2018
DOI: 10.1016/j.mayocp.2017.12.020
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How Good Intentions Contributed to Bad Outcomes: The Opioid Crisis

Abstract: The opioid crisis that exists today developed over the past 30 years. The reasons for this are many. Good intentions to improve pain and suffering led to increased prescribing of opioids, which contributed to misuse of opioids and even death. Following the publication of a short letter to the editor in a major medical journal declaring that those with chronic pain who received opioids rarely became addicted, prescriber attitude toward opioid use changed. Opioids were no longer reserved for treatment of acute p… Show more

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Cited by 157 publications
(157 citation statements)
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References 33 publications
(27 reference statements)
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“…However, an increased emphasis on pain relief by regulators and payers, changes in prescriber attitudes about the risks and benefits of opioids, and marketing campaigns by manufacturers led to large increases in opioid use in patients with chronic noncancer pain. There was an increase in opioid prescriptions of 45 million in 2002 compared with 5 years earlier, and almost 62 million Americans filled one or more opioid prescriptions in 2016 . Both weak opioids, such as codeine and dihydrocodeine, and strong opioids, including morphine and related drugs, are now frequently used to control chronic pain once NSAIDs alone are no longer effective .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…However, an increased emphasis on pain relief by regulators and payers, changes in prescriber attitudes about the risks and benefits of opioids, and marketing campaigns by manufacturers led to large increases in opioid use in patients with chronic noncancer pain. There was an increase in opioid prescriptions of 45 million in 2002 compared with 5 years earlier, and almost 62 million Americans filled one or more opioid prescriptions in 2016 . Both weak opioids, such as codeine and dihydrocodeine, and strong opioids, including morphine and related drugs, are now frequently used to control chronic pain once NSAIDs alone are no longer effective .…”
Section: Introductionmentioning
confidence: 99%
“…There was an increase in opioid prescriptions of 45 million in 2002 compared with 5 years earlier, and almost 62 million Americans filled one or more opioid prescriptions in 2016. 7 Both weak opioids, such as codeine and dihydrocodeine, and strong opioids, including morphine and related drugs, are now frequently used to control chronic pain once NSAIDs alone are no longer effective. 6 Although conventional opioid analgesics are routinely used to treat chronic, noncancer pain, the evidence that they are effective for this indication are sparse.…”
Section: Introductionmentioning
confidence: 99%
“…The majority of these overdose deaths were unintentional . Increases in overdose deaths have been linked to increases in opioid use for chronic non‐cancer pain (CNCP) . Although the prevalence of opioid use has stabilized in North America and Australia since 2012 , there is ongoing concern about high‐dose opioid use .…”
Section: Introductionmentioning
confidence: 99%
“…By targeting lay people, this form of marketing creates millions of Molière's “ malades imaginaires” and new false markets that increase costs, and can be harmful. It contributed to the current opioid tragedy in the U.S., which in 2017 caused the addiction of 3 million individuals and 70 000 + overdose deaths . Advertisements may convince Americans to support pharma strategies that sustain high drug prices, as exemplified by the massive “Go Boldly” campaign, paid for by PhRMA, which delivers the subliminal message that if drug prices are controlled, discoveries that cure Alzheimer's disease and dementia will not happen .…”
Section: The “American Patients First” Blueprintmentioning
confidence: 99%