How do morphological changes of caffeine hydrate influence caking

Cui, Pingping; Liu, Yinggui; Zhou, Ling; Yin, Qiuxiang

doi:10.1016/j.jfoodeng.2022.111393

Cited by 1 publication

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, a theoretical characterization of caffeine Raman features has only been carried out on a molecular scale simulating the chemical fingerprint (i.e., MFR domain) . The intrinsic high structural disorder of caffeine solid-state forms ,, has so far limited an accurate emulation of the lattice vibrations that require the use of definite periodic boundary conditions.…”

Section: Resultsmentioning

confidence: 99%

In Situ Imaging of Subcutaneous Drug Delivery Systems Using Microspatially Offset Low-Frequency Raman Spectroscopy

Be̅rziņš,

Czyrski,

Aljabbari

et al. 2024

Anal. Chem.

View full text Add to dashboard Cite

The noninvasive in situ monitoring of the status of drug retention and implant integrity of subcutaneous implants would allow optimization of therapy and avoid periods of subtherapeutic delivery kinetics. A proof-of principle study was conducted to determine the use of microspatially offset low-frequency Raman spectroscopy (micro-SOLFRS) for nonintrusive in situ analysis of subcutaneous drug delivery systems. Caffeine was used as the model drug, and it was embedded in a circular-shape Soluplus matrix via vacuum compression molding. For the exploratory analysis, prototype implants were positioned underneath skin tissue samples, and various caffeine concentrations (1−50% w/w) and micro-SOLFRS displacement settings (Δz = 0−8 mm) were tested from the pseudo three-dimensional (3D)-imaging perspective. This format allowed the optimization of real-time micro-SOLFRS analysis of implants through skin tissue that was embedded in an agarose hydrogel. Notably, this analytical approach allowed the temporal and spatial erosion of the implant and solid-state transformations of caffeine to be distinguished. The spectrometric results correlated with complementary high-performance liquid chromatography (HPLC) determination of changes in drug concentration, illustrating drug dissipation/diffusion characteristics. The discovered capability of micro-SOLFRS for in situ measurements of drugs and implants makes it attractive for biomedical diagnostics that, ultimately, could result in development of a new point-of-care technology.

show abstract