How gap distance between gold nanoparticles in dimers and trimers on metallic and non-metallic SERS substrates can impact signal enhancement

Arbuz, Alexandr; Sultangaziyev, Alisher; Rapikov, Alisher; Kunushpayeva, Zhanar; Bukasov, Rostislav

doi:10.1039/d1na00114k

Cited by 26 publications

(18 citation statements)

References 81 publications

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“…A high surface density and a short distance between nanoparticles increase the number of active hot spots and improve the SERS enhancement factor [ 43 ]. For instance, SERS enhancement at the surface of the gold nanoparticle dimers on various substrates can be 1.5–2× (on gold, silver, and Al film) or even 10+× (on silicon) higher than SERS enhancement of single nanoparticles on the same substrate [ 25 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…Al foil is a promising non-conventional substrates for SERS, which is not only easily and readily available in most places of the world, but it may also have better resistance to contamination and non-specific protein binding in bio-sensing applications [ 23 ]. Al foil has been reported as an SERS and SEF substrate in a number of sensing and bio-sensing applications [ 24 , 25 , 26 , 27 ]. Silicon has a lower cost and higher stability/resistance to contamination/oxidation in comparison to silver and gold substrates, which are prone to contamination/non-specific binding from S-containing compounds, including proteins, especially due to Au-S and Ag-S dative bonding [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

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SERS for Detection of Proteinuria: A Comparison of Gold, Silver, Al Tape, and Silicon Substrates for Identification of Elevated Protein Concentration in Urine

Aitekenov

Sultangaziyev

Boranova

et al. 2023

Sensors

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Excessive protein excretion in human urine is an early and sensitive marker of diabetic nephropathy and primary and secondary renal disease. Kidney problems, particularly chronic kidney disease, remain among the few growing causes of mortality in the world. Therefore, it is important to develop an efficient, expressive, and low-cost method for protein determination. Surface enhanced Raman spectroscopy (SERS) methods are potential candidates to achieve these criteria. In this paper, a SERS method was developed to distinguish patients with proteinuria from the healthy group. Commercial gold nanoparticles (AuNPs) with diameters of 60 nm and 100 nm, and silver nanoparticles (AgNPs) with a diameter of 100 nm were tested on the surface of four different substrates including silver and gold films, silicon, and aluminum tape. SERS spectra were acquired from 111 unique human urine samples prepared and measured for each of the seven different nanoparticle plus substrate combinations. Data analysis by the PCA-LDA algorithm and the ROC curves gave results for the diagnostic figures of merits. The best sensitivity, specificity, accuracy, and AUC were 0.91, 0.84, 0.88, and 0.94 for the set with 100 nm Au NPs on the silver substrate, respectively. Among the three metal substrates, the substrate with AuNPs and Al tape performed slightly worse than the other three substrates, and 100 nm gold nanoparticles on average produced better results than 60 nm gold nanoparticles. The 60 nm diameter AuNPs and silicon, which is about one order of magnitude more cost-effective than AuNPs and gold film, showed a relative performance close to the performance of 60 nm AuNPs and Au film (average AUC 0.88 (Si) vs. 0.89 (Au)). This is likely the first reported application of unmodified silicon in SERS substrates applied for direct detection of proteins in any biofluid, particularly in urine. These results position silicon and AuNPs@Si in particular as a perspective SERS substrate for direct urine analysis, including clinical diagnostics of proteinuria.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

SERS for Detection of Proteinuria: A Comparison of Gold, Silver, Al Tape, and Silicon Substrates for Identification of Elevated Protein Concentration in Urine

Aitekenov

Sultangaziyev

Boranova

et al. 2023

Sensors

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“…The SERS as a field-deployable, label-free, and non-destructive technique is able to detect biomarkers for early diagnosis of diseases using the Raman signals amplified by AuNPs [ 88 ]. So, AuNPs have been widely used as the effective SERS substrates in the configuration of biosensors [ 89 ]. The SERS nanotags are fabricated by binding strong Raman active molecules to AuNPs [ 90 ].…”

Section: Sers-based Sensing Methodsmentioning

confidence: 99%

AuNP-based biosensors for the diagnosis of pathogenic human coronaviruses: COVID-19 pandemic developments

2022

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The outbreak rate of human coronaviruses (CoVs) especially highly pathogenic CoVs is increasing alarmingly. Early detection of these viruses allows treatment interventions to be provided more quickly to people at higher risk, as well as helping to identify asymptomatic carriers and isolate them as quickly as possible, thus preventing the disease transmission chain. The current diagnostic methods such as RT-PCR are not ideal due to high cost, low accuracy, low speed, and probability of false results. Therefore, a reliable and accurate method for the detection of CoVs in biofluids can become a front-line tool in order to deal with the spread of these deadly viruses. Currently, the nanomaterial-based sensing devices for detection of human coronaviruses from laboratory diagnosis to point-of-care (PoC) diagnosis are progressing rapidly. Gold nanoparticles (AuNPs) have revolutionized the field of biosensors because of the outstanding optical and electrochemical properties. In this review paper, a detailed overview of AuNP-based biosensing strategies with the varied transducers (electrochemical, optical, etc.) and also different biomarkers (protein antigens and nucleic acids) was presented for the detection of human coronaviruses including SARS-CoV-2, SARS-CoV-1, and MERS-CoV and lowly pathogenic CoVs. The present review highlights the newest trends in the SARS-CoV-2 nanobiosensors from the beginning of the COVID-19 epidemic until 2022. We hope that the presented examples in this review paper convince readers that AuNPs are a suitable platform for the designing of biosensors. Graphical abstract

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“…One of the possible alternatives for conventional plasmonic metals is aluminum, which is plasmon tunable in a relatively broad UV and visible range and passivated by a thin layer of oxide [ 35 ]. There were reports of the application of aluminum as inexpensive, versatile and sensitive substrate for SERS, with excitation in the visible range [ 35 , 36 , 37 , 38 , 39 , 40 ]. In addition, Al was reported as a substrate for Surface-Enhanced Fluorescence (SEF) spectroscopy, which could compete with and sometimes outperform typical SEF substrates such as gold and silver [ 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Trends in Application of SERS Substrates beyond Ag and Au, and Their Role in Bioanalysis

et al. 2022

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This article compares the applications of traditional gold and silver-based SERS substrates and less conventional (Pd/Pt, Cu, Al, Si-based) SERS substrates, focusing on sensing, biosensing, and clinical analysis. In recent decades plethora of new biosensing and clinical SERS applications have fueled the search for more cost-effective, scalable, and stable substrates since traditional gold and silver-based substrates are quite expensive, prone to corrosion, contamination and non-specific binding, particularly by S-containing compounds. Following that, we briefly described our experimental experience with Si and Al-based SERS substrates and systematically analyzed the literature on SERS on substrate materials such as Pd/Pt, Cu, Al, and Si. We tabulated and discussed figures of merit such as enhancement factor (EF) and limit of detection (LOD) from analytical applications of these substrates. The results of the comparison showed that Pd/Pt substrates are not practical due to their high cost; Cu-based substrates are less stable and produce lower signal enhancement. Si and Al-based substrates showed promising results, particularly in combination with gold and silver nanostructures since they could produce comparable EFs and LODs as conventional substrates. In addition, their stability and relatively low cost make them viable alternatives for gold and silver-based substrates. Finally, this review highlighted and compared the clinical performance of non-traditional SERS substrates and traditional gold and silver SERS substrates. We discovered that if we take the average sensitivity, specificity, and accuracy of clinical SERS assays reported in the literature, those parameters, particularly accuracy (93–94%), are similar for SERS bioassays on AgNP@Al, Si-based, Au-based, and Ag-based substrates. We hope that this review will encourage research into SERS biosensing on aluminum, silicon, and some other substrates. These Al and Si based substrates may respond efficiently to the major challenges to the SERS practical application. For instance, they may be not only less expensive, e.g., Al foil, but also in some cases more selective and sometimes more reproducible, when compared to gold-only or silver-only based SERS substrates. Overall, it may result in a greater diversity of applicable SERS substrates, allowing for better optimization and selection of the SERS substrate for a specific sensing/biosensing or clinical application.

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How gap distance between gold nanoparticles in dimers and trimers on metallic and non-metallic SERS substrates can impact signal enhancement

Abstract: SERS AuNP EF dimer/EF monomer vs. gap, nm (y = e−x) on Au, Ag, Al, Si, 1220+ nanoantennae.

Cited by 26 publications

References 81 publications

SERS for Detection of Proteinuria: A Comparison of Gold, Silver, Al Tape, and Silicon Substrates for Identification of Elevated Protein Concentration in Urine

SERS for Detection of Proteinuria: A Comparison of Gold, Silver, Al Tape, and Silicon Substrates for Identification of Elevated Protein Concentration in Urine

AuNP-based biosensors for the diagnosis of pathogenic human coronaviruses: COVID-19 pandemic developments

Trends in Application of SERS Substrates beyond Ag and Au, and Their Role in Bioanalysis

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