How embodied is action language? Neurological evidence from motor diseases

Cardona, Juan F.; Kargieman, Lucila; Sinay, Vladimiro; Gershanik, Oscar S.; Gelormini, Carlos; Amoruso, Lucía; Roca, María; Pineda, David; Trujillo, Natalia; Michon, Maëva; García, Adolfo M.; Szenkman, Daniela; Bekinschtein, Tristán A.; Manes, Facundo; Ibáñez, Agustín

doi:10.1016/j.cognition.2014.02.001

Cited by 79 publications

(85 citation statements)

References 76 publications

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“…The ACE paradigm is well-suited for this study, since it recruits both motor and semantic brain areas, and has proved sensitive to deficits in other subcortical motor disorders (e.g., Parkinson’s disease) (Aravena et al, 2010; Ibanez et al, 2013). Moreover, the ACE task is unaffected by peripheral motor impairments (Cardona et al, 2014), which further underscores its relevance to the present study. Participants listened to sentences that described an action performed with the hand in a particular shape (open: OH, n = 52, or closed: CH, n = 52), as well as neutral sentences alluding to non-manual actions (neutral: N, n = 52).…”

Section: Methodssupporting

confidence: 68%

Motorâ€“Language Coupling in Huntingtonâ€™s Disease Families

Kargieman

Herrera

Báez

et al. 2014

Front. Aging Neurosci.

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Traditionally, Huntington’s disease (HD) has been known as a movement disorder, characterized by motor, psychiatric, and cognitive impairments. Recent studies have shown that motor and action–language processes are neurally associated. The cognitive mechanisms underlying this interaction have been investigated through the action compatibility effect (ACE) paradigm, which induces a contextual coupling of ongoing motor actions and verbal processing. The present study is the first to use the ACE paradigm to evaluate action–word processing in HD patients (HDP) and their families. Specifically, we tested three groups: HDP, healthy first-degree relatives (HDR), and non-relative healthy controls. The results showed that ACE was abolished in HDP as well as HDR, but not in controls. Furthermore, we found that the processing deficits were primarily linguistic, given that they did not correlate executive function measurements. Our overall results underscore the role of cortico-basal ganglia circuits in action–word processing and indicate that the ACE task is a sensitive and robust early biomarker of HD and familial vulnerability.

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Section: Methodssupporting

confidence: 68%

Motorâ€“Language Coupling in Huntingtonâ€™s Disease Families

Kargieman

Herrera

Báez

et al. 2014

Front. Aging Neurosci.

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“…It is also worth noting that recent research on verb use by Spanish-speaking participants with brain pathologies such as Parkinson's disease (Cardona et al, 2014;Herrera, Rodríguez-Ferreiro, & Cuetos, 2012) is contributing to understand the lexical and semantic organization of verbs through the study of patterns of differential degradation. Because AoA has been demonstrated to modulate verb processing in both unimpaired and language-impaired populations (e.g., Bradley, Davies, Parris, Su, & Weekes, 2006;De Bleser & Kauschke, 2003) it is reasonable to expect informative AoA modulation of verb use in specific pathologies, with differential patterns being related to the prevailing difficulties (perceptual, motor, etc.…”

Section: Discussionmentioning

confidence: 99%

Subjective age-of-acquisition norms for 4,640 verbs in Spanish

2015

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Many studies have shown that how words are processed in a variety of language-related tasks is affected by their age of acquisition (AoA). Most AoA norms have been collected for nouns, a fact that limits the extent to which verb stimuli can be adequately manipulated and controlled in empirical studies. With the aim of increasing the number of verbs with AoA values in Spanish, 900 college students were recruited to provide subjective estimates for a total of 4,640 infinitive and reflexive forms. An AoA score for each verb was obtained by averaging the responses of the participants, and these norms were included, together with additional quantitative information (standard deviations, ranges, and z scores), in a database that can be downloaded with this article as supplemental materials.

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“…Finally, a study comparing motorlanguage coupling in early PD, neuromyelitis optica, and acute transverse myelitis, indicated that deficits in the integration of action verbs and manual actions result from atrophy of cortico-subcortical motor network system, and not from peripheral (musculoskeletal) motor system affectation [35].…”

Section: Action-language Impairments In Parkinson's Diseasementioning

confidence: 99%

Words in motion: Motor-language coupling in Parkinson’s disease

García¹,

Ibáñez²

2014

Translational Neuroscience

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In recent years, the disruption of non-motor functions in motor disease has emerged as a promising topic for both basic and translational neuroscience. Impairments of movement and cognition were long regarded as separate phenomena [1]. However, a growing body of evidence indicates that neurodegenerative motor disorders also involve high-order cognitive dysfunctions, ranging from working memory, attention, and executive processing deficits [2][3][4], to impairments of language [4][5][6][7][8][9][10] and action knowledge [11]. Further data comes from studies showing that the same genes (e.g., C9orf72) are involved in diseases once perceived as purely motor or purely cognitive, such as motor neuron disease (MND) and frontotemporal dementia, respectively [12].A cognitive domain which seems to be specifically compromised in motor diseases is action language, that is, processing of linguistic stimuli denoting motor actions, including idioms (e.g., cut a rug) and action verbs Words in moTion: moTor-lAnguAge couPling in PArkinson's diseAse Abstract A growing body of evidence indicates that neurodegenerative motor disorders involved high-order cognitive dysfunctions. Crucially, evidence obtained in multiple behavioral, neuroimaging, and electrophysiological studies points to selective impairments of action language -that is, processing of linguistic stimuli denoting motor actions, including idioms (e.g., cut a rug) and action verbs (e.g., clap). Action-verb deficits (with relative preservation of noun processing) have been repeatedly documented in Parkinson's disease (PD). However, research on relevant biomarkers is still scant, and clinical implications of these findings have not yet been formally discussed. Relevant insights may be obtained through the assessment of motor-language coupling (i.e., the behavioral and neural integration of action-verb processing and ongoing motor actions). We propose that motorlanguage coupling deficits, as indexed by a cortical-subcortical network, may constitute an early neurocognitive marker of PD. Specifically, deficits in this domain at the prodromal stage may be detected through the actionsentence compatibility (ACE) paradigm, which induces a contextual coupling of ongoing motor actions and action-verb processing. Our translational proposal is supported and illustrated by recent studies demonstrating the sensitivity of the ACE technique as well as its potential to assist in differential diagnosis and interventionprogram design.

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How embodied is action language? Neurological evidence from motor diseases

Cited by 79 publications

References 76 publications

Motorâ€“Language Coupling in Huntingtonâ€™s Disease Families

Motorâ€“Language Coupling in Huntingtonâ€™s Disease Families

Subjective age-of-acquisition norms for 4,640 verbs in Spanish

Words in motion: Motor-language coupling in Parkinson’s disease

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