How does the pattern of aeroallergen sensitization change over time across all ages?

Shin, Ji-Hyeon; Lee, Dong-Hee

doi:10.1002/alr.21942

Cited by 9 publications

(5 citation statements)

References 22 publications

(34 reference statements)

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“…Secondly, we showed that mite IgE sensitivity (SPT or specific IgE) decreased with age, as repeatedly reported [ 28 , 29 , 30 , 31 ]. In 2011, Scichilone and colleagues reviewed the available literature assessing the impact of age on atopy: the majority of the studies (i.e., 15 among 17) reported a decline of the prevalence of atopy with aging, associated with the immunosenescence process, in both healthy subjects and individuals affected by allergic respiratory diseases [ 31 ].…”

Section: Discussionsupporting

confidence: 84%

A Proposal to Differentiate ACO, Asthma and COPD in Vietnam

Chu

Nguyen

Godin

et al. 2022

JPM

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Background: In low- and middle-income countries, such as Vietnam, the population is exposed to multiple risks, leading to frequent allergic asthma, COPD and their overlap (ACO). We aimed to differentiate asthma and COPD, so that recommended treatments can be applied. Methods: We hypothesized that during life, the cumulative exposure to noxious particles increases the relative prevalence of COPD, while due to immuno-senescence, the prevalence of allergic asthma decreases with age. Among 568 patients with chronic respiratory symptoms, five phenotypes were defined, based on responsiveness to a bronchodilator (BD), diffusion capacity and cumulative smoking. Then the relative prevalence of each phenotype was related with age. Results: the smoker BD irreversible patients were considered “COPD”, while the full BD responders and non-smoking BD incomplete responders were “asthmatics”. The other patients were ACO, distributed as “like-COPD” or “like-asthma”, based on decreased or normal diffusion capacity. The relative prevalence of asthma, COPD and ACO were 26, 42 and 32% (18% “like-asthma”, 14% “like-COPD”). Conclusion: Vietnamese patients with chronic respiratory symptoms were considered as falling into asthma or COPD groups, based on cumulative smoking, spirometry with reversibility and diffusion capacity. The relative prevalence of asthma and COPD were 44 and 56%, respectively, most of which did not require corticosteroids.

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Section: Discussionsupporting

confidence: 84%

A Proposal to Differentiate ACO, Asthma and COPD in Vietnam

Chu

Nguyen

Godin

et al. 2022

JPM

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“…The mechanism of IgE sensitization to aeroallergens can change depending on the patient’s age. 39 Unlike JCP, HDM and animal dander sensitizations are prominent in children, 40 and HDM tends to not become a newly sensitized antigen as a person grows to adulthood. 39 , 40 In addition, once HDM-specific IgE responses increase in childhood, it is difficult for decreases to occur.…”

Section: Discussionmentioning

confidence: 99%

“…39 Unlike JCP, HDM and animal dander sensitizations are prominent in children, 40 and HDM tends to not become a newly sensitized antigen as a person grows to adulthood. 39 , 40 In addition, once HDM-specific IgE responses increase in childhood, it is difficult for decreases to occur. 41 Therefore, adulthood HDM and animal dander-specific IgEs do not necessarily indicate accurately sensitizations in adulthood and it was difficult to draw a clear conclusion from the results of this study.…”

Section: Discussionmentioning

confidence: 99%

Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children’s Study

Tsuji

Koriyama

Ishihara

et al. 2019

Journal of Epidemiology

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BackgroundMetal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children.MethodsWe investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children’s Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second/third trimester. Concentrations of the metals Cd, Pb, Hg, Se, and Mn, as well as serum total and allergen-specific IgEs for egg white, house dust-mites (HDM), Japanese cedar pollen (JCP), animal dander, and moth, were measured. Allergen-specific IgE(s) were divided based on concentrations <0.35 or ≥0.35 UA/mL, and the metal levels were divided into quartiles.ResultsMultivariable logistic regression analysis showed that there was a significant negative correlation between HDM- and animal dander-specific IgEs and Hg and Mn concentrations. Conversely, there was a significant positive relationship between JCP-specific IgE and Hg and Se concentrations.ConclusionsMetal exposures may be related to both increases and decreases in allergen-specific IgEs in pregnant women.

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“…For this reason, the precise and accurate detection of allergens is important for treating (immunotherapy) and preventing (allergen avoidance) atopic diseases. Several studies have reported that inhalant allergen sensitization can be affected by various factors, including genetics, age, exposure time, concentration of allergens, and other unknown factors [1][2][3][4][5][6][7]. Addition-ally, recent global shifts in climate might significantly affect the incidence of atopic diseases.…”

Section: Introductionmentioning

confidence: 99%

Cluster Analysis of Inhalant Allergens in South Korea: A Computational Model of Allergic Sensitization

Kim

Park

Joon

et al. 2021

Clin Exp Otorhinolaryngol

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Objectives. Sensitization to specific inhalant allergens is a major risk factor for the development of atopic diseases, which impose a major socioeconomic burden and significantly diminish quality of life. However, patterns of inhalant allergic sensitization have yet to be precisely described. Therefore, to enhance the understanding of aeroallergens, we performed a cluster analysis of inhalant allergic sensitization using a computational model. Methods. Skin prick data were collected from 7,504 individuals. A positive skin prick response was defined as an allergento-histamine wheal ratio ≥1. To identify the clustering of inhalant allergic sensitization, we performed computational analysis using the four-parameter unified-Richards model. Results. Hierarchical cluster analysis grouped inhalant allergens into three clusters based on the Davies-Bouldin index (0.528): cluster 1 (Dermatophagoides pteronyssinus and Dermatophagoides farinae), cluster 2 (mugwort, cockroach, oak, birch, cat, and dog), and cluster 3 (Alternaria tenus, ragweed, Candida albicans, Kentucky grass, and meadow grass). Computational modeling revealed that each allergen cluster had a different trajectory over the lifespan. Cluster 1 showed a high level (>50%) of sensitization at an early age (before 19 years), followed by a sharp decrease in sensitization. Cluster 2 showed a moderate level (10%-20%) of sensitization before 29 years of age, followed by a steady decrease in sensitization. However, cluster 3 revealed a low level (<10%) of sensitization at all ages. Conclusion. Computational modeling suggests that allergic sensitization consists of three clusters with distinct patterns at different ages. The results of this study will be helpful to allergists in managing patients with atopic diseases.

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How does the pattern of aeroallergen sensitization change over time across all ages?

Abstract: IgE sensitization to aeroallergens can change in individuals with allergy. These changes may be different according to the patient's age. If rhinitis symptoms or treatment efficacy changes, repeat IgE sensitization testing is needed to find changes in allergen sensitization patterns.

Cited by 9 publications

References 22 publications

A Proposal to Differentiate ACO, Asthma and COPD in Vietnam

A Proposal to Differentiate ACO, Asthma and COPD in Vietnam

Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children’s Study

Cluster Analysis of Inhalant Allergens in South Korea: A Computational Model of Allergic Sensitization

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