How Hyperprolactinemia Affects Sexual Function in Patients Under Antipsychotic Treatment

Rubio‐Abadal, Elena; Cacho, N. Del; Saenz-Navarrete, G.; Arranz, Belén; Cambra, R. Molina; Cuadras, Daniel; Rodante, Demián; Fehér, Csaba; Roca, Mercedes; Barneda, V.; Usall, Judith

doi:10.1097/jcp.0000000000000539

Cited by 23 publications

(19 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The findings of the present study, of the association between hyperprolactinemia and sexual dysfunction have been supported by previous studies [14–17]. However, to our knowledge, this was the first study to assess the relationship between sexual dysfunction and subclinical hypothyroidism in patients with schizophrenia.…”

Section: Discussionsupporting

confidence: 90%

“…This view was supported by Kumari et al [13], who proposed that the Positive and Negative Syndrome Scale (PANSS) scores could be used to predict sexual dysfunction. Also, significantly increased serum levels of prolactin have been shown to be associated with sexual dysfunction, including lack of libido and erectile dysfunction, in both male and female patients with schizophrenia who were on antipsychotic treatment [14–17]. Therefore, in patients with schizophrenia, sexual dysfunction may occur as a result of antipsychotic medications and may be associated with the levels of specific sex hormones.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prolactin and Thyroid Stimulating Hormone (TSH) Levels and Sexual Dysfunction in Patients with Schizophrenia Treated with Conventional Antipsychotic Medication: A Cross-Sectional Study

et al. 2018

View full text Add to dashboard Cite

BackgroundThis study aimed to investigate the relationship between serum profiles of prolactin and thyroid stimulating hormone (TSH) and sexual dysfunction in patients with schizophrenia treated with conventional antipsychotic medication.Material/MethodsA hospital-based cross-sectional study included 118 patients, age range 18–57 years (55 men, 63 women), with a confirmed diagnosis of schizophrenia. All patients were stable after antipsychotic treatment. Serum levels of hormones, including prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone, testosterone, thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3) and free thyroxine (FT4), were detected in venous blood. The Positive and Negative Syndrome Scale (PANSS) score was used to measure symptom severity of patients with schizophrenia. The Mandarin Chinese version of the Arizona Sexual Experience Scale (ASEX), a 5-item scale, was used to measure sexual function.ResultsThere were 66 patients (55.9%) who had hyperprolactinemia, the prevalence of hyperprolactinemia was markedly higher in the sexual dysfunction group than the non-sexual dysfunction group (91.8% vs. 17.5%) (P<0.001). Mean prolactin levels were significantly increased in patients with sexual dysfunction compared with the patients without sexual dysfunction (P<0.001), with a higher incidence in female patients. Subclinical hypothyroidism and hyperprolactinemia were found to be independently associated with sexual dysfunction, and an increased PANSS negative score was an independent risk factor for the development of sexual dysfunction.ConclusionsThe incidence of sexual dysfunction was significantly increased in patients with schizophrenia. Hyperprolactinemia and subclinical hypothyroidism were associated with sexual dysfunction, especially in female patients.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Prolactin and Thyroid Stimulating Hormone (TSH) Levels and Sexual Dysfunction in Patients with Schizophrenia Treated with Conventional Antipsychotic Medication: A Cross-Sectional Study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The sexual side-effects of drugs interfering with cholinergic transmission are known for decades (Aldridge, 1982). Our results are consistent with those of a previous recent study (Rubio-Abadal et al, 2016). SZ women receiving anticholinergics have reported more than 4 times higher SD rates in our study, however only 10 SZ women were administered anticholinergics, which highlight the need to replicate this finding in a larger sample.…”

Section: Discussionsupporting

confidence: 93%

Sexual dysfunctions are associated with major depression, chronic inflammation and anticholinergic consumption in the real-world schizophrenia FACE-SZ national cohort

Fond

Godin

Dumontaud

et al. 2019

Progress in Neuro-Psychopharmacology and Biological Psychiatry

View full text Add to dashboard Cite

HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

show abstract

“…Some authors classify these iatrogenic reproductive disturbances as sexual dysfunctions, which has led to confounded results. 102,103 With regard to the effects of hyperprolactinemia on female libido, arousal and orgasm, there have been conflicting results, with several studies suggesting an association 89,104,105 and others finding no link. 16,98,106 Antipsychotics variably cause alpha-1 blockade, which has been associated with impairment of erection and ejaculation in men, as well as potential impairment of lubrication in women.…”

Section: Antipsychotic Induced Sexual Dysfunctionmentioning

confidence: 99%

Women’s sexual dysfunction associated with psychiatric disorders and their treatment

Basson

Gilks

2018

Womens Health (Lond Engl)

140

106

View full text Add to dashboard Cite

Impairment of mental health is the most important risk factor for female sexual dysfunction. Women living with psychiatric illness, despite their frequent sexual difficulties, consider sexuality to be an important aspect of their quality of life. Antidepressant and antipsychotic medication, the neurobiology and symptoms of the illness, past trauma, difficulties in establishing relationships and stigmatization can all contribute to sexual dysfunction. Low sexual desire is strongly linked to depression. Lack of subjective arousal and pleasure are linked to trait anxiety: the sensations of physical sexual arousal may lead to fear rather than to pleasure. The most common type of sexual pain is 10 times more common in women with previous diagnoses of anxiety disorder. Clinicians often do not routinely inquire about their patients' sexual concerns, particularly in the context of psychotic illness but careful assessment, diagnosis and explanation of their situation is necessary and in keeping with patients' wishes. Evidence-based pharmacological and non-pharmacological interventions are available but poorly researched in the context of psychotic illness.

show abstract

How Hyperprolactinemia Affects Sexual Function in Patients Under Antipsychotic Treatment

Cited by 23 publications

References 47 publications

Prolactin and Thyroid Stimulating Hormone (TSH) Levels and Sexual Dysfunction in Patients with Schizophrenia Treated with Conventional Antipsychotic Medication: A Cross-Sectional Study

Prolactin and Thyroid Stimulating Hormone (TSH) Levels and Sexual Dysfunction in Patients with Schizophrenia Treated with Conventional Antipsychotic Medication: A Cross-Sectional Study

Sexual dysfunctions are associated with major depression, chronic inflammation and anticholinergic consumption in the real-world schizophrenia FACE-SZ national cohort

Women’s sexual dysfunction associated with psychiatric disorders and their treatment

Contact Info

Product

Resources

About