How Cells of the Immune System Prepare the Endometrium for Implantation

Teles, Ana; Zenclussen, Ana Claudia

doi:10.1055/s-0034-1383735

Cited by 15 publications

(6 citation statements)

References 105 publications

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“…In the classic paradigm Th1/Th2, and their actualization Th1/Th2/Th17 Treg paradigm (Murtaugh et al 2009, Polese et al 2014, Saito et al 2010, mainly studied in mice and human, the expression of all the cytokines of the same type (Th1 or Th2) is similar along the gestation. This means that in those species, in early gestation there is a predominance of Th1 cytokines that are involved in the implantation window (Granot et al 2012, Teles & Zenclussen 2014. Then, through the gestation, the environment is fully of Th2/T17 cytokines, so that allows the gestation success (Saito et al 2010, Zenclussen 2013.…”

Section: Discussionmentioning

confidence: 99%

IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation

Vélez

Clauzure

Williamson³

et al. 2023

An. Acad. Bras. Ciênc.

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Concentration of interferon-gamma and interleukin-10 in maternal serum and in maternal and fetal porcine placental extracts from different gestation periods was determined. Crossbred pigs' placental samples of 17, 30, 60, 70, and 114 days gestation and non-pregnant uteri were used. Interferon-gamma concentration was increased at the placental interface at 17 days, in maternal and fetal placenta, and decreased significantly in the remaining gestation periods. Interferon-gamma showed a peak in serum at 60 days. Regarding interleukin-10, placental tissue concentrations were unaltered, there were no significant differences with non-gestating uteri samples. In serum interleukin-10 increased at 17, 60, and 114 days gestation. At 17 days there are uterus structural and molecular changes that allow the embryos implantation and placenta development. The presence of interferon-gamma found at this moment in the interface would favor that placental growth. Moreover, its significant increase in serum at 60 days, would generate a proinflammatory cytokine pattern that facility the placental remodeling characteristic of this moment of porcine gestation. On the other hand, a significant interleukin-10 increase in serum at 17, 60 and 114 days could indicate its immunoregulatory role at a systemic level during pig gestation.

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Section: Discussionmentioning

confidence: 99%

IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation

Vélez

Clauzure

Williamson³

et al. 2023

An. Acad. Bras. Ciênc.

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“…Ovulation is a series of events arising from changes within the dominant follicle, and angiogenesis is a crucial step in this process [104] involving angiogenic factors like bFGF, VEGF-A and histamine. Ovulation enables fertilization in the oviduct as shown in rats and mice [9,[101][102][103][105][106][107]. Uterine MCs express estrogen and progesterone surface receptors.…”

Section: Role In Reproductionmentioning

confidence: 99%

Section: Role In Reproductionmentioning

confidence: 99%

“…In the pregnant uterus, MC activation creates changes of the fetal maternal interface, tissue remodeling, spiral artery modifications, angiogenesis, and alterations in the muscular wall [94,101,106,108,109]. MC secretion is required for the development of the decidua as for vascularization, cell proliferation, and growth of the placenta [94,106]. In addition, MCs seem to control uterus contractions that are important for giving birth [9], while retaining their abilities of pathogen defense if the mother or fetus is in danger [8].…”

Section: Role In Reproductionmentioning

confidence: 99%

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On Mast Cells as Protectors of Life, Reproduction, and Progeny

Norrby

2024

Preprint

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The connective tissue mast cell (MC), a sentinel tissue-residing secretory immune cell, is preserved in all vertebrate classes since approximately 500 million years. No physiological role of the MCs has yet been established. Considering the power of natural selection of cells during evolution, it is likely that the MCs exert essential yet unidentified life-promoting actions. All vertebrates feature a circulatory system, and the MCs interact readily with the vasculature. It is notable that embryonic MC progenitors are generated from endothelial cells. The MC hosts many surface receptors enabling its activation by a vast variety of potentially harmful exogenous and endogenous molecules, and by reproductive hormones in the female sex organs. Activated MCs release a unique composition of pre-formed and newly synthesized bioactive molecules, like heparin, histamine, serotonin, proteolytic enzymes, cytokines, chemokines, and growth factors. MCs play important roles in immune responses, tissue remodeling, cell proliferation, angiogenesis, inflammation, wound healing, tissue homeostasis, health, and reproduction. As recently suggested, MCs enable perpetuation of the vertebrates because of key effects—spanning generations—in ovulation and pregnancy, as in life-preserving activities in inflammation and wound healing from birth till reproductive age, thus creating a permanent life-sustaining loop. Here, we present recent advances that further indicate that the MC is a specific life-supporting and progeny-safeguarding cell

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“…Once the apposition of the activated blastocyst is complete, the processes of adhesion and invasion must be initiated successively. A battery of physiological changes occurs in the cells and tissues of the uterus during early pregnancy, including morphological changes and the secretion of cytokines or proteins related to embryonic development and uterine receptivity [ 5 , 6 ]. Implantation failure is one of the main causes of infertility.…”

Section: Introductionmentioning

confidence: 99%

Expression and regulation of ATF6α in the mouse uterus during embryo implantation

Xiong

Lin

et al. 2016

Reprod Biol Endocrinol

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BackgroundATF6α, one of the sensor proteins in the stress signaling pathway of the endoplasmic reticulum, is located in the membrane of the endoplasmic reticulum. To date, the physiological function of ATF6α in the process of embryo implantation has not been reported.MethodsIn this study, the expression pattern of ATF6α in the mouse uterus during peri-implantation and the estrous cycle was detected by real-time PCR, western blot and immunohistochemistry.ResultsATF6α mRNA and protein levels were higher in the uterus near the implantation site on day 5 and were intensely expressed in the secondary decidual zone (SDZ) on days 7–8. In the uteri of pseudopregnant mice, ATF6α mRNA and protein levels were lower on day 5 than on other days. The activating blastocyst and artificial decidualization had an obvious effect of increasing the expression of ATF6α. In addition, the expression of ATF6α was affected by progesterone (P4) and estrogen (E2) in ovariectomized mice. This finding is further supported by evidence from mice during the estrous cycle.ConclusionsThus, we have concluded that ATF6α may play an important role during embryo implantation and decidualization.Electronic supplementary materialThe online version of this article (doi:10.1186/s12958-016-0199-0) contains supplementary material, which is available to authorized users.

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How Cells of the Immune System Prepare the Endometrium for Implantation

Cited by 15 publications

References 105 publications

IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation

IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation

On Mast Cells as Protectors of Life, Reproduction, and Progeny

Expression and regulation of ATF6α in the mouse uterus during embryo implantation

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