How do basic secretagogues activate mast cells?

Seifert, Roland

doi:10.1007/s00210-015-1093-6

Cited by 9 publications

(16 citation statements)

References 24 publications

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“…Voltage-dependent Ca 2+ -influx channels are absent from plants, as are IP 3 Rand RyR-type CRCs. These are present in ciliates as well as in unikonts up to mammals (Plattner & Verkhratsky, 2012, 2015.…”

Section: Discussionmentioning

confidence: 99%

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Signalling in ciliates: long- and short-range signals and molecular determinants for cellular dynamics

Plattner

2015

Biol Rev

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In ciliates, unicellular representatives of the bikont branch of evolution, inter- and intracellular signalling pathways have been analysed mainly in Paramecium tetraurelia, Paramecium multimicronucleatum and Tetrahymena thermophila and in part also in Euplotes raikovi. Electrophysiology of ciliary activity in Paramecium spp. is a most successful example. Established signalling mechanisms include plasmalemmal ion channels, recently established intracellular Ca -release channels, as well as signalling by cyclic nucleotides and Ca . Ca -binding proteins (calmodulin, centrin) and Ca -activated enzymes (kinases, phosphatases) are involved. Many organelles are endowed with specific molecules cooperating in signalling for intracellular transport and targeted delivery. Among them are recently specified soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), monomeric GTPases, H -ATPase/pump, actin, etc. Little specification is available for some key signal transducers including mechanosensitive Ca -channels, exocyst complexes and Ca -sensor proteins for vesicle-vesicle/membrane interactions. The existence of heterotrimeric G-proteins and of G-protein-coupled receptors is still under considerable debate. Serine/threonine kinases dominate by far over tyrosine kinases (some predicted by phosphoproteomic analyses). Besides short-range signalling, long-range signalling also exists, e.g. as firmly installed microtubular transport rails within epigenetically determined patterns, thus facilitating targeted vesicle delivery. By envisaging widely different phenomena of signalling and subcellular dynamics, it will be shown (i) that important pathways of signalling and cellular dynamics are established already in ciliates, (ii) that some mechanisms diverge from higher eukaryotes and (iii) that considerable uncertainties still exist about some essential aspects of signalling.

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Section: Discussionmentioning

confidence: 99%

“…For some proteins common precursor molecules are likely to occur in protozoa, e.g. InsP 3 -and RyRs in ciliates (Plattner & Verkhratsky, 2012, 2015, whose descendants may have further differentiated in unikonts and been lost in plants. A strict separation of the two lineages on the basis of signalling is not possible.…”

Section: Discussionmentioning

confidence: 99%

Signalling in ciliates: long- and short-range signals and molecular determinants for cellular dynamics

Plattner

2015

Biol Rev

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“…Alternatively, muscarinic agonists may stimulate the Gαq/11 subunits of the acetylcholine GPCRs 43 . So-called pseudoallergic agents also follow this route 77 . All individuals can respond via GPCR receptors to the stimulus of the agonist, but only sensitized individuals (the "truly" allergic) can respond via IgE/FcεRI.…”

Section: Physio-pathological Effects Of Cellular Acidification In Epimentioning

confidence: 99%

Acids Can Promote the Onset and Multimorbidity of Allergic and Nonallergic Airway Diseases

Molinari¹,

Molinari²,

Nervo³

2019

Preprint

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Inflammatory allergic and nonallergic respiratory pathologies often co-exist. The root cause is not clear. This paper demonstrates that it is ascribable to protons (H+) released into cells by exogenous and endogenous acids. The hypothesis of acids as the common cause stems from two considerations: a) it has long been known that exogenous acids present in air pollutants can induce the irritation of epithelial surfaces, particularly the airways, inflammation and bronchospasm; b) according to recent articles, endogenous acids, generated in cells by phospholipases, play a key role in the biochemical mechanisms of initiation and progression of allergic responses. Therefore, the intracellular acidification and consequent Ca2+ increase, induced by protons generated by either acid pollutants or endogenous phospholipases, may be the causal mechanism of the multimorbidity of these diseases, and environmental acidity may contribute to their spread.

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confidence: 99%

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confidence: 99%

How do basic secretagogues activate mast cells?

Cited by 9 publications

References 24 publications

Signalling in ciliates: long- and short-range signals and molecular determinants for cellular dynamics

Signalling in ciliates: long- and short-range signals and molecular determinants for cellular dynamics

Acids Can Promote the Onset and Multimorbidity of Allergic and Nonallergic Airway Diseases

Naunyn-Schmiedeberg’s Archives of Pharmacology under new editorship: change and continuity

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