How Does Usage of Serotonin Noradrenaline Reuptake Inhibitors Affect Intraocular Pressure in Depression Patients?

Gündüz, Gamze Uçan; Yener, Neslihan Parmak; Kılınçel, Oğuzhan; Gündüz, Cem

doi:10.1089/jop.2017.0133

Cited by 6 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(2) Endurance training was associated with wide variations in plasma levels of a number of other neurotransmitters and hormones that may have different effects on the control of IOP. Amongst them, serotonin was shown to be significantly reduced by regular training 29 , and cross-sectional studies of patients using serotonin reuptake inhibitors have suggested an association between lower levels of serotonin and higher IOP 30 . (3) Since the intensity of the activity was not recorded, intense Walking or cycling, either uphill or for extended periods of time, might have had the same physiological effect as resistance training.…”

Section: Discussionmentioning

confidence: 99%

The effect of daily life activities on intraocular pressure related variations in open-angle glaucoma

Gillmann

Weinreb

Mansouri

2021

Sci Rep

View full text Add to dashboard Cite

The recent advent of continuous intraocular pressure (IOP) telemetry has led to an increased awareness of the importance of IOP fluctuations, and theories have emerged that IOP variations could play as much a role in glaucoma progression as the mean level of IOP. The aim of the present study was to evaluate the direct effect of common daily activities on IOP-related profiles. Primary open-angle glaucoma and glaucoma suspect patients were prospectively enrolled from specialist clinics at the University of California San Diego (UCSD), USA. Patients were fitted with a SENSIMED Triggerfish (TF) contact lens sensor (CLS) and were instructed to return to their usual daily activities for 24 h. They were asked to record each specific activity or event in a diary. The protocol was repeated twice. The following events were recorded: “walking/cycling”, “resistance training”, “yoga/meditation”, and “emotional stress”. CLS measurements recorded 60-to-30 min prior to each event were used as a baseline reference, and all IOP-related fluctuations for 120 min after the start of each event were reported in relation to this reference. Forty relevant events from 22 CLS recordings in 14 patients were retrieved from the diaries. Walking/cycling (n = 10) caused a small but statistically significant elevation of the IOP-related profile during the activity (p = 0.018). Resistance training (n = 11) caused a persistent elevation of the IOP-related profile from the onset of the activity (p = 0.005) through 120 min after the activity was stopped (p = 0.007). Yoga/meditation (n = 4) caused a sustained drop in the IOP-related profiles through to 120 min, although this was not statistically significant (p > 0.380). Emotional stress (n = 13) was associated with a gradual elevation of the IOP-related profile from the start of the stressful stimulus. Both early and late variations were statistically significant (p = 0.038 and p = 0.021, respectively). The present study suggests that emotional stress and resistance training may be associated with persistent IOP-related profile elevation.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of daily life activities on intraocular pressure related variations in open-angle glaucoma

Gillmann

Weinreb

Mansouri

2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…However, current data suggest that the systemic usage of SNRI could lead in long-term treatment to a decrease in the IOP. Another possible cause of mydriasis due to SNRI treatment would be the stimulation of serotoninergic receptors, mainly 5HT7, which in turn could lead to relaxation of the sphincter muscle [29,32]. ↑IOP [40] ↑, increased; ↓, decreased; IOP, intraocular pressure; 5HT, 5-hydroxytryptamine (serotonin); DA, dopamine; TNF, tumour necrosis factor; R, receptor.…”

Section: Selective Serotonin Reuptake Inhibitors (Ssris) and Serotonin And Noradrenaline Reuptake Inhibitors (Snris)mentioning

confidence: 99%

Psychopharmacological Treatment, Intraocular Pressure and the Risk of Glaucoma: A Review of Literature

Ciobanu

Dionisie

Neagu

et al. 2021

JCM

View full text Add to dashboard Cite

Through the years, the available psychopharmacological treatments have expanded with numerous new drugs. Besides weight gain, gastro-intestinal problems or Parkinson-like symptoms, ocular adverse effects of psychiatric drugs have been reported. These adverse effects are not common, but can be dangerous for the patient. This review summarises the current knowledge on the risk of raised intraocular pressure and glaucoma entailed by psychopharmacological treatment. Also, it provides updated data for clinicians involved in the treatment of patients with glaucoma or glaucoma risk factors. For this purpose, we performed an extensive literature search in the PubMed database using specific terms. Selective serotonin and noradrenaline reuptake inhibitors are the best evidenced as having no association with glaucoma. Antipsychotics, and especially first generation, seem to have no correlation with an increased intraocular pressure and therefore possibly with a risk of glaucoma, although a special attention should be paid when using ziprasidone. Tricyclic antidepressants, benzodiazepines and topiramate should be avoided in patients diagnosed with glaucoma or at risk. Clinicians should be aware of the possible psychotropic drug induced glaucoma and monitor at risk patients closely in order to prevent this condition. Irrespective of the psychopharmacological regimen taken into consideration, the glaucoma patient should be under the strict supervision of the ophthalmologist.

show abstract

“…The surrounding environment can help them to reacquire their happiness and interest in the world. [6][7][8]…”

Section: Drugsmentioning

confidence: 99%

A Review and Conjectures of Therapies for Depression

Aiyang¹

2021

Advances in Social Science, Education and Humanities Research

View full text Add to dashboard Cite

In this review, various treatment methods of depression, corresponding to their different symptoms and conditions have been reviewed. Also, study for the inflammatory mechanism, through stem cell therapy, MECT treatment (severe ones), and conventional drug treatment, analysis for the targets and variation sites of different kinds of inflammation, inhibit the development of the disease have been presented. In the future, the development of treatment methods will transfer to gene therapy.

show abstract

How Does Usage of Serotonin Noradrenaline Reuptake Inhibitors Affect Intraocular Pressure in Depression Patients?

Abstract: Treatment of SNRIs causes mydriasis and decrease in width of ACD. These changes may not increase IOP as long as the patient has an open angle. SNRIs lead to decrease in IOP particularly in long-term usage.

Cited by 6 publications

References 28 publications

The effect of daily life activities on intraocular pressure related variations in open-angle glaucoma

The effect of daily life activities on intraocular pressure related variations in open-angle glaucoma

Psychopharmacological Treatment, Intraocular Pressure and the Risk of Glaucoma: A Review of Literature

A Review and Conjectures of Therapies for Depression

Contact Info

Product

Resources

About