How Did the Omicron Surge Affect Kidney Transplant Recipients Compared With a Cohort From the General Population?

Cristelli, Marina Pontello; Rissoni, Renata Aparecida Pimentel; Viana, Laila Almeida; Tedesco‐Silva, Hélio; Medina‐Pestana, José Osmar

doi:10.1097/tp.0000000000004193

Cited by 13 publications

(15 citation statements)

References 5 publications

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“…[17–20] A study of 10,497 KT recipients in Brazil showed that the second wave of the Omicron-dominant outbreak (December 2021–March 2022) resulted in 50–70% fewer deaths than that in the first wave (March 2020–December 2021). [21] The mortality rate observed in our study was comparatively low, which may be attributed to either the specific subvariant of SARS-CoV-2, or the meticulous care provided. Notably, the four patients who died had a long history of KT, and were either vulnerable to coinfection or were of an advanced age.…”

Section: Discussionmentioning

confidence: 70%

Clinical Characteristics and Outcomes of Unvaccinated Kidney Transplant Recipients Infected with the SARS-CoV-2 Omicron Variant: A Case Series

Qu,

Zhuang,

Duan

et al. 2024

Integr Med Nephrol Androl

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Background: Due to their chronic immunocompromised status, kidney transplant (KT) recipients face escalated risks from coronavirus disease 2019 (COVID-19), which may be exacerbated by lower vaccination rates. However, there is a paucity of information regarding the clinical traits of unvaccinated KT recipients with COVID-19. We aimed to investigate the clinical characteristics and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron infection in unvaccinated KT recipients. Methods: In this retrospective study, we analyzed the clinical outcomes of 36 unvaccinated KT recipients diagnosed with SARS-CoV-2 Omicron infection, as confirmed by reverse transcription polymerase chain reaction. Clinical characteristics, laboratory tests, treatment regimens, and outcomes were examined, and 2-month follow-up assessments were conducted. Results: KT recipients had a high incidence of severe infection, with 66.7% classified as having severe/critical illness. Factors associated with severe/critical illness included age; diabetes mellitus; lung infection computed tomography score; and elevated serum D-dimer, interleukin-6, C-reactive protein, procalcitonin, and ferritin levels. The patients in the severe/critical group also had significantly lower blood lymphocyte counts and serum albumin levels. Treatment strategies included discontinuation of antimetabolic drugs, reduction or discontinuation of calcineurin inhibitor drugs, antiviral therapy, and early patient-tailored nutritional support. Acute kidney injury was observed in 19.4% of patients. Four (11.1%) patients died during the observation period, with two (5.6%) succumbing hospitalization and two (5.6%) during the 2-month follow-up period due to infection. The remaining patients did not report any significant symptoms and are still undergoing follow-up. Conclusion: Early diagnosis, personalized treatment, and vigilant monitoring are all crucial aspects of the clinical management of unvaccinated KT recipients with COVID-19. These findings contribute to the understanding of the clinical characteristics and management of COVID-19 in patients undergoing KT.

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Section: Discussionmentioning

confidence: 70%

Clinical Characteristics and Outcomes of Unvaccinated Kidney Transplant Recipients Infected with the SARS-CoV-2 Omicron Variant: A Case Series

Qu,

Zhuang,

Duan

et al. 2024

Integr Med Nephrol Androl

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“…Nesse grupo, a resposta humoral e celular à vacinação foi baixa, e a letalidade foi sustentada em mais de vinte e cinco por cento dos pacientes infectados, possivelmente associada ao uso crônico de drogas imunossupressoras 4,8 . A situação permaneceu inalterada independentemente da variante do vírus e do número ou origem das vacinas oferecidas, até o advento da variante omicron, quando a taxa de letalidade entre os pacientes transplantados renais caiu de 25% para 2% 9 .…”

Section: Transplantar Ou Não Transplantar Durante Uma Pandemia?unclassified

Transplantar ou não transplantar durante uma pandemia?

Medina-Pestana¹

2023

Braz. J. Nephrol.

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“…The comparator group consisted of healthy child volunteers from a city in the state of Sao Paulo that has acted as a comparator group since the beginning of the pandemic. 2 Patients were included if they had received the first dose and were able to receive the second dose, had no confirmed COVID-19 before the first dose, and had not received any other vaccine in the previous 4 wk. Significant adverse events and breakthrough infections were monitored for 6 mo following the second dose.…”

mentioning

confidence: 99%

Immunogenicity, Safety, and Clinical Effectiveness After 2 Doses of BNT162b2 Vaccine Among Pediatric Kidney Transplant Recipients Versus Healthy Volunteers: A Prospective Nonrandomized Study

et al. 2023

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How Did the Omicron Surge Affect Kidney Transplant Recipients Compared With a Cohort From the General Population?

Cited by 13 publications

References 5 publications

Clinical Characteristics and Outcomes of Unvaccinated Kidney Transplant Recipients Infected with the SARS-CoV-2 Omicron Variant: A Case Series

Clinical Characteristics and Outcomes of Unvaccinated Kidney Transplant Recipients Infected with the SARS-CoV-2 Omicron Variant: A Case Series

Transplantar ou não transplantar durante uma pandemia?

Immunogenicity, Safety, and Clinical Effectiveness After 2 Doses of BNT162b2 Vaccine Among Pediatric Kidney Transplant Recipients Versus Healthy Volunteers: A Prospective Nonrandomized Study

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