This study examined the influence of built environments on crashes with different levels of injury severity, and employed Geographically Weighted Negative Binomial Regressions to test whether these relationships varied across different neighborhoods in Austin, Texas. The results showed that high-speed roads produced more total and fatal crashes, and their influence was stronger in downtown areas than in peripheral regions. Commercial and office areas experienced more injury crashes, especially in downtown locations. It is crucial to implement programs to reduce vehicle travel demand, retrofit high-speed roads, and design land areas that generate fewer vehicle trips, especially for downtown spaces.