How Guillain-Barre patients experience their functioning after 1 year

Bernsen, R.A.J.A.M.; Jager, A.E.J. de; Meché, F. G. A. Van Der; Suurmeijer, T

doi:10.1111/j.1600-0404.2005.00429.x

Cited by 38 publications

(36 citation statements)

References 16 publications

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“…The GBS survivors made good functional recovery (median motor FIM score = 90) consistent with other studies [16,[22][23][24][25]. Participants reported residual neurological deficits (motor and sensory) [9,16,26] and minimal change in their physical status in relation to time elapsed since GBS. This is similar to other reports [17,25] that suggest that, at 2-3 years after GBS, there is no substantial expectation of recovery.…”

Section: Discussionsupporting

confidence: 83%

“…The distal motor weakness, sensory impairment and psychological problems can result in persistent disability [3,[9][10][11]. Although the majority of GBS survivors (75%) have a good outcome (the ability to walk independently) [12], the impact of GBS on activities of daily living, work, social activities and quality of life (QoL) is considerable at 2 years after onset and persists beyond this time [13].…”

Section: Introductionmentioning

confidence: 99%

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Factors associated with long-term functional outcomes and psychological sequelae in Guillain–Barre syndrome

Khan

Pallant

et al. 2010

J Neurol

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Factors associated with long-term functional outcomes and psychological sequelae in Guillain–Barre syndrome

Khan

Pallant

et al. 2010

J Neurol

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“…However, over 20% of patients still noticed improvement 2.5–6.5 years after onset. The same authors in 2005 also published findings relating to the same population, in terms of patients' experience of their functioning after 1 year 25. Only 33% felt subjectively completely cured at 1 year.…”

Section: Resultsmentioning

confidence: 95%

Outcome and its predictors in Guillain–Barré syndrome

Rajabally

Uncini

2012

J Neurol Neurosurg Psychiatry

196

170

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Despite the use of plasma exchanges and intravenous immunoglobulins, Guillain-Barré syndrome (GBS) still carries non-negligible morbidity and mortality. Furthermore, the psychosocial consequences of GBS may persist longer than expected. Various aetiological, clinical, electrophysiological and immunological factors may carry prognostic predictive value. The objective of this article was to perform a summary of the current knowledge-base on outcome and its determinants in adequately-treated adult-onset GBS. Relevant prospective literature was reviewed through a Medline search of English-language articles published between 1966 and March 2012. GBS causes severe persistent disability in 14% of patients at 1 year. Loss of full strength, persistent pain and need for professional change occurs in about 40%. Mortality is of about 4% within the first year. Analysis of prognostic predictors consistently demonstrates the negative impact of higher age, preceding diarrhoea, greater disability/weaker muscles at admission, short interval between symptomonset and admission, mechanical ventilation and absent/ low amplitude compound muscle action potentials. Further outcome studies will soon be underway and may in future contribute to adequately integrate all potential factors in more reliable predictive models.

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“…Despite the frequent use of these treatments, many patients still have diminished power and sensation 1 year after onset, often with disturbing effects. 5 Patients and physicians therefore require more effective therapies that are based on full knowledge of the syndrome's molecular pathogenesis.…”

mentioning

confidence: 99%

Ganglioside mimicry and peripheral nerve disease

Yuki

2007

Muscle and Nerve

125

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Four criteria must be satisfied to conclude that a given microorganism causes Guillain-Barré (GBS) or Fisher (FS) syndrome associated with anti-ganglioside antibodies: (1) an epidemiological association between the infecting microbe and GBS or FS; (2) isolation in the acute progressive phase of illness of that microorganism from GBS or FS patients with associated anti-ganglioside IgG antibodies; (3) identification of a microbial ganglioside mimic; and (4) a GBS or FS with associated anti-ganglioside antibodies model produced by sensitization with the microbe itself or its component, as well as with ganglioside. Campylobacter jejuni is a definitive causative microorganism of acute motor axonal neuropathy and may cause FS and related conditions. Haemophilus influenzae and Mycoplasma pneumoniae are possible causative microorganisms of acute motor axonal neuropathy or FS. Acute and chronic inflammatory demyelinating polyneuropathies may be produced by mechanisms other than ganglioside mimicry.

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How Guillain-Barre patients experience their functioning after 1 year

Abstract: One year after the onset of GBS, a considerable number of patients still perceived a decrease of power and sensation with an often disturbing effect. GBS had an evident impact on daily life and social well-being.

Cited by 38 publications

References 16 publications

Factors associated with long-term functional outcomes and psychological sequelae in Guillain–Barre syndrome

Factors associated with long-term functional outcomes and psychological sequelae in Guillain–Barre syndrome

Outcome and its predictors in Guillain–Barré syndrome

Ganglioside mimicry and peripheral nerve disease

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