How common is fatigue in disease-free breast cancer survivors? A systematic review of the literature

Minton, Ollie; Stone, Patrick

doi:10.1007/s10549-007-9831-1

Cited by 164 publications

(119 citation statements)

References 43 publications

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“…FOR is triggered by antecedents such as physical symptoms or by perceived risk, resulting in psychological distress, 37,38 and contributes indirectly to fatigue. 39,40 Previous research has shown that MBSR(BC) reduces FOR and distal psychological and physical symptoms. 41 This is the only large clinical trial to our knowledge to examine and validate the effects of MBSR(BC) on FOR among BCSs unique showing immediate (6 weeks) and sustained (12 weeks) improvements for reducing FOR.…”

Section: Discussionmentioning

confidence: 99%

Examination of Broad Symptom Improvement Resulting From Mindfulness-Based Stress Reduction in Breast Cancer Survivors: A Randomized Controlled Trial

Lengacher

Reich

Paterson

et al. 2016

JCO

192

215

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The purpose of this randomized trial was to evaluate the efficacy of the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR [BC]) program in improving psychological and physical symptoms and quality of life among breast cancer survivors (BCSs) who completed treatment.Outcomes were assessed immediately after 6 weeks of MBSR(BC) training and 6 weeks later to test efficacy over an extended timeframe. Patients and MethodsA total of 322 BCSs were randomly assigned to either a 6-week MBSR(BC) program (n = 155) or a usual care group (n = 167). Psychological (depression, anxiety, stress, and fear of recurrence) and physical symptoms (fatigue and pain) and quality of life (as related to health) were assessed at baseline and at 6 and 12 weeks. Linear mixed models were used to assess MBSR(BC) effects over time, and participant characteristics at baseline were also tested as moderators of MBSR(BC) effects. ResultsResults demonstrated extended improvement for the MBSR(BC) group compared with usual care in both psychological symptoms of anxiety, fear of recurrence overall, and fear of recurrence problems and physical symptoms of fatigue severity and fatigue interference (P , .01). Overall effect sizes were largest for fear of recurrence problems (d = 0.35) and fatigue severity (d = 0.27). Moderation effects showed BCSs with the highest levels of stress at baseline experienced the greatest benefit from MBSR(BC). ConclusionThe MBSR(BC) program significantly improved a broad range of symptoms among BCSs up to 6 weeks after MBSR(BC) training, with generally small to moderate overall effect sizes.

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Section: Discussionmentioning

confidence: 99%

Examination of Broad Symptom Improvement Resulting From Mindfulness-Based Stress Reduction in Breast Cancer Survivors: A Randomized Controlled Trial

Lengacher

Reich

Paterson

et al. 2016

JCO

192

215

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“…It is also suggested that despite comparable rates of depression to those without a history of cancer, cancer survivors may experience greater impairment from major depressive disorder (MDD) compared to those without cancer [2]. Fatigue is also a common complaint among disease-free breast cancer survivors with good evidence of severe fatigue affecting women up to 5 years after completion of therapy [5]. Depression is a significant correlate of post-treatment fatigue, and significant psychological disorders should be excluded before patients are considered to have cancerrelated fatigue syndrome [6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of screening instruments for depression and anxiety in breast cancer survivors

Alexander

Palmer

Stone

2009

Breast Cancer Res Treat

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Although cases of anxiety and depression postbreast cancer can be reliably identified using a structured psychiatric interview, such interviews are time consuming for both practitioner and patient and effective screening tools would increase detection rates. The purpose of this study was to evaluate the effectiveness of the Edinburgh Depression Scale (EDS) and the Hospital Anxiety and Depression Scale (HADS) in screening for depression and anxiety in a population of breast cancer survivors. For this purpose, The Structured Clinical Interview for the Diagnostic and Statistical Manual of mental disorders was administered to 200 breast cancer survivors to identify those suffering from an anxiety and/or depressive disorder. All study participants also completed the EDS and the HADS. Using the recommended cut-off score of [12 to screen for depression, the sensitivity and specificity of the EDS were found to be 72 and 90%, respectively. Lowering the cut-off score to [9 resulted in a sensitivity of 94% and a specificity of 78%. At the recommended cut-off score of [10, the HADS had a sensitivity of 50% and a specificity of 97% for depression, and a sensitivity of 71% and a specificity of 86% when screening for anxiety. A HADS total score (HADS-T) of [13 and an EDS of [9 had sensitivities of 96 and 91% and specificities of 74 and 84%, respectively, in screening for anxiety and/or depression. In conclusion, the study demonstrated that both the EDS and HADS can be used reliably as screening tests for anxiety and depression in this cohort. In both cases, a lower cut-off score than normally recommended delivers optimal screening properties.

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“…A substantial proportion of breast cancer survivors experience fatigue (Minton & Stone, 2008;Reinertsen et al, 2010). Fatigue involves subjective sensations of tiredness, weakness, and/or lack of energy (J. E. Bower et al, 2006).…”

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confidence: 99%

Is Dispositional Optimism Associated with Fatigue in Breast Cancer Survivors?

Schou-Bredal¹,

Tøien²

2017

PSYCH

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In view of the large body of research demonstrating that optimism has beneficial effects on people's well-being and health, one may assume that it also protects against fatigue. However, few studies have investigated the association between optimism and cancer-related fatigue in cancer patients, and the results are inconsistent. Thus our aim was to investigate if optimism is associated with severe fatigue, when adjusting for known factors associated with fatigue such as age, emotional distress, pain, Body Mass Index (BMI), surgery type and adjuvant treatment. We conducted a nationwide survey of 832 Norwegian breast cancer survivors. The women completed the Fatigue Questionnaire, Brief Pain Inventory Questionnaire, the Hospital Anxiety and Depression Scale and the Life Orientation Test-Revised, two to six years after treatment. Results showed that 37% of the women reported severe fatigue. Women with severe fatigue scored lower on optimism than those without (15.5 vs 17.7, p < .0001). A logistic regression analysis with severe fatigue as the dependent variable showed that low level of optimism was significantly associated with severe fatigue, but the association was very low in comparison to emotional distress and chronic pain. The study's findings may be useful in directing breast cancer centers' effort to identify and provide comprehensive care for breast cancer survivors with severe fatigue.

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How common is fatigue in disease-free breast cancer survivors? A systematic review of the literature

Abstract: The authors conclude that there is good evidence of PTF occurring up to 5 years after completion of adjuvant therapy.

Cited by 164 publications

References 43 publications

Examination of Broad Symptom Improvement Resulting From Mindfulness-Based Stress Reduction in Breast Cancer Survivors: A Randomized Controlled Trial

Examination of Broad Symptom Improvement Resulting From Mindfulness-Based Stress Reduction in Breast Cancer Survivors: A Randomized Controlled Trial

Evaluation of screening instruments for depression and anxiety in breast cancer survivors

Is Dispositional Optimism Associated with Fatigue in Breast Cancer Survivors?

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