How does the pulsed laser turn into ‘force’?

Lu, Guoxin; Li, Jing; Ji, Zhong; Li, Heng; Yao, Changfeng; Li, Jinshan; Sugioka, Koji; Zhao, Guoqun

doi:10.1016/j.measurement.2021.110016

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…For an interval of less than 5 μs between the first and second femtosecond pulses, the second pulse is focused in the cavitation bubble rather than in the fluid. An insufficient time interval between femtosecond pulses could cause the second cavitation bubble and impulse force to fail, since there might not be enough fluid for cavitation 43 , 45 . Besides, the impulsive force consists of positive and negative forces generated by the expansion and collapse of the cavitation bubble, respectively 29 .…”

Section: Discussionmentioning

confidence: 99%

Microsecond cell triple-sorting enabled by multiple pulse irradiation of femtosecond laser

Kiya

Tang

Tanaka

et al. 2023

Sci Rep

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Femtosecond-laser-assisted cell manipulation, as one of the high throughput cell sorting techniques, is tailored for single-step multiple sorting based on controllable impulsive force. In this paper, femtosecond laser pulses are focused within a pocket structure and they induce an impulse force acting on the flowing objects. The impulsive force is shown to be controllable by a new method to adjust the femtosecond pulse properties. This allows precise streamline manipulation of objects having various physical qualities (e.g., weight and volume). The pulse energy, pulse number, and pulse interval of the femtosecond laser are altered to determine the impulsive force strength. The method is validated in single cell or bead triple-sorting experiments and its capability to perform streamline manipulation in as little as 10 μs is shown. The shift profiles of the beads acting under the impulsive force are studied in order to better understand the sorting mechanism. Additionally, beads and cells with different fluorescence intensities are successfully detected and directed into different microchannels, with maximum success rates of 90% and 64.5%, respectively. To sum up, all results suggest that this method has the potential to sort arbitrary subpopulations by altering the number of femtosecond pulses and that it takes the first step toward developing a single-step multi-selective system.

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Section: Discussionmentioning

confidence: 99%