How do vertebroplasty and kyphoplasty affect the quality of life of patients with multiple myeloma spinal metastasis?

Tekin, Sezgin Bahadır; Karslı, Burçin; Buyukbebeci, Orhan; Demir, İbrahim; Gökalp, Alp Yekta; Kılınçoğlu, Volkan

doi:10.1007/s00590-020-02721-3

Cited by 11 publications

(8 citation statements)

References 20 publications

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“…Since PVP was reported in 1987, it has been widely used in OVFs and pathological fractures caused by metastases, myeloma and hemangioma (5,(13)(14)(15). When the bone cement is injected into the fractured vertebral body, the pain can be quickly relieved and the strength and stiffness of the vertebral body can be restored.…”

Section: Discussionmentioning

confidence: 99%

Safety and prognosis of repeated vertebroplasty in the treatment of osteoporotic vertebral fractures

Zou

Qiu

Jin

et al. 2022

Preprint

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Purpose The number of patients with re-fracture after vertebral augmentation has gradually increased. Usually, these patients are re-treated with vertebral augmentation, but less attention has been paid to the safety and prognosis of repeated and multi-level treatment with percutaneous vertebroplasty(PVP). This study aims to retrospectively analyze the safety and prognosis of repeated PVP in the treatment of patients with osteoporotic vertebral fractures (OVFs), and to further analyze the factors affecting their prognosis. Methods A retrospective analysis of 61 patients with re-fractures after vertebral augmentation who received PVP treatment again from January 2019 to December 2021. The patients were divided into pain group and pain-free group according to their back pain status at last follow-up. The following covariates were reviewed: Age, bone mineral density(BMD), bone cement dosage, bone cement leakage, body mass index (BMI); and the rate of anterior vertebral height(AVH) loss in the target before surgery, 1 week after surgery and at last follow-up. The patients were assessed using Visual analogue scale score (VAS), Oswestry Disability Index (ODI). Results A total of 61 patients were included, 17 in the pain group and 44 in the pain-free group. Binary logistic regression analysis revealed the rate of AVH loss at 1 week postoperatively and last follow-up was associated with postoperative back pain. According to the ROC curve analysis, the area under the curvature(AUC) of the AVH loss rate at 1 week after operation was 0.6845, and the cut-off value was 0.18; the AUC of the AVH loss rate at the last follow-up was 0.7306, and the cut-off value was 0.2815. Further Kaplan-Meier survival analysis showed that patients with lower AVH loss rates had lower incidence of postoperative back pain and better prognosis. Conclusion PVP is safe and effective in the short term for patients with re-fracture after vertebral augmentation. Postoperative back pain was strongly associated with AVH loss at 1 week postoperatively and at last follow-up. Patients with a lower rate of AVH loss had a lower incidence of postoperative back pain and a better prognosis.

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Section: Discussionmentioning

confidence: 99%

Safety and prognosis of repeated vertebroplasty in the treatment of osteoporotic vertebral fractures

Zou

Qiu

Jin

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Patients with spinal metastases are highly likely to achieve significant improvements in pain control and reduced pain-related disability through minimally-invasive surgery (33)(34)(35). Previous reports published on minimally invasive surgery in spinal metastasis were largely focused on osteolytic metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…Previous reports published on minimally invasive surgery in spinal metastasis were largely focused on osteolytic metastasis. Improvements in preoperative definable vertebral collapse ( 36 ) and postoperative pain relief and QOL were demonstrated ( 33 ). Both PVP and PKP are effective, and no difference could be found in their relative effectiveness ( 37 , 38 ).…”

Section: Discussionmentioning

confidence: 99%

“…Both PVP and PKP are effective, and no difference could be found in their relative effectiveness ( 37 , 38 ). PVP could achieve pain relief and improvement of life quality of patients with multiple myeloma spinal metastasis ( 33 ). Concerning the subsequent cost dure to the care requirements and serious clinical consequences of spinal metastasis, the use of PVP could be a cost-effective strategy at commonly accepted willingness-to-pay thresholds ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

“…For patients with advanced cancer who have developed bone metastases, increased life expectancy has made metastases more observable, which has resulted in a change in treatment strategy from curative to palliative ( 33 ). Minimally invasive procedures performed after spinal metastases, including vertebroplasty and kyphoplasty, could significantly improve the patient's QOL ( 33 ). Questionnaires for this group of patients should be brief while still including the most important QOL issues so as not to burden the patient ( 45 ).…”

Section: Discussionmentioning

confidence: 99%

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