How Does <i>Phytophthora infestans</i> Evade Control Efforts? Modern Insight Into the Late Blight Disease

Leesutthiphonchai, Wiphawee; Vu, A. L.; Ah‐Fong, Audrey M. V.; Judelson, Howard S.

doi:10.1094/phyto-04-18-0130-ia

Cited by 101 publications

(85 citation statements)

References 85 publications

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“…Oomycete apoplastic effectors include a large number of hydrolytic enzymes, which are involved in the degradation of host cell components, enabling penetration of host cells [31]. Apoplastic effectors act at the extracellular side by inhibiting the activity of antifungal enzymes, such as proteases and 1,3-glucanases, produced by the plant [32] or can be translocated inside the host cell, through a poorly understood mechanism [33], that can be mediated by haustoria as in the case of EPIC1 in Phytophthora infestans (Mont.) de Bary [34].…”

Section: Introductionmentioning

confidence: 99%

Novel Aspects on The Interaction Between Grapevine and Plasmopara viticola: Dual-RNA-Seq Analysis Highlights Gene Expression Dynamics in The Pathogen and The Plant During The Battle For Infection

Toffolatti

Lorenzis

Brilli

et al. 2020

Genes

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Mgaloblishvili, a Vitis vinifera cultivar, exhibits unique resistance traits against Plasmopara viticola, the downy mildew agent. This offers the unique opportunity of exploring the molecular responses in compatible and incompatible plant-pathogen interaction. In this study, whole transcriptomes of Mgaloblishvili, Pinot noir (a V. vinifera susceptible cultivar), and Bianca (a resistant hybrid) leaves, inoculated and non-inoculated with the pathogen, were used to identify P. viticola effector-encoding genes and plant susceptibility/resistance genes. Multiple effector-encoding genes were identified in P. viticola transcriptome, with remarkable expression differences in relation to the inoculated grapevine cultivar. Intriguingly, five apoplastic effectors specifically associated with resistance in V. vinifera. Gene coexpression network analysis identified specific modules and metabolic changes occurring during infection in the three grapevine cultivars. Analysis of these data allowed, for the first time, the detection in V. vinifera of a putative P. viticola susceptibility gene, encoding a LOB domain-containing protein. Finally, the de novo assembly of Mgaloblishvili, Pinot noir, and Bianca transcriptomes and their comparison highlighted novel candidate genes that might be at the basis of the resistant phenotype. These results open the way to functional analysis studies and to new perspectives in molecular breeding of grapevine for resistance to P. viticola.

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Section: Introductionmentioning

confidence: 99%

Novel Aspects on The Interaction Between Grapevine and Plasmopara viticola: Dual-RNA-Seq Analysis Highlights Gene Expression Dynamics in The Pathogen and The Plant During The Battle For Infection

Toffolatti

Lorenzis

Brilli

et al. 2020

Genes

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“…Plant diseases caused by oomycetes are a primary problem for agriculture in the world [ 1 ]. Late blight disease is one of the most important and dangerous potato and tomato diseases with the potential for practical annihilation of potato plants [ 2 , 3 ]. The pathogen affects plants in damp conditions and causes necrosis of the leaves and rapid tuber decomposition [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Peptide Extracts from Seven Medicinal Plants Discovered to Inhibit Oomycete Phytophthora infestans, a Causative Agent of Potato Late Blight Disease

Рогожин

Vasilchenko

Barashkova

et al. 2020

Plants

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We report the inhibitory effect of peptide extracts obtained from seven medicinal plants against a causative agent of late blight disease Phytophthora infestans. We find that all the extracts possess inhibitory activity toward the zoospores output, zoosporangium germination, and the development of P. infestans on potato disc tubers at different quantitative levels. Based on the biological effects detected, an extract of common horsetail (Equisetum arvense) biomass is recognized as the most effective and is selected for further structural analysis. We perform a combination of amino acid analysis and MALDI-TOF mass spectrometry, which reveal the presence of Asn/Asp- and Gln/Glu-rich short peptides with molecular masses in the range of 500–900 Da and not exceeding 1500 Da as the maximum. Analytical anion-exchange HPLC is successfully applied for separation of the peptide extract from common horsetail (E. arvense). We collect nine dominant components that are combined in two groups with differences in retention times. The N-terminal amino acid sequence of the prevalent compounds after analytical ion-exchange HPLC allows us to identify them as peptide fragments of functionally active proteins associated with photosynthesis, aquatic transport, and chitin binding. The anti-oomycete effects may be associated with the conversion of ribulose-1,5-bisphosphate carboxylase/oxygenase to produce a number of biologically active anionic peptides with possible regulatory functions. These data inform our knowledge regarding biologically active peptide fragments; they are the components of programmed or induced proteolysis of plant proteins and can realize secondary antimicrobial functions.

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“…P. infestans can easily overcome control strategies including host resistance and fungicides. Its lifestyle helps it to evade plant defenses, effectors that suppress host defenses and promote susceptibility, profuse sporulation with a short latent period that enables rapid dissemination, and a genome structure that promotes the adaptive evolution by fostering genetic diversity (Leesutthiphonchai et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Migration and Selection Enforced Multiple Phenotypic and Genotypic Changes in the Population of <em>Phytophthora infestans</em> in Israel during the Last 36-Year Period

Cohen¹,

Ae²,

Gal'perin³

et al. 2020

Preprint

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Late blight caused by the oomycete pathogen Phytophthora infestans is a devastating disease of potato and tomato worldwide, including Israel. The population structure of this pathogen was monitored in potato and tomato fields in Israel during a 36-year period of 1983-2019. Isolates of the pathogen were tested for sensitivity to phenylamide fungicides, mating type, race structure, and genotype. The phenotypic and genotypic structure of the population from potato have changed greatly from one year to another, from one season to the next, within a season and within a single field. Major changes also occurred in the population collected from tomato crops. The mechanisms driving these multiple changes and the heterogeneous nature of the population in Israel are shown to derive from multiple migration events of the pathogen via seed tubers from Europe and from fitness-driven selection processes.

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How Does Phytophthora infestans Evade Control Efforts? Modern Insight Into the Late Blight Disease

Cited by 101 publications

References 85 publications

Novel Aspects on The Interaction Between Grapevine and Plasmopara viticola: Dual-RNA-Seq Analysis Highlights Gene Expression Dynamics in The Pathogen and The Plant During The Battle For Infection

Novel Aspects on The Interaction Between Grapevine and Plasmopara viticola: Dual-RNA-Seq Analysis Highlights Gene Expression Dynamics in The Pathogen and The Plant During The Battle For Infection

Peptide Extracts from Seven Medicinal Plants Discovered to Inhibit Oomycete Phytophthora infestans, a Causative Agent of Potato Late Blight Disease

Migration and Selection Enforced Multiple Phenotypic and Genotypic Changes in the Population of <em>Phytophthora infestans</em> in Israel during the Last 36-Year Period

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