How heterogeneous thymic output and homeostatic proliferation shape naive T cell receptor clone abundance distributions

Understanding how T helper cells learn to coordinate effective immune responses through the lens of reinforcement learning

“…This coincidence implies that a simple mechanism underlies the generation of power-law like distributions irre- spective of the details of the dynamics. In previous theoretical analyses, the symmetric variation in the fitness of clones was proposed as the mechanism of the power-law distribution [54,55]. Similar symmetric fitness variations are also observed in Fig.…”