How Do ROS Induce NETosis? Oxidative DNA Damage, DNA Repair, and Chromatin Decondensation
Dhia Azzouz,
Nades Palaniyar
Abstract:Neutrophil extracellular traps (NETs) are intricate, DNA-based, web-like structures adorned with cytotoxic proteins. They play a crucial role in antimicrobial defense but are also implicated in autoimmune diseases and tissue injury. The process of NET formation, known as NETosis, is a regulated cell death mechanism that involves the release of these structures and is unique to neutrophils. NETosis is heavily dependent on the production of reactive oxygen species (ROS), which can be generated either through NAD… Show more
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