How do cumulative live birth rates and cumulative multiple live birth rates over complete courses of assisted reproductive technology treatment per woman compare among registries?

Neubourg, Diane De; Bogaerts, Kris; Blockeel, Christophe; Coetsier, Tom; Delvigne, Annick; Devreker, Fabienne; Dubois, Michel; Gillain, Nicolas; Gordts, Stephan; Wyns, Christine

doi:10.1093/humrep/dev270

Cited by 51 publications

(38 citation statements)

References 11 publications

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“…The CLBRs for the conservative and optimal estimates (51% and 72%) after six complete cycles reported by Malizia et al from a large center in Boston were lower than these in our study (64.34% and 83.40%) [2]. Comparing with the conservative and optimal estimates of CLBRs after six complete cycles in the UK (43.90% and 75.50%) and Belgium (54.10% and 76.30), corresponding gures from our research were slightly higher [5,17]. We speculate that the higher CLBRs in our study is related with our treatment protocol-freeze all strategy, which has been reported that could increase pregnancy rate and live birth rate by avoiding the potential deleterious effects of controlled ovarian stimulation on the endometrium.…”

Section: Discussioncontrasting

confidence: 73%

“…A prospective study conducting among 156947 UK women between 2003 and 2010 showed six cycles achieved CLBRs of 78.0% and 46.8% for the optimal and conservative estimates, respectively [4]. A retrospective study included 12869 patients who were registered in the Belgian national assisted reproductive technology (ART) registry between 2009 and 2011 revealed the optimal and conservative estimates of CLBRs after six cycles were 76.3% and 54.1% [5]. However, these studies were all about conventional IVF strategy, the CLBRs following freeze-all strategy has not been reported.…”

Section: Introductionmentioning

confidence: 99%

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Cumulative live birth rates over multiple complete cycles of in vitro fertilisation cycles: ten-year cohort study of 20687 women following freeze-all strategy

Zhu¹,

Wang²,

J³

et al. 2020

Preprint

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Background For patients embarking on in vitro fertilization (IVF) or Intracytoplasmic sperm injection (ICSI), one of the most concerned problems is their chance of a live-birth. The cumulative live birth rate (CLBR) after IVF has been reported in recent years; however these studies were all about conventional IVF strategy, the CLBRs following freeze-all strategy has not been reported. Methods This was a retrospective cohort study. A total of 20687 women undergoing their first and following IVF cycles during the period from January 1, 2007 through March 31, 2016 were included in this study. The primary Outcomes of the present study were presented in three types: the live birth rate per complete cycle, the conservative CLBR and the optimal CLBR. Results The CLBR increased from 50.74% for the first complete cycle to 64.41% after seven complete cycles,and varied by age category. The CLBR after five complete cycles declined from 77.11% for women younger than 31 years, to 8.63% for women older than 40 years. The predictors of live birth over multiple complete cycles for patients embarking on IVF following freeze-all strategy were women’s age and causes of infertility. In the model constructed for patients finishing the first complete cycle, the number of oocyte retrieved at complete cycle one also played an important predictive role. Conclusions Among women undergoing IVF following freeze-all strategy, the CLBR after seven complete IVF cycles was 84.77% if there were no barriers to continue the IVF treatment, with variation by age. Two prediction models were developed to estimate their probability of having a baby over multiple complete IVF cycles with freeze-all strategy among patients before starting IVF and patients after the first complete cycle, which is critical for patients to make treatment decisions and preparations physically, emotionally and financially.

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Section: Discussioncontrasting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Cumulative live birth rates over multiple complete cycles of in vitro fertilisation cycles: ten-year cohort study of 20687 women following freeze-all strategy

Zhu¹,

Wang²,

J³

et al. 2020

Preprint

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“…Chance is affected by a range of treatment‐related and individual factors. If there are embryos available for freezing after a stimulated cycle this increases the chance of having a baby because they can be transferred one by one in subsequent cycles if there is no pregnancy . Almost half of the embryo transfers undertaken in Australia and New Zealand in 2014 were of thawed embryos .…”

Section: Introductionmentioning

confidence: 99%

“…To avoid these, almost all embryo transfers (83%) performed in Australia and New Zealand in 2014 were single embryo transfers . For those who do not achieve a live birth in their first stimulated cycle, each additional cycle they undergo, at least up to six cycles, increases the chance of this happening . Of the individual factors that influence chance of success, the woman's age is the most significant.…”

Section: Introductionmentioning

confidence: 99%

Quality of information about success rates provided on assisted reproductive technology clinic websites in Australia and New Zealand

Hammarberg¹,

Prentice²,

Purcell³

et al. 2017

Aust NZ J Obst Gynaeco

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“…Because of our strict policy of single embryo transfer (sET) multiple pregnancy rate in our series was low and completely comparable to the corresponding fi gure aft er NR. It was demonstrated that the sET policy resulted in a signifi cant reduction in the multiple pregnancy rate from 24% to 12% in Belgium [22] without a negative impact on the cumulative pregnancy rate [23,24].…”

Section: One Of the Sources Of Perinatal Complications (Especiallymentioning

confidence: 99%

Obstetrical and Perinatal Complications after Assisted Reproduction: what matters is age, not the procedure

Barrenetxea¹

2020

RIJOG

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Background: Worldwide, an increasing number of children (1 out of 10 in some countries) are born to pregnancies achieved by applying assisted reproductive technology (ART). It has been assumed that these pregnancies have a higher prevalence of both obstetric and neonatal complications compared to gestations achieved after natural reproduction (NR). Objective: The purpose of this study was to evaluate and compare maternal obstetrical and perinatal complications between pregnancies achieved after ART and NP, in a setting in which a strict policy of single embryo transfer is followed. Study design: This is an observational comparative study to assess obstetrical and perinatal outcomes involving 583 patients who achieved an ongoing pregnancy after ART, by using either autologous (AO) (363 women) or donated oocytes (DO) (220 women) at a University associated Assisted Reproduction Center, between January, 2016 and December, 2018. Age of women at delivery, gestational length, type of delivery, birthweight of newborns and perinatal complications were registered and compared to 273 deliveries of pregnant women after NP clinically followed at our center. Results: Due to strict single embryo transfer policy the rate of multiple pregnancies after ART (1,38%) was comparable to that of gestations after NR (1,10%) (OR: 1,25; 95% CI 0,33-4,76). In our series, the percentage of women aged 35 or older (AMA) and 40 and older (VAMA), was similar between women in the NR group (59,34% and 17,22%) and those of the ART with autologous oocytes (AO) group (57,85% and 13,77%) (p=0,759 and p=0,234). Age of women was signi icantly higher in women pregnant after ART-DO procedures. The rate of preterm deliveries was 6,59%, 3,58% and 12,27% for NR, ART-AO and ART-DO respectively. Birthweight of neonates after ART-AO was signi icantly higher than after NR (p=0,000) and after ART-DO (p=0,000).

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How do cumulative live birth rates and cumulative multiple live birth rates over complete courses of assisted reproductive technology treatment per woman compare among registries?

Abstract: none.

Cited by 51 publications

References 11 publications

Cumulative live birth rates over multiple complete cycles of in vitro fertilisation cycles: ten-year cohort study of 20687 women following freeze-all strategy

Cumulative live birth rates over multiple complete cycles of in vitro fertilisation cycles: ten-year cohort study of 20687 women following freeze-all strategy

Quality of information about success rates provided on assisted reproductive technology clinic websites in Australia and New Zealand

Obstetrical and Perinatal Complications after Assisted Reproduction: what matters is age, not the procedure

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