How do we define therapy-resistant constipation in children aged 4–18 years old? A systematic review with meta-narrative synthesis
Vassiliki Sinopoulou,
Morris Gordon,
Shaman Rajindrajith
et al.
Abstract:BackgroundTherapy-resistant constipation often is a frustrating clinical entity recognised by the persistence of infrequent and painful bowel movements faecal incontinence and abdominal pain despite intensive treatment. It is important to clearly define therapy-resistant constipation before children are subjected to invasive diagnostic and therapeutic procedures.AimTo conduct a systematic review determining how paediatric interventional studies define therapy-resistant constipation.MethodWe searched CENTRAL, M… Show more
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