How does thiol/disulfide homeostasis change in children with type 1 diabetes mellitus?

Durmuş, Sevgi Yaşar; Şahin, Nursel; Ergin, Merve; Neşelioğlu, Salih; Aycan, Zehra; Erel, Özcan

doi:10.1016/j.diabres.2019.01.027

Cited by 8 publications

(1 citation statement)

References 17 publications

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“…Therefore, deterioration of oxidative balance could cause abnormalities at structural and functional levels. 6,[9][10][11][12][13][14][15] In the literature, change in the thiol/disulphide homeostasis has been shown in diabetes mellitus, cardiovascular disorders, malignancy, rheumatoid arthritis, adenoid hypertrophy, acute pancreatitis, otitis media, β -thalassemia major, placenta percreta, inflammatory bowel diseases, rosacea and chronic kidney failure. [9][10][11][12][13][14][15] Another study by Atasever et al also investigated the thiol/disulphide homeostasis in ovarian torsion.…”

Section: Discussionmentioning

confidence: 99%

Thiol-Disulphide Homeostasis in Ovarian Torsion-Detorsion: An Experimental Rat Model

Avcı¹,

Huyut²,

Altındağ³

et al. 2020

J Clin Obstet Gynecol

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Ovarian torsion is one of the reasons of acute abdomen requiring immediate surgical intervention. There is not any reliable method for its diagnosis. Delay in treatment may result in loss of ovary. In this study, the purpose is to evaluate efficiency of thioldisulphide homeostasis in early diagnosis of ovarian torsion in experimental rat model and in its follow-up care with biochemical and histopathological findings. Material and Methods: In the study, 24 Albino Wistar female rats were divided into three groups. The first group was the sham group. The second group was the torsion group. The last group was the torsion-detorsion group. Histopathological evaluation was carried out in ovaries in all groups, and values of thiol/disulphide homeostasis were measured in serum samples biochemically. Results: Values of native thiol and total thiol were lower in the torsion-detorsion group compared to the other groups. However, there was no significant difference between of native thiol and total thiol levels in the sham and torsion groups. Interestingly, the index of native thiol/total thiol was relatively low in the torsion and torsion-detorsion groups compared to the sham group. However, this decrease was not significant. Conclusion: These results suggest that native thiol/total thiol values may not be useful for early diagnosis of ovarian torsion but it may be used for follow-up care after detorsion

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