How i do it head and neck and plastic surgery a targeted problem and its solution: Tetracycline sclerosis for treatment of benign lymphoepithelial cysts of the parotid gland in patients infected with human immunodeficiency virus

Echavez, Michael; Lee, K C; Sooy, C. Daniel

doi:10.1288/00005537-199412000-00013

Cited by 29 publications

(49 citation statements)

References 13 publications

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“…3,29 In the presence of an upper respiratory tract or bacterial superinfection of the cyst, the presentation may result in a more acute and painful course. 19 Because LPC parallels the previously described HIV lymphadenopathy syndrome, the majority of patients present relatively early in the course of the HIV infection before the onset of opportunistic infections or other symptomatic illness. 20 In many persons, the development of parotid enlargement with cysts is the initial manifestation of HIV disease, yet may not be diagnosed for many years.…”

Section: L I N I C a L P R E S E N T A T I O Nmentioning

confidence: 77%

“…[3][4][5]7,9,[12][13][14]18 In addition, several therapeutic approaches were recommended, the most common of which was surgical resection. 6,8,19 With a better understanding of the pathogenesis of HIV infection and LPC disease, coupled with the recent evolution of effective combination antiretroviral therapy to control HIV replication, medical treatment of LPC has emerged as the treatment of choice. 20 This article reviews the history of LPC pathogenesis and pathology, defines a clinical approach to management, and summarizes the impact of different therapies that have been tried over the past 15 years.…”

Section: Introductionmentioning

confidence: 99%

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Management of lymphoepithelial parotid cysts in HIV-infected adults

et al. 2000

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Section: L I N I C a L P R E S E N T A T I O Nmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Management of lymphoepithelial parotid cysts in HIV-infected adults

et al. 2000

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“…Tetracycline, doxycicline, and sodium morrhuate sclerosis have been used as a treatment for benign lymphoepithelial cysts of the parotid with optimal results [7][8][9]. Their efficacy as sclerosing agents are based on their low pH.…”

Section: Discussionmentioning

confidence: 99%

Sclerotherapy for the treatment of Warthin’s tumour of the parotid

Marrero¹,

Fons²,

Montero³

et al. 2012

OJST

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“…Tetracyclines (tetracycline, doxycycline, minocycline) have been used as sclerosing agents in various clinical settings such as pleural effusions [22,23] , pneumothoraces [24] , hydroceles [25] , benign lymphoepithelial cysts of the parotid gland [26] and lymphoceles after renal transplantation [27] . Although the mechanism underlying the sclerosing effect has been generally attributed to the results of local chemical irritation or infl ammatory response, Golub et al [28] discovered that minocycline possesses the ability to inhibit tissue collagenase.…”

Section: Discussionmentioning

confidence: 99%

Management of Pelvic Lymphocysts by Ultrasound-Guided Aspiration and Minocycline Sclerotherapy

Liu

Hung

Hwang

et al. 2005

Gynecol Obstet Invest

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Objective: The purpose of this study was to describe our experience with ultrasound-guided aspiration of postoperative pelvic lymphocysts followed by intracavitary minocycline injection as sclerotherapy. Patients and Methods: From 1997 to 2003, patients who developed either symptomatic or persistent lymphocyst after pelvic lymphadenectomy for gynecological malignancy were recruited in this study. All of the lymphocysts were palpable and were further examined by ultrasonography. Percutaneous ultrasound-guided needle aspiration of the lymphocyst was performed and then immediately followed by a single-dose injection of minocycline into the collapsed cavity. Follow-up was conducted every 4 weeks with pelvic examination and ultrasonography. Results: Nineteen patients with a total of 21 pelvic lymphocysts underwent this procedure. The median size of the lymphocysts was 6 cm in diameter (range, 4–9 cm). Fifteen patients received 1 treatment, 3 received 2, and 1 patient with bilateral lymphocysts received 3 treatments. Complete resolution occurred in 14 patients (74%), and the other 5 patients (26%) had partial resolution with the volume of the lymphocyst decreasing at least 50%. For the 14 patients with complete resolution, the median time from treatment to disappearance of the lymphocyst was 3 months (range, 1–10 months), and none of them developed recurrence during the average follow-up period of 40 months (range, 2–62 months). No significant complication occurred with this procedure except for transient mild to moderate pelvic pain. Discussion: Minocycline sclerotherapy seems to be a simple and safe method with a satisfactory success rate in treating lymphocysts which develop after pelvic lymphadenectomy. It can be performed in an outpatient setting and can be repeated if necessary. This procedure may be considered as the initial treatment modality for patients suffering from symptomatic or persistent lymphocysts after radical gynecological surgery.

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How i do it head and neck and plastic surgery a targeted problem and its solution: Tetracycline sclerosis for treatment of benign lymphoepithelial cysts of the parotid gland in patients infected with human immunodeficiency virus

Cited by 29 publications

References 13 publications

Management of lymphoepithelial parotid cysts in HIV-infected adults

Management of lymphoepithelial parotid cysts in HIV-infected adults

Sclerotherapy for the treatment of Warthin’s tumour of the parotid

Management of Pelvic Lymphocysts by Ultrasound-Guided Aspiration and Minocycline Sclerotherapy

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