cell- and high INF-γ levels are associated with improved survival of neuroblastoma patients treated with long-term infusion of ch14.18/CHO combined with interleukin-2

Low CD4⁺/CD25⁺/CD127⁻ regulatory T cell- and high INF-γ levels are associated with improved survival of neuroblastoma patients treated with long-term infusion of ch14.18/CHO combined with interleukin-2

Marked hypereosinophilia secondary to endometrioid ovarian cancer presenting with asthma symptoms, a case report

Predictive Value and Clinical Significance of Increased SSAT-1 Activity in Healthy Adults

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