How does brain activation differ in children with unilateral cerebral palsy compared to typically developing children, during active and passive movements, and tactile stimulation? An fMRI study

Winckel, Ann Van de; Klingels, Katrijn; Bruyninckx, Frans; Wenderoth, Nicole; Peeters, Ron; Sunaert, Stefan; Hecke, Wim Van; Cock, Paul De; Eyssen, M; Weerdt, Willy De; Feys, Hilde

doi:10.1016/j.ridd.2012.07.030

Cited by 63 publications

(71 citation statements)

References 44 publications

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“…Patients with hemiplegic CP often help their affected limb while performing daily tasks by compensatory use of their unaffected limb. 4,5 Even though CP cannot be cured, motor control skills in these children can be improved through repetitive task-specific treatments targeting an increased involvement of the affected limb. 6 Constraint-induced movement therapy (CIMT) is one such common treatment for children with upper limb hemiplegia.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy

et al. 2015

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Abstract. Sensorimotor cortex plasticity induced by constraint-induced movement therapy (CIMT) in six children (10.2 AE 2.1 years old) with hemiplegic cerebral palsy was assessed by functional near-infrared spectroscopy (fNIRS). The activation laterality index and time-to-peak/duration during a finger-tapping task and the resting-state functional connectivity were quantified before, immediately after, and 6 months after CIMT. These fNIRS-based metrics were used to help explain changes in clinical scores of manual performance obtained concurrently with imaging time points. Five age-matched healthy children (9.8 AE 1.3 years old) were also imaged to provide comparative activation metrics for normal controls. Interestingly, the activation time-to-peak/duration for all sensorimotor centers displayed significant normalization immediately after CIMT that persisted 6 months later. In contrast to this improved localized activation response, the laterality index and resting-state connectivity metrics that depended on communication between sensorimotor centers improved immediately after CIMT, but relapsed 6 months later. In addition, for the subjects measured in this work, there was either a trade-off between improving unimanual versus bimanual performance when sensorimotor activation patterns normalized after CIMT, or an improvement occurred in both unimanual and bimanual performance but at the cost of very abnormal plastic changes in sensorimotor activity. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Introductionmentioning

confidence: 99%

Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy

et al. 2015

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“…Bilateral activation in sensorimotor areas is common in children with CP, but is not seen in all cases as activation patterns are variable in this population. 29,30 Interestingly, in the mirror hand image [ Fig. 5(b)], the ipsilateral M1/S1 and contralateral PMC showed weak levels of activation consistent with the relatively sparse and low-amplitude mirror hand muscle activations.…”

Section: Identification Of Brain Activation Areas Due To Tapping and mentioning

confidence: 64%

“…2 Sensorimotor activation patterns of the brain in children with CP have been mapped by functional magnetic resonance imaging (fMRI) in several recent studies. [3][4][5][6] However, fMRI requires subjects to remain still for extended periods of time in a restricted space, which is particularly difficult to do when working with children with CP. Recently, functional near-infrared spectroscopy (fNIRS) has been demonstrated as a feasible alternate neuroimaging technique that enables brain activation measurements under relatively unrestricted conditions.…”

Section: Introductionmentioning

confidence: 99%

Motion tracking and electromyography-assisted identification of mirror hand contributions to functional near-infrared spectroscopy images acquired during a finger-tapping task performed by children with cerebral palsy

et al. 2014

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Abstract. Recent studies have demonstrated functional near-infrared spectroscopy (fNIRS) to be a viable and sensitive method for imaging sensorimotor cortex activity in children with cerebral palsy (CP). However, during unilateral finger tapping, children with CP often exhibit unintended motions in the nontapping hand, known as mirror motions, which confuse the interpretation of resulting fNIRS images. This work presents a method for separating some of the mirror motion contributions to fNIRS images and demonstrates its application to fNIRS data from four children with CP performing a finger-tapping task with mirror motions. Finger motion and arm muscle activity were measured simultaneously with fNIRS signals using motion tracking and electromyography (EMG), respectively. Subsequently, subject-specific regressors were created from the motion capture or EMG data and independent component analysis was combined with a general linear model to create an fNIRS image representing activation due to the tapping hand and one image representing activation due to the mirror hand. The proposed method can provide information on how mirror motions contribute to fNIRS images, and in some cases, it helps remove mirror motion contamination from the tapping hand activation images.

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“…Functional MRI (fMRI) studies have provided insight into reorganisation and lateralisation of motor regions in children with UCP 129 , with increased bilateral activation of sensorimotor cortex compared with unilateral activation in controls 130 .…”

Section: Discussionmentioning

confidence: 99%

Motor, sensory and executive function brain networks in children with unilateral cerebral palsy

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How does brain activation differ in children with unilateral cerebral palsy compared to typically developing children, during active and passive movements, and tactile stimulation? An fMRI study

Cited by 63 publications

References 44 publications

Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy

Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy

Motion tracking and electromyography-assisted identification of mirror hand contributions to functional near-infrared spectroscopy images acquired during a finger-tapping task performed by children with cerebral palsy

Motor, sensory and executive function brain networks in children with unilateral cerebral palsy

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