How cigarette smoke skews immune responses to promote infection, lung disease and cancer

Stämpfli, Martin R.; Anderson, Gary P.

doi:10.1038/nri2530

Cited by 580 publications

(533 citation statements)

References 108 publications

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“…We found that exomes marked by high levels of transversions had significantly lower levels of T cell infiltrate (P = 0.001), immune cell infiltrate (P = 0.001), and IFN-γ signaling (P = 4 × 10 -7 ) (Supplemental Figure 2). These data are consistent with prior evidence that tobacco smoking is associated with local immunosuppression and lower levels of cytotoxicity within the immune microenvironment (24). The exact mechanisms of smokingrelated immunosuppression are not well defined, but likely involve suppressive effects on NK cells, CD8 + T cells, and DCs (24).…”

Section: Resultssupporting

confidence: 80%

The head and neck cancer immune landscape and its immunotherapeutic implications

Mandal¹,

Şenbabaoğlu

Desrichard³

et al. 2016

JCI Insight

591

613

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Section: Resultssupporting

confidence: 80%

The head and neck cancer immune landscape and its immunotherapeutic implications

Mandal¹,

Şenbabaoğlu

Desrichard³

et al. 2016

JCI Insight

591

613

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“…To overcome some of these limitations, and to reduce possible data dispersion due to differences in genetic background and lifestyle, we investigated the effects of cigarette smoking on several immune parameters in healthy smoking-discordant twins: one a smoker and the other a non-smoker. The influence of smoke on leukocyte cell numbers and cell function has been demonstrated in several previous studies and our results are consistent with these findings [9,[32][33][34][35]. On the contrary, data concerning the influence of smoking on lymphocyte subpopulations are conflicting [35][36][37][38].…”

Section: Variablessupporting

confidence: 82%

Effects of cigarette smoking on circulating leukocytes and plasma cytokines in monozygotic twins

Andreoli¹,

Bassi²,

Gregg³

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Despite the well-documented role of cigarette smoke in the development of chronic obstructive pulmonary disease (COPD), lung cancer and cardiovascular disease, biomarkers for screening or monitoring disease progression and outcome remain elusive, particularly for COPD and lung cancer. Inflammatory cells and mediators are likely to be involved in the disease processes, but their importance is still poorly understood. The purpose of this study was to investigate early changes in immunological markers associated with smoking in healthy monozygotic twins without a detectable disease discordant for smoking, thereby minimising data variability due to genetic background. Methods: Twenty-two monozygotic twin pairs, aged 31.5 ± 6.3 years, entered the study. One of each twin pair was a smoker and the other a non-smoker. None of the subjects reported any diseases or clinically defined respiratory symptoms or airflow limitation. Each subject donated blood samples for determination of total leukocytes and subpopulations, lymphocyte subpopulation plus pro-inflammatory mediators (interleukin-8, tumour necrosis factor-α, soluble tumour necrosis factor-α receptors and C-reactive protein). Results: We observed a significant increase in the number of circulating leukocytes and neutrophils in smokers compared to non-smokers. Smokers also had significantly higher numbers of B cells and CD4 + T cells, plus an increased CD4/CD8 ratio. The numbers of NK cells were statistically significant lower in smokers compared to non-smokers.

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“…These factors are not sufficient, however, to explain the increased risk for invasive disease. Accordingly, it has been suggested that other mechanisms likely play a significant role in increasing the risk of IPD in smokers (17,20).…”

Section: Introductionmentioning

confidence: 99%

Neural Signaling in the Spleen Controls B-Cell Responses to Blood-Borne Antigen

Mina‐Osorio

Rosas-Ballina

Valdés-Ferrer

et al. 2012

Mol Med

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Entry of blood-borne pathogens into the spleen elicits a series of changes in cellular architecture that culminates in the systemic release of protective antibodies. Despite an abundance of work that has characterized these processes, the regulatory mechanisms that coordinate cell trafficking and antibody production are still poorly understood. Here, marginal zone (MZ) B cells responding to streptococcus in the blood were observed to migrate along splenic nerves, arriving at the red pulp venous sinuses where they become antibody-secreting cells. Electrical stimulation of the vagus nerve, which in turn regulates the splenic nerve, arrested B-cell migration and decreased antibody secretion. Thus, neural circuits regulate the first wave of antibody production following B-cell exposure to blood-borne antigen.

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How cigarette smoke skews immune responses to promote infection, lung disease and cancer

Cited by 580 publications

References 108 publications

The head and neck cancer immune landscape and its immunotherapeutic implications

The head and neck cancer immune landscape and its immunotherapeutic implications

Effects of cigarette smoking on circulating leukocytes and plasma cytokines in monozygotic twins

Neural Signaling in the Spleen Controls B-Cell Responses to Blood-Borne Antigen

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